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Nootropic drug modulation of neuronal nicotinic acetylcholine receptors in rat cortical neurons.
Zhao X, Kuryatov A, Lindstrom JM, Yeh JZ, Narahashi T. Zhao X, et al. Among authors: kuryatov a. Mol Pharmacol. 2001 Apr;59(4):674-83. doi: 10.1124/mol.59.4.674. Mol Pharmacol. 2001. PMID: 11259610
Nefiracetam (DM-9384) is a new pyrrolidone nootropic drug being developed for the treatment of Alzheimer's type and poststroke vascular-type dementia. ...Nefiracetam at very high concentrations (approximately 10 microM) also potentiated alpha 4 beta 2-type currents but to …
Nefiracetam (DM-9384) is a new pyrrolidone nootropic drug being developed for the treatment of Alzheimer's type and poststroke vascul …
Mutations of cytosolic loop residues impair assembly and maturation of alpha7 nicotinic acetylcholine receptors.
Mukherjee J, Kuryatov A, Moss SJ, Lindstrom JM, Anand R. Mukherjee J, et al. Among authors: kuryatov a. J Neurochem. 2009 Sep;110(6):1885-94. doi: 10.1111/j.1471-4159.2009.06285.x. Epub 2009 Jul 17. J Neurochem. 2009. PMID: 19627445 Free PMC article.
Transfection of alpha7 AChRs in SH-SY5Y cells, which endogenously express the alpha7 AChR, results in a much larger fraction of subunits assembled into mature AChRs. ...
Transfection of alpha7 AChRs in SH-SY5Y cells, which endogenously express the alpha7 AChR, results in a much larger fraction of subun …
Acetylcholine receptor (AChR) α5 subunit variant associated with risk for nicotine dependence and lung cancer reduces (α4β2)₂α5 AChR function.
Kuryatov A, Berrettini W, Lindstrom J. Kuryatov A, et al. Mol Pharmacol. 2011 Jan;79(1):119-25. doi: 10.1124/mol.110.066357. Epub 2010 Sep 29. Mol Pharmacol. 2011. PMID: 20881005 Free PMC article.
Genomic studies have identified a D398N variation in the α5 subunit of nicotinic acetylcholine receptors (AChRs) that increases risk of nicotine dependence and lung cancer. ...The low sensitivity to activation and desensitization of (α3β4)₂α5 AChRs by nicotine results in …
Genomic studies have identified a D398N variation in the α5 subunit of nicotinic acetylcholine receptors (AChRs) that increases risk …
Unorthodox Acetylcholine Binding Sites Formed by α5 and β3 Accessory Subunits in α4β2* Nicotinic Acetylcholine Receptors.
Jain A, Kuryatov A, Wang J, Kamenecka TM, Lindstrom J. Jain A, et al. Among authors: kuryatov a. J Biol Chem. 2016 Nov 4;291(45):23452-23463. doi: 10.1074/jbc.M116.749150. Epub 2016 Sep 19. J Biol Chem. 2016. PMID: 27645992 Free PMC article.
A Novel α2/α4 Subtype-selective Positive Allosteric Modulator of Nicotinic Acetylcholine Receptors Acting from the C-tail of an α Subunit.
Wang J, Kuryatov A, Jin Z, Norleans J, Kamenecka TM, Kenny PJ, Lindstrom J. Wang J, et al. Among authors: kuryatov a. J Biol Chem. 2015 Nov 27;290(48):28834-46. doi: 10.1074/jbc.M115.676551. Epub 2015 Oct 2. J Biol Chem. 2015. PMID: 26432642 Free PMC article.
An Accessory Agonist Binding Site Promotes Activation of α4β2* Nicotinic Acetylcholine Receptors.
Wang J, Kuryatov A, Sriram A, Jin Z, Kamenecka TM, Kenny PJ, Lindstrom J. Wang J, et al. Among authors: kuryatov a. J Biol Chem. 2015 May 29;290(22):13907-18. doi: 10.1074/jbc.M115.646786. Epub 2015 Apr 13. J Biol Chem. 2015. PMID: 25869137 Free PMC article.
Expression of cloned α6* nicotinic acetylcholine receptors.
Wang J, Kuryatov A, Lindstrom J. Wang J, et al. Among authors: kuryatov a. Neuropharmacology. 2015 Sep;96(Pt B):194-204. doi: 10.1016/j.neuropharm.2014.10.009. Epub 2014 Oct 16. Neuropharmacology. 2015. PMID: 25446669 Review.
Beta3 subunits promote expression and nicotine-induced up-regulation of human nicotinic alpha6* nicotinic acetylcholine receptors expressed in transfected cell lines.
Tumkosit P, Kuryatov A, Luo J, Lindstrom J. Tumkosit P, et al. Among authors: kuryatov a. Mol Pharmacol. 2006 Oct;70(4):1358-68. doi: 10.1124/mol.106.027326. Epub 2006 Jul 11. Mol Pharmacol. 2006. PMID: 16835356
The increased sensitivity to nicotine-induced up-regulation was due not to a beta3-induced increase in affinity for nicotine but probably to a direct effect on assembly of AChR subunits. HEK cells express only a small amount of mature alpha6beta2 AChRs, but m …
The increased sensitivity to nicotine-induced up-regulation was due not to a beta3-induced increase in affinity for nicotine but prob …
Analogs of alpha-conotoxin MII are selective for alpha6-containing nicotinic acetylcholine receptors.
McIntosh JM, Azam L, Staheli S, Dowell C, Lindstrom JM, Kuryatov A, Garrett JE, Marks MJ, Whiteaker P. McIntosh JM, et al. Among authors: kuryatov a. Mol Pharmacol. 2004 Apr;65(4):944-52. doi: 10.1124/mol.65.4.944. Mol Pharmacol. 2004. PMID: 15044624
Alpha-conotoxin MII, a selective ligand that discriminates among a variety of nAChR subtypes, fails to discriminate well between some subtypes containing the closely related alpha3 and alpha6 subunits. ...The peptide had a 590-fold lower IC(50) for alpha6/alp …
Alpha-conotoxin MII, a selective ligand that discriminates among a variety of nAChR subtypes, fails to discriminate well betwe …
Human alpha4beta2 acetylcholine receptors formed from linked subunits.
Zhou Y, Nelson ME, Kuryatov A, Choi C, Cooper J, Lindstrom J. Zhou Y, et al. Among authors: kuryatov a. J Neurosci. 2003 Oct 8;23(27):9004-15. doi: 10.1523/JNEUROSCI.23-27-09004.2003. J Neurosci. 2003. PMID: 14534234 Free PMC article.
We prepared concatamers of alpha4 and beta2 subunits for human nicotinic acetylcholine receptors (AChRs), in which the C terminus of alpha4 was linked to the N terminus of beta2, or vice versa, via a tripeptide sequence repeated 6 or 12 times, and expressed them in Xenopus …
We prepared concatamers of alpha4 and beta2 subunits for human nicotinic acetylcholine receptors (AChRs), in which the C terminus of alpha4 …
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