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Synthesis of C3/C1-Substituted Tetrahydroisoquinolines.
Mihoubi M, Micale N, Scala A, Jarraya RM, Bouaziz A, Schirmeister T, Risitano F, Piperno A, Grassi G. Mihoubi M, et al. Molecules. 2015 Aug 14;20(8):14902-14. doi: 10.3390/molecules200814902. Molecules. 2015. PMID: 26287146 Free PMC article.
A broad biological screening of the natural alkaloid N-methylisosalsoline (2) extracted from Hammada scoparia leaves against a panel of human and parasitic proteases revealed an interesting activity profile of 2 towards human 20S proteasome. This outcome suggests that the …
A broad biological screening of the natural alkaloid N-methylisosalsoline (2) extracted from Hammada scoparia leaves against a panel of huma …
Acylated protopanaxadiol-type ginsenosides from the root of Panax ginseng.
Zhu GY, Li YW, Hau DK, Jiang ZH, Yu ZL, Fong WF. Zhu GY, et al. Chem Biodivers. 2011 Oct;8(10):1853-63. doi: 10.1002/cbdv.201000196. Chem Biodivers. 2011. PMID: 22006713
The structures of the new compounds were determined by spectroscopic methods, including 1D- and 2D-NMR, HR-MS, and chemical transformation as (20S)- 3-O-{beta-D-6-O-[(E)-but-2-enoyl]glucopyranosyl-(12)-beta-D-glucopyranosyl}-20-O-[beta-D-xylopyranosyl-(14)-alpha-L-a …
The structures of the new compounds were determined by spectroscopic methods, including 1D- and 2D-NMR, HR-MS, and chemical transformation a …
Enzymatic Synthesis of Unnatural Ginsenosides Using a Promiscuous UDP-Glucosyltransferase from Bacillus subtilis.
Zhang TT, Gong T, Hu ZF, Gu AD, Yang JL, Zhu P. Zhang TT, et al. Molecules. 2018 Oct 28;23(11):2797. doi: 10.3390/molecules23112797. Molecules. 2018. PMID: 30373312 Free PMC article.
The results showed that UGT109A1 could transfer a glucosyl moiety to C3-OH of ginsenosides Re and R1, and C3-OH and C12-OH of ginsenosides Rf and Rh1, respectively, to produce unnatural ginsenosides 3,20-di-O-beta-d-glucopyranosyl-6-O-[alpha-l-rhamnopyrano-(1 …
The results showed that UGT109A1 could transfer a glucosyl moiety to C3-OH of ginsenosides Re and R1, and C3-OH and C12-OH of …
Production of a bioactive unnatural ginsenoside by metabolically engineered yeasts based on a new UDP-glycosyltransferase from Bacillus subtilis.
Liang H, Hu Z, Zhang T, Gong T, Chen J, Zhu P, Li Y, Yang J. Liang H, et al. Metab Eng. 2017 Nov;44:60-69. doi: 10.1016/j.ymben.2017.07.008. Epub 2017 Aug 2. Metab Eng. 2017. PMID: 28778764 Free article.
In our study, a new UDP-glycosyltransferase UGT109A1 was identified from Bacillus subtilis. This enzyme transferred a glucose moiety to C3-OH and C20-OH of dammarenediol-II (DM), C3-OH and C12-OH of PPD and PPT respectively to produce the unnatural ginsenosides 3bet …
In our study, a new UDP-glycosyltransferase UGT109A1 was identified from Bacillus subtilis. This enzyme transferred a glucose moiety to C
Characterization and electronic structures of five members of the electron transfer series [Re(benzene-1,2-dithiolato)3](z) (z = 1+, 0, 1-, 2-, 3-): a spectroscopic and density functional theoretical study.
