Krojer T - Search Results

1

Structural basis for the regulated protease and chaperone function of DegP.

Krojer T, Sawa J, Schäfer E, Saibil HR, Ehrmann M, Clausen T. Krojer T, et al. Nature. 2008 Jun 12;453(7197):885-90. doi: 10.1038/nature07004. Epub 2008 May 21. Nature. 2008. PMID: 18496527

2

Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine.

Krojer T, Garrido-Franco M, Huber R, Ehrmann M, Clausen T. Krojer T, et al. Nature. 2002 Mar 28;416(6879):455-9. doi: 10.1038/416455a. Nature. 2002. PMID: 11919638

3

Regulation of the sigmaE stress response by DegS: how the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stress.

Hasselblatt H, Kurzbauer R, Wilken C, Krojer T, Sawa J, Kurt J, Kirk R, Hasenbein S, Ehrmann M, Clausen T. Hasselblatt H, et al. Among authors: krojer t. Genes Dev. 2007 Oct 15;21(20):2659-70. doi: 10.1101/gad.445307. Genes Dev. 2007. PMID: 17938245 Free PMC article.

4

Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins.

Krojer T, Pangerl K, Kurt J, Sawa J, Stingl C, Mechtler K, Huber R, Ehrmann M, Clausen T. Krojer T, et al. Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7702-7. doi: 10.1073/pnas.0803392105. Epub 2008 May 27. Proc Natl Acad Sci U S A. 2008. PMID: 18505836 Free PMC article.

5

HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues.

Krojer T, Sawa J, Huber R, Clausen T. Krojer T, et al. Nat Struct Mol Biol. 2010 Jul;17(7):844-52. doi: 10.1038/nsmb.1840. Epub 2010 Jun 27. Nat Struct Mol Biol. 2010. PMID: 20581825

6

Molecular adaptation of the DegQ protease to exert protein quality control in the bacterial cell envelope.

Sawa J, Malet H, Krojer T, Canellas F, Ehrmann M, Clausen T. Sawa J, et al. Among authors: krojer t. J Biol Chem. 2011 Sep 2;286(35):30680-30690. doi: 10.1074/jbc.M111.243832. Epub 2011 Jun 17. J Biol Chem. 2011. PMID: 21685389 Free PMC article.

7

Selectivity profiling of DegP substrates and inhibitors.

Hauske P, Meltzer M, Ottmann C, Krojer T, Clausen T, Ehrmann M, Kaiser M. Hauske P, et al. Among authors: krojer t. Bioorg Med Chem. 2009 Apr 1;17(7):2920-4. doi: 10.1016/j.bmc.2009.01.073. Epub 2009 Feb 5. Bioorg Med Chem. 2009. PMID: 19233659

8

Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli.

Meltzer M, Hasenbein S, Mamant N, Merdanovic M, Poepsel S, Hauske P, Kaiser M, Huber R, Krojer T, Clausen T, Ehrmann M. Meltzer M, et al. Among authors: krojer t. Res Microbiol. 2009 Nov;160(9):660-6. doi: 10.1016/j.resmic.2009.07.012. Epub 2009 Aug 18. Res Microbiol. 2009. PMID: 19695325 Free article. Review.

9

Substrate-induced remodeling of the active site regulates human HTRA1 activity.

Truebestein L, Tennstaedt A, Mönig T, Krojer T, Canellas F, Kaiser M, Clausen T, Ehrmann M. Truebestein L, et al. Among authors: krojer t. Nat Struct Mol Biol. 2011 Mar;18(3):386-8. doi: 10.1038/nsmb.2013. Epub 2011 Feb 6. Nat Struct Mol Biol. 2011. PMID: 21297635

10

Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality control.

Meltzer M, Hasenbein S, Hauske P, Kucz N, Merdanovic M, Grau S, Beil A, Jones D, Krojer T, Clausen T, Ehrmann M, Kaiser M. Meltzer M, et al. Among authors: krojer t. Angew Chem Int Ed Engl. 2008;47(7):1332-4. doi: 10.1002/anie.200703273. Angew Chem Int Ed Engl. 2008. PMID: 18175296 No abstract available.

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