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HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity.
Kurita M, Holloway T, García-Bea A, Kozlenkov A, Friedman AK, Moreno JL, Heshmati M, Golden SA, Kennedy PJ, Takahashi N, Dietz DM, Mocci G, Gabilondo AM, Hanks J, Umali A, Callado LF, Gallitano AL, Neve RL, Shen L, Buxbaum JD, Han MH, Nestler EJ, Meana JJ, Russo SJ, González-Maeso J. Kurita M, et al. Nat Neurosci. 2012 Sep;15(9):1245-54. doi: 10.1038/nn.3181. Epub 2012 Aug 5. Nat Neurosci. 2012. PMID: 22864611 Free PMC article.
Antipsychotic-induced Hdac2 transcription via NF-κB leads to synaptic and cognitive side effects.
Ibi D, de la Fuente Revenga M, Kezunovic N, Muguruza C, Saunders JM, Gaitonde SA, Moreno JL, Ijaz MK, Santosh V, Kozlenkov A, Holloway T, Seto J, García-Bea A, Kurita M, Mosley GE, Jiang Y, Christoffel DJ, Callado LF, Russo SJ, Dracheva S, López-Giménez JF, Ge Y, Escalante CR, Meana JJ, Akbarian S, Huntley GW, González-Maeso J. Ibi D, et al. Among authors: kurita m. Nat Neurosci. 2017 Sep;20(9):1247-1259. doi: 10.1038/nn.4616. Epub 2017 Aug 7. Nat Neurosci. 2017. PMID: 28783139 Free PMC article.
Chronic clozapine treatment restrains via HDAC2 the performance of mGlu2 receptor agonism in a rodent model of antipsychotic activity.
de la Fuente Revenga M, Ibi D, Cuddy T, Toneatti R, Kurita M, Ijaz MK, Miles MF, Wolstenholme JT, González-Maeso J. de la Fuente Revenga M, et al. Among authors: kurita m. Neuropsychopharmacology. 2019 Jan;44(2):443-454. doi: 10.1038/s41386-018-0143-4. Epub 2018 Jul 7. Neuropsychopharmacology. 2019. PMID: 30038413 Free PMC article.
HDAC2 as a new target to improve schizophrenia treatment.
Kurita M, Holloway T, González-Maeso J. Kurita M, et al. Expert Rev Neurother. 2013 Jan;13(1):1-3. doi: 10.1586/ern.12.141. Expert Rev Neurother. 2013. PMID: 23253383 Free PMC article. No abstract available.
353 results