Kuhn B - Search Results

1

A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature.

Kemble AM, Hornsperger B, Ruf I, Richter H, Benz J, Kuhn B, Heer D, Wittwer M, Engelhardt B, Grether U, Collin L. Kemble AM, et al. Among authors: kuhn b. PLoS One. 2022 Sep 9;17(9):e0268590. doi: 10.1371/journal.pone.0268590. eCollection 2022. PLoS One. 2022. PMID: 36084029 Free PMC article.

2

A novel partial agonist of peroxisome proliferator-activated receptor-gamma (PPARgamma) recruits PPARgamma-coactivator-1alpha, prevents triglyceride accumulation, and potentiates insulin signaling in vitro.

Burgermeister E, Schnoebelen A, Flament A, Benz J, Stihle M, Gsell B, Rufer A, Ruf A, Kuhn B, Märki HP, Mizrahi J, Sebokova E, Niesor E, Meyer M. Burgermeister E, et al. Among authors: kuhn b. Mol Endocrinol. 2006 Apr;20(4):809-30. doi: 10.1210/me.2005-0171. Epub 2005 Dec 22. Mol Endocrinol. 2006. PMID: 16373399

3

Structure-based design of indole propionic acids as novel PPARalpha/gamma co-agonists.

Kuhn B, Hilpert H, Benz J, Binggeli A, Grether U, Humm R, Märki HP, Meyer M, Mohr P. Kuhn B, et al. Bioorg Med Chem Lett. 2006 Aug 1;16(15):4016-20. doi: 10.1016/j.bmcl.2006.05.007. Epub 2006 Jun 5. Bioorg Med Chem Lett. 2006. PMID: 16737814

4

Synthesis and evaluation of anilinohexafluoroisopropanols as activators/modulators of LXRalpha and beta.

Panday N, Benz J, Blum-Kaelin D, Bourgeaux V, Dehmlow H, Hartman P, Kuhn B, Ratni H, Warot X, Wright MB. Panday N, et al. Among authors: kuhn b. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5231-7. doi: 10.1016/j.bmcl.2006.06.081. Epub 2006 Jul 31. Bioorg Med Chem Lett. 2006. PMID: 16876993

5

Allosteric FBPase inhibitors gain 10(5) times in potency when simultaneously binding two neighboring AMP sites.

Hebeisen P, Kuhn B, Kohler P, Gubler M, Huber W, Kitas E, Schott B, Benz J, Joseph C, Ruf A. Hebeisen P, et al. Among authors: kuhn b. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4708-12. doi: 10.1016/j.bmcl.2008.06.103. Epub 2008 Jul 5. Bioorg Med Chem Lett. 2008. PMID: 18650089

6

Design of novel aminopyrrolidine factor Xa inhibitors from a screening hit.

Zbinden KG, Anselm L, Banner DW, Benz J, Blasco F, Décoret G, Himber J, Kuhn B, Panday N, Ricklin F, Risch P, Schlatter D, Stahl M, Thomi S, Unger R, Haap W. Zbinden KG, et al. Among authors: kuhn b. Eur J Med Chem. 2009 Jul;44(7):2787-95. doi: 10.1016/j.ejmech.2008.12.025. Epub 2009 Jan 3. Eur J Med Chem. 2009. PMID: 19200624

7

Design and biological evaluation of novel, balanced dual PPARalpha/gamma agonists.

Grether U, Bénardeau A, Benz J, Binggeli A, Blum D, Hilpert H, Kuhn B, Märki HP, Meyer M, Mohr P, Püntener K, Raab S, Ruf A, Schlatter D. Grether U, et al. Among authors: kuhn b. ChemMedChem. 2009 Jun;4(6):951-6. doi: 10.1002/cmdc.200800425. ChemMedChem. 2009. PMID: 19326383

8

Identification of an N-oxide pyridine GW4064 analog as a potent FXR agonist.

Feng S, Yang M, Zhang Z, Wang Z, Hong D, Richter H, Benson GM, Bleicher K, Grether U, Martin RE, Plancher JM, Kuhn B, Rudolph MG, Chen L. Feng S, et al. Among authors: kuhn b. Bioorg Med Chem Lett. 2009 May 1;19(9):2595-8. doi: 10.1016/j.bmcl.2009.03.008. Epub 2009 Mar 9. Bioorg Med Chem Lett. 2009. PMID: 19328688

9

Aleglitazar, a new, potent, and balanced dual PPARalpha/gamma agonist for the treatment of type II diabetes.

Bénardeau A, Benz J, Binggeli A, Blum D, Boehringer M, Grether U, Hilpert H, Kuhn B, Märki HP, Meyer M, Püntener K, Raab S, Ruf A, Schlatter D, Mohr P. Bénardeau A, et al. Among authors: kuhn b. Bioorg Med Chem Lett. 2009 May 1;19(9):2468-73. doi: 10.1016/j.bmcl.2009.03.036. Epub 2009 Mar 14. Bioorg Med Chem Lett. 2009. PMID: 19349176

10

Sulfonylureido thiazoles as fructose-1,6-bisphosphatase inhibitors for the treatment of type-2 diabetes.

Kitas E, Mohr P, Kuhn B, Hebeisen P, Wessel HP, Haap W, Ruf A, Benz J, Joseph C, Huber W, Sanchez RA, Paehler A, Benardeau A, Gubler M, Schott B, Tozzo E. Kitas E, et al. Among authors: kuhn b. Bioorg Med Chem Lett. 2010 Jan 15;20(2):594-9. doi: 10.1016/j.bmcl.2009.11.093. Epub 2009 Nov 22. Bioorg Med Chem Lett. 2010. PMID: 19969452

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