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A dual role for the anti-apoptotic Bcl-2 protein in cancer: mitochondria versus endoplasmic reticulum.
Akl H, Vervloessem T, Kiviluoto S, Bittremieux M, Parys JB, De Smedt H, Bultynck G. Akl H, et al. Biochim Biophys Acta. 2014 Oct;1843(10):2240-52. doi: 10.1016/j.bbamcr.2014.04.017. Epub 2014 Apr 21. Biochim Biophys Acta. 2014. PMID: 24768714 Free article. Review.
Interestingly, bio-informatic analysis of a database of primary CLL patient cells also revealed a transcriptional upregulation of IP3R2. ...Guest Editors: Geert Bultynck, Jacques Haiech, Claus W. Heizmann, Joachim Krebs, and Marc Moreau....
Interestingly, bio-informatic analysis of a database of primary CLL patient cells also revealed a transcriptional upregulation of IP3 …
Metabolic plasticity in CLL: adaptation to the hypoxic niche.
Koczula KM, Ludwig C, Hayden R, Cronin L, Pratt G, Parry H, Tennant D, Drayson M, Bunce CM, Khanim FL, Günther UL. Koczula KM, et al. Leukemia. 2016 Jan;30(1):65-73. doi: 10.1038/leu.2015.187. Epub 2015 Jul 23. Leukemia. 2016. PMID: 26202928 Free PMC article.
We have used a nuclear magnetic resonance based approach to monitor metabolism in living primary chronic lymphoid leukemia (CLL) cells and to interrogate their real-time metabolic responses to hypoxia. Our studies demonstrate considerable metabolic plasticity in CLL …
We have used a nuclear magnetic resonance based approach to monitor metabolism in living primary chronic lymphoid leukemia (CLL) cell …
Intracellular succinylation of 8-chloroadenosine and its effect on fumarate levels.
Dennison JB, Ayres ML, Kaluarachchi K, Plunkett W, Gandhi V. Dennison JB, et al. J Biol Chem. 2010 Mar 12;285(11):8022-30. doi: 10.1074/jbc.M109.085803. Epub 2010 Jan 11. J Biol Chem. 2010. PMID: 20064937 Free PMC article.
8-Chloroadenosine (8-Cl-Ado) is a ribosyl nucleoside analog currently in phase I testing for the treatment of chronic lymphocytic leukemia (CLL). 8-Cl-Ado activity is dependent on adenosine kinase and requires intracellular accumulation of 8-Cl-Ado as mono-, di-, and tri-p …
8-Chloroadenosine (8-Cl-Ado) is a ribosyl nucleoside analog currently in phase I testing for the treatment of chronic lymphocytic leukemia ( …