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ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo.
Burgess BL, Parkinson PF, Racke MM, Hirsch-Reinshagen V, Fan J, Wong C, Stukas S, Theroux L, Chan JY, Donkin J, Wilkinson A, Balik D, Christie B, Poirier J, Lütjohann D, Demattos RB, Wellington CL. Burgess BL, et al. Among authors: lutjohann d. J Lipid Res. 2008 Jun;49(6):1254-67. doi: 10.1194/jlr.M700481-JLR200. Epub 2008 Feb 26. J Lipid Res. 2008. PMID: 18314463 Free article.
Overexpression of human ABCG1 does not affect atherosclerosis in fat-fed ApoE-deficient mice.
Burgess B, Naus K, Chan J, Hirsch-Reinshagen V, Tansley G, Matzke L, Chan B, Wilkinson A, Fan J, Donkin J, Balik D, Tanaka T, Ou G, Dyer R, Innis S, McManus B, Lütjohann D, Wellington C. Burgess B, et al. Among authors: lutjohann d. Arterioscler Thromb Vasc Biol. 2008 Oct;28(10):1731-7. doi: 10.1161/ATVBAHA.108.168542. Epub 2008 Jul 3. Arterioscler Thromb Vasc Biol. 2008. PMID: 18599800
LCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteins.
Hirsch-Reinshagen V, Donkin J, Stukas S, Chan J, Wilkinson A, Fan J, Parks JS, Kuivenhoven JA, Lütjohann D, Pritchard H, Wellington CL. Hirsch-Reinshagen V, et al. Among authors: lutjohann d. J Lipid Res. 2009 May;50(5):885-93. doi: 10.1194/jlr.M800584-JLR200. Epub 2008 Dec 8. J Lipid Res. 2009. PMID: 19065001 Free PMC article.
Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function.
Karasinska JM, Rinninger F, Lütjohann D, Ruddle P, Franciosi S, Kruit JK, Singaraja RR, Hirsch-Reinshagen V, Fan J, Brunham LR, Bissada N, Ramakrishnan R, Wellington CL, Parks JS, Hayden MR. Karasinska JM, et al. Among authors: lutjohann d. J Neurosci. 2009 Mar 18;29(11):3579-89. doi: 10.1523/JNEUROSCI.4741-08.2009. J Neurosci. 2009. PMID: 19295162 Free PMC article.
Loss of both ABCA1 and ABCG1 results in increased disturbances in islet sterol homeostasis, inflammation, and impaired β-cell function.
Kruit JK, Wijesekara N, Westwell-Roper C, Vanmierlo T, de Haan W, Bhattacharjee A, Tang R, Wellington CL, LütJohann D, Johnson JD, Brunham LR, Verchere CB, Hayden MR. Kruit JK, et al. Among authors: lutjohann d. Diabetes. 2012 Mar;61(3):659-64. doi: 10.2337/db11-1341. Epub 2012 Feb 7. Diabetes. 2012. PMID: 22315310 Free PMC article.
ABCA1 influences neuroinflammation and neuronal death.
Karasinska JM, de Haan W, Franciosi S, Ruddle P, Fan J, Kruit JK, Stukas S, Lütjohann D, Gutmann DH, Wellington CL, Hayden MR. Karasinska JM, et al. Among authors: lutjohann d. Neurobiol Dis. 2013 Jun;54:445-55. doi: 10.1016/j.nbd.2013.01.018. Epub 2013 Jan 30. Neurobiol Dis. 2013. PMID: 23376685
Selective sterol accumulation in ABCG5/ABCG8-deficient mice.
Yu L, von Bergmann K, Lutjohann D, Hobbs HH, Cohen JC. Yu L, et al. Among authors: lutjohann d. J Lipid Res. 2004 Feb;45(2):301-7. doi: 10.1194/jlr.M300377-JLR200. Epub 2003 Dec 1. J Lipid Res. 2004. PMID: 14657202 Free article.
410 results