Sproules S, Benedito FL, Bill E, Weyhermüller T, DeBeer George S, Wieghardt K. Sproules S, et al. Inorg Chem. 2009 Dec 7;48(23):10926-41. doi: 10.1021/ic9010532. Inorg Chem. 2009. PMID: 19831363
The electrochemistry establishes that the complexes are members of electron transfer series involving a monocation [Re(V)(L(*))(2)(L)](+) (S = 0(?)), a neutral [Re(V)(L(*))(L)(2)](0) (S = 1/2), a monoanion [Re(V)(L)(3)](1-) (S = 0), a dianion [R …
The electrochemistry establishes that the complexes are members of electron transfer series involving a monocation [Re(V)(L(*))(2)( …
New dammarane-type saponins from the galls of Sapindus mukorossi.
Kuo YH, Huang HC, Yang Kuo LM, Hsu YW, Lee KH, Chang FR, Wu YC. Kuo YH, et al. J Agric Food Chem. 2005 Jun 15;53(12):4722-7. doi: 10.1021/jf047963s. J Agric Food Chem. 2005. PMID: 15941306
Five new dammarane-type saponins, 3beta,7beta,20(S),22-tetrahydroxydammar-24-ene-3-O-alpha-l-rhamnopyranosyl-(1-->2)-beta-D-glucopyranoside, 3beta,7beta,20(S),22,23-pentahydroxydammar-24-ene-3-O-alpha-l-rhamnopyranosyl-(1-->2)-beta-D-glucopyranoside, 3beta,7be …
Five new dammarane-type saponins, 3beta,7beta,20(S),22-tetrahydroxydammar-24-ene-3-O-alpha-l-rhamnopyranosyl-(1-->2)-beta-D-glucop …
Rare ginsenoside Ia synthesized from F1 by cloning and overexpression of the UDP-glycosyltransferase gene from Bacillus subtilis: synthesis, characterization, and in vitro melanogenesis inhibition activity in BL6B16 cells.
Wang DD, Jin Y, Wang C, Kim YJ, Perez ZEJ, Baek NI, Mathiyalagan R, Markus J, Yang DC. Wang DD, et al. J Ginseng Res. 2018 Jan;42(1):42-49. doi: 10.1016/j.jgr.2016.12.009. Epub 2016 Dec 24. J Ginseng Res. 2018. PMID: 29348721 Free PMC article.
The new product was characterized by NMR techniques and evaluated by MTT, melanin count, and tyrosinase inhibition assay. RESULTS: The new derivative was identified as (20S)-3beta,6alpha,12beta,20-tetrahydroxydammar-24-ene-20-O-beta-D-glucopyranosyl-3-O-beta-D-glucopyranos …
The new product was characterized by NMR techniques and evaluated by MTT, melanin count, and tyrosinase inhibition assay. RESULTS: The new d …
Rheological properties of erythrocytes in patients suffering from erysipelas. Examination with LORCA device.
Biesiada G, Krzemień J, Czepiel J, Teległów A, Dabrowski Z, Spodaryk K, Mach T. Biesiada G, et al. Clin Hemorheol Microcirc. 2006;34(3):383-90. Clin Hemorheol Microcirc. 2006. PMID: 16614462
Basic peripheral blood parameters studied in patients with erysipelas did not differ significantly from the control group except for WBC, fibrinogen (C - 3.8 g/l, P - 7.8 g/l), and ESR (C - 6.1 mm/h, P - 45.4 mm/h) which were significantly higher....
Basic peripheral blood parameters studied in patients with erysipelas did not differ significantly from the control group except for WBC, fi …
Pregnane glycosides, gymnepregosides G-Q from the roots of Gymnema alternifolium.
Yoshikawa K, Matsuchika K, Takahashi K, Tanaka M, Arihara S, Chang HC, Wang JD. Yoshikawa K, et al. Chem Pharm Bull (Tokyo). 1999 Jun;47(6):798-804. doi: 10.1248/cpb.47.798. Chem Pharm Bull (Tokyo). 1999. PMID: 10399837
The structural elucidation of eleven new related polyoxypregnane glycosides, gymnepregosides G (1), H (2), I (3), J (4), K (5), L (6), M (7), N (8), O (9), P (10) and Q (11), from the roots of Gymnema alternifolium (Asclepiadaceae) was achieved by a detailed study of 1H- a …
The structural elucidation of eleven new related polyoxypregnane glycosides, gymnepregosides G (1), H (2), I (3), J (4), K (5), L (6) …