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2014 1
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LARP4A and LARP4B in cancer: The new kids on the block.
Coleman JC, Hallett SR, Grigoriadis AE, Conte MR. Coleman JC, et al. Int J Biochem Cell Biol. 2023 Aug;161:106441. doi: 10.1016/j.biocel.2023.106441. Epub 2023 Jun 23. Int J Biochem Cell Biol. 2023. PMID: 37356415 Free article.
Recent developments have mounted a stunning body of evidence underlying the importance of RNA binding proteins (RBPs) in cancer research. In this minireview we focus on LARP4A and LARP4B, two paralogs belonging to the superfamily of La-related proteins, and provide …
Recent developments have mounted a stunning body of evidence underlying the importance of RNA binding proteins (RBPs) in cancer resea …
Expression of La Ribonucleoprotein Domain Family Member 4B (LARP4B) in Liver Cancer and Their Clinical and Prognostic Significance.
Li Y, Jiao Y, Li Y, Liu Y. Li Y, et al. Dis Markers. 2019 Oct 22;2019:1569049. doi: 10.1155/2019/1569049. eCollection 2019. Dis Markers. 2019. PMID: 31772683 Free PMC article.
We aimed to explore the role of LARP4B in the diagnosis and prognosis of liver cancer. METHODS: The Cancer Genome Atlas (TCGA) database was searched to detect LARP4B gene expression in liver cancer. ...Additionally, we carried out gene set enric …
We aimed to explore the role of LARP4B in the diagnosis and prognosis of liver cancer. METHODS: The Cancer Genome Atlas …
Genome-wide exploration of genetic interactions for bladder cancer risk.
Yu EY, Tang QY, Chen YT, Zhang YX, Dai YN, Wu YX, Li WC, Mehrkanoon S, Wang SZ, Zeegers MP, Wesselius A. Yu EY, et al. Int J Cancer. 2024 Jan 1;154(1):81-93. doi: 10.1002/ijc.34690. Epub 2023 Aug 28. Int J Cancer. 2024. PMID: 37638657
Although GWASs have been conducted to investigate genetic variation of bladder tumorigenesis, little is known about genetic interactions that may influence bladder cancer (BC) risk. By leveraging large-scale participants from UK Biobank, we established a discovery database …
Although GWASs have been conducted to investigate genetic variation of bladder tumorigenesis, little is known about genetic interactions tha …
The La-Related Proteins, a Family with Connections to Cancer.
Stavraka C, Blagden S. Stavraka C, et al. Biomolecules. 2015 Oct 16;5(4):2701-22. doi: 10.3390/biom5042701. Biomolecules. 2015. PMID: 26501340 Free PMC article. Review.
As emerging research uncovers the function of each LARP, it is evident that La, LARP1, LARP6, LARP7 and possibly LARP4a and 4b are dysregulated in cancer. Of these, LARP1 is the first to be demonstrated to drive oncogenesis. ...We discuss a future strategy of targeting mem …
As emerging research uncovers the function of each LARP, it is evident that La, LARP1, LARP6, LARP7 and possibly LARP4a and 4b are dysregula …
MicroRNA-106b functions as an oncogene and regulates tumor viability and metastasis by targeting LARP4B in prostate cancer.
Yin W, Chen J, Wang G, Zhang D. Yin W, et al. Mol Med Rep. 2019 Aug;20(2):951-958. doi: 10.3892/mmr.2019.10343. Epub 2019 Jun 5. Mol Med Rep. 2019. PMID: 31173237 Free PMC article.
Prostate cancer (PCa) is the most common malignancy among males worldwide, and is one of the leading causes of cancer-related mortality. ...In addition, LARP4B was identified as a target gene of miR-106b by bioinformatics prediction analysis and a dual lucife …
Prostate cancer (PCa) is the most common malignancy among males worldwide, and is one of the leading causes of cancer-related …
Identification of RNA-Binding Protein LARP4B as a Tumor Suppressor in Glioma.
Koso H, Yi H, Sheridan P, Miyano S, Ino Y, Todo T, Watanabe S. Koso H, et al. Cancer Res. 2016 Apr 15;76(8):2254-64. doi: 10.1158/0008-5472.CAN-15-2308. Epub 2016 Mar 1. Cancer Res. 2016. PMID: 26933087
Moreover, heterozygous deletion of LARP4B was detected in nearly 80% of glioblastomas in The Cancer Genome Atlas database. ...Cancer Res; 76(8); 2254-64. 2016 AACR....
Moreover, heterozygous deletion of LARP4B was detected in nearly 80% of glioblastomas in The Cancer Genome Atlas database. ... …
The RNA binding proteins LARP4A and LARP4B promote sarcoma and carcinoma growth and metastasis.
Coleman JC, Tattersall L, Yianni V, Knight L, Yu H, Hallett SR, Johnson P, Caetano AJ, Cosstick C, Ridley AJ, Gartland A, Conte MR, Grigoriadis AE. Coleman JC, et al. iScience. 2024 Feb 24;27(4):109288. doi: 10.1016/j.isci.2024.109288. eCollection 2024 Apr 19. iScience. 2024. PMID: 38532886 Free PMC article.
RNA-binding proteins (RBPs) are emerging as important regulators of cancer pathogenesis. We reveal that the RBPs LARP4A and LARP4B are differentially overexpressed in osteosarcoma and osteosarcoma lung metastases, as well as in prostate cancer. ...This first …
RNA-binding proteins (RBPs) are emerging as important regulators of cancer pathogenesis. We reveal that the RBPs LARP4A and LARP4B …
La-related protein 4B maintains murine MLL-AF9 leukemia stem cell self-renewal by regulating cell cycle progression.
Zhang Y, Peng L, Hu T, Wan Y, Ren Y, Zhang J, Wang X, Zhou Y, Yuan W, Wang Q, Cheng T, Zhu X. Zhang Y, et al. Exp Hematol. 2015 Apr;43(4):309-18.e2. doi: 10.1016/j.exphem.2014.12.003. Epub 2014 Dec 20. Exp Hematol. 2015. PMID: 25534202 Free article.
To study the role of LARP4B in AML, we established a LARP4B-knockdown MLL-AF9 AML mouse model. ...Cell cycle analysis revealed that LARP4B knockdown arrested more LSCs in the G0 phase. The transcription of the cell cycle inhibitors p16, p19, and p21 and of th …
To study the role of LARP4B in AML, we established a LARP4B-knockdown MLL-AF9 AML mouse model. ...Cell cycle analysis revealed …
A pan-cancer genome-wide analysis reveals tumour dependencies by induction of nonsense-mediated decay.
Hu Z, Yau C, Ahmed AA. Hu Z, et al. Nat Commun. 2017 Jun 26;8:15943. doi: 10.1038/ncomms15943. Nat Commun. 2017. PMID: 28649990 Free PMC article.
Although NMD-induced loss-of-function has been shown to contribute to the genesis of particular cancers, its global functional consequence in tumours has not been characterized. ...NMD-elicit mutations in tumour suppressor genes (TSGs) are associated with significant reduc …
Although NMD-induced loss-of-function has been shown to contribute to the genesis of particular cancers, its global functional conseq …
14 results