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Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.
Flynn BL, Gill GS, Grobelny DW, Chaplin JH, Paul D, Leske AF, Lavranos TC, Chalmers DK, Charman SA, Kostewicz E, Shackleford DM, Morizzi J, Hamel E, Jung MK, Kremmidiotis G. Flynn BL, et al. Among authors: kremmidiotis g. J Med Chem. 2011 Sep 8;54(17):6014-27. doi: 10.1021/jm200454y. Epub 2011 Aug 5. J Med Chem. 2011. PMID: 21774499 Free PMC article.
Clinical, pharmacodynamic, and pharmacokinetic evaluation of BNC105P: a phase I trial of a novel vascular disrupting agent and inhibitor of cancer cell proliferation.
Rischin D, Bibby DC, Chong G, Kremmidiotis G, Leske AF, Matthews CA, Wong SS, Rosen MA, Desai J. Rischin D, et al. Among authors: kremmidiotis g. Clin Cancer Res. 2011 Aug 1;17(15):5152-60. doi: 10.1158/1078-0432.CCR-11-0937. Epub 2011 Jun 20. Clin Cancer Res. 2011. PMID: 21690571 Clinical Trial.
A phase II clinical trial of the vascular disrupting agent BNC105P as second line chemotherapy for advanced Malignant Pleural Mesothelioma.
Nowak AK, Brown C, Millward MJ, Creaney J, Byrne MJ, Hughes B, Kremmidiotis G, Bibby DC, Leske AF, Mitchell PLR, Pavlakis N, Boyer M, Stockler MR. Nowak AK, et al. Among authors: kremmidiotis g. Lung Cancer. 2013 Sep;81(3):422-427. doi: 10.1016/j.lungcan.2013.05.006. Epub 2013 Jun 17. Lung Cancer. 2013. PMID: 23787063 Clinical Trial.
Phase I study of BNC105P, carboplatin and gemcitabine in partially platinum-sensitive ovarian cancer patients in first or second relapse (ANZGOG-1103).
Lindemann K, Beale PJ, Rossi E, Goh JC, Vaughan MM, Tenney ME, Martyn JK, Sommeijer D, Iglesias JL, Kremmidiotis G, Simpson J, Doolin E, Lavranos TC, Leske A, Veillard AS, Espinoza D, Stockler MR, Rischin D; For ANZGOG and HCRN Collaborative Groups. Lindemann K, et al. Among authors: kremmidiotis g. Cancer Chemother Pharmacol. 2019 Jan;83(1):97-105. doi: 10.1007/s00280-018-3706-5. Epub 2018 Oct 27. Cancer Chemother Pharmacol. 2019. PMID: 30368585 Clinical Trial.
A Phase I/II Trial of BNC105P with Everolimus in Metastatic Renal Cell Carcinoma.
Pal S, Azad A, Bhatia S, Drabkin H, Costello B, Sarantopoulos J, Kanesvaran R, Lauer R, Starodub A, Hauke R, Sweeney CJ, Hahn NM, Sonpavde G, Richey S, Breen T, Kremmidiotis G, Leske A, Doolin E, Bibby DC, Simpson J, Iglesias J, Hutson T. Pal S, et al. Among authors: kremmidiotis g. Clin Cancer Res. 2015 Aug 1;21(15):3420-7. doi: 10.1158/1078-0432.CCR-14-3370. Epub 2015 Mar 18. Clin Cancer Res. 2015. PMID: 25788492 Free PMC article. Clinical Trial.
A vascular cell-restricted RhoGAP, p73RhoGAP, is a key regulator of angiogenesis.
Su ZJ, Hahn CN, Goodall GJ, Reck NM, Leske AF, Davy A, Kremmidiotis G, Vadas MA, Gamble JR. Su ZJ, et al. Among authors: kremmidiotis g. Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12212-7. doi: 10.1073/pnas.0404631101. Epub 2004 Aug 9. Proc Natl Acad Sci U S A. 2004. PMID: 15302923 Free PMC article.
Aberrant CBFA2T3B gene promoter methylation in breast tumors.
Bais AJ, Gardner AE, McKenzie OL, Callen DF, Sutherland GR, Kremmidiotis G. Bais AJ, et al. Among authors: kremmidiotis g. Mol Cancer. 2004 Aug 10;3:22. doi: 10.1186/1476-4598-3-22. Mol Cancer. 2004. PMID: 15301688 Free PMC article.
28 results