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Long noncoding RNA CASC9 promotes LIN7A expression via miR-758-3p to facilitate the malignancy of ovarian cancer.
Hu X, Li Y, Kong D, Hu L, Liu D, Wu J. Hu X, et al. J Cell Physiol. 2019 Jul;234(7):10800-10808. doi: 10.1002/jcp.27903. Epub 2018 Dec 7. J Cell Physiol. 2019. PMID: 30537154
We showed that CASC9 works as a competing endogenous RNA (ceRNA) for miR-758-3p which targets LIN7A. CASC9 inhibits the level of miR-758-3p, and in turn stimulates LIN7A expression in ovarian cancer. Overexpression of LIN7A reverses the suppressive rol …
We showed that CASC9 works as a competing endogenous RNA (ceRNA) for miR-758-3p which targets LIN7A. CASC9 inhibits the level of miR- …
LIN7A is a major determinant of cell-polarity defects in breast carcinomas.
Gruel N, Fuhrmann L, Lodillinsky C, Benhamo V, Mariani O, Cédenot A, Arnould L, Macgrogan G, Sastre-Garau X, Chavrier P, Delattre O, Vincent-Salomon A. Gruel N, et al. Breast Cancer Res. 2016 Feb 17;18(1):23. doi: 10.1186/s13058-016-0680-x. Breast Cancer Res. 2016. PMID: 26887652 Free PMC article.
Upon LIN7A over-expression, we observed hyperproliferation, invasion and a complete absence of lumen formation, revealing strong polarity defects. CONCLUSION: This study therefore shows that LIN7A has a crucial role in the polarity abnormalities associated with brea …
Upon LIN7A over-expression, we observed hyperproliferation, invasion and a complete absence of lumen formation, revealing strong pola …
DNA methylation landscape reveals LIN7A as a decitabine-responsive marker in patients with t(8;21) acute myeloid leukemia.
He S, Li Y, Shi X, Wang L, Cai D, Zhou J, Yu L. He S, et al. Clin Epigenetics. 2023 Mar 3;15(1):37. doi: 10.1186/s13148-023-01458-0. Clin Epigenetics. 2023. PMID: 36864492 Free PMC article.
Moreover, AML patients with hypermethylated LIN7A and reduced LIN7A expression had poor clinical outcomes. Meanwhile, the downregulation of LIN7A inhibited decitabine/cytarabine combination treatment-induced apoptosis in t(8;21) AML cells in vitro. CONCLUSION …
Moreover, AML patients with hypermethylated LIN7A and reduced LIN7A expression had poor clinical outcomes. Meanwhile, the down …
microRNA-501-3p suppresses metastasis and progression of hepatocellular carcinoma through targeting LIN7A.
Luo C, Yin D, Zhan H, Borjigin U, Li C, Zhou Z, Hu Z, Wang P, Sun Q, Fan J, Zhou J, Wang X, Zhou S, Huang X. Luo C, et al. Cell Death Dis. 2018 May 1;9(5):535. doi: 10.1038/s41419-018-0577-y. Cell Death Dis. 2018. PMID: 29749382 Free PMC article.
Results of functional analyses revealed that overexpression of miR-501-3p in HCCLM3 cancer cells inhibited their proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT), while miR-501-3p loss in PLC/PRF/5 cancer cells facilitated all these ce …
Results of functional analyses revealed that overexpression of miR-501-3p in HCCLM3 cancer cells inhibited their proliferation, migra …
A novel investigation into the negative impact of opioid use on the efficacy of immune checkpoint inhibitors in advanced non-small cell lung cancer patients.
Guo H, Li Y, Lin J, Li D, Yang J, Wang J, Mao J, Wang Y, Yan X. Guo H, et al. Int Immunopharmacol. 2024 Mar 10;129:111611. doi: 10.1016/j.intimp.2024.111611. Epub 2024 Feb 6. Int Immunopharmacol. 2024. PMID: 38325047
OBJECTIVE: Immune checkpoint inhibitors (ICIs) have effectively improved the clinical outcome of advanced non-small cell lung cancer (NSCLC). Opioids are commonly used for pain relief in cancer patients. ...The bioinformatic analysis identified 14 prognostic OTGs (C …
OBJECTIVE: Immune checkpoint inhibitors (ICIs) have effectively improved the clinical outcome of advanced non-small cell lung cancer …
The loss of DLG2 isoform 7/8, but not isoform 2, is critical in advanced staged neuroblastoma.
Keane S, Martinsson T, Kogner P, Ejeskär K. Keane S, et al. Cancer Cell Int. 2021 Mar 16;21(1):170. doi: 10.1186/s12935-021-01851-w. Cancer Cell Int. 2021. PMID: 33726762 Free PMC article.
We could show that the protein encoded by DLG2-isoform 7 could bind to LIN7A, and increased DLG2-isoform 7 gene expression increased the expression of LIN7A, this reduced neuroblastoma cell proliferation and viability, with increased BAX/BCL2 ratio indicating increa …
We could show that the protein encoded by DLG2-isoform 7 could bind to LIN7A, and increased DLG2-isoform 7 gene expression increased …
Identification of Crucial Candidate Genes and Pathways in Glioblastoma Multiform by Bioinformatics Analysis.
Alshabi AM, Vastrad B, Shaikh IA, Vastrad C. Alshabi AM, et al. Biomolecules. 2019 May 24;9(5):201. doi: 10.3390/biom9050201. Biomolecules. 2019. PMID: 31137733 Free PMC article.
A total of 590 DEGs, including 243 up regulated and 347 down regulated genes, were diagnosed between scrambled shRNA expression and Lin7A knock down. The up-regulated genes were enriched in ribosome, mitochondrial translation termination, translation, and peptide biosynthe …
A total of 590 DEGs, including 243 up regulated and 347 down regulated genes, were diagnosed between scrambled shRNA expression and Lin7A …
Molecular Pathology of Micropapillary Carcinomas: Is Characteristic Morphology Related to Molecular Mechanisms?
Sagnak Yilmaz Z, Sarioglu S. Sagnak Yilmaz Z, et al. Appl Immunohistochem Mol Morphol. 2023 May-Jun 01;31(5):267-277. doi: 10.1097/PAI.0000000000001123. Epub 2023 Apr 11. Appl Immunohistochem Mol Morphol. 2023. PMID: 37036419 Review.
Among the proteins that affect cell polarity, RAC1, placoglobin, as well as CLDNs, LIN7A, ZEB1, CLDN1, DLG1, CDH1 (E-cadherin), OCLN, AFDN/AF6, ZEB1, SNAI2, ITGA1 (integrin alpha 1), ITGB1 (integrin beta 1), RHOA, Jagged-1 (JAG1) mRNAs differentially express between IMPC a …
Among the proteins that affect cell polarity, RAC1, placoglobin, as well as CLDNs, LIN7A, ZEB1, CLDN1, DLG1, CDH1 (E-cadherin), OCLN, …
Identification and characterization of human MPP7 gene and mouse Mpp7 gene in silico.
Katoh M, Katoh M. Katoh M, et al. Int J Mol Med. 2004 Feb;13(2):333-8. Int J Mol Med. 2004. PMID: 14719143
Because epithelial polarity is disrupted in tumors, human homologs of Drosophila crb, sdt, dlg, scrib, and lgl are potential cancer-associated genes. MPP1/EMP55, MPP2, MPP3, MPP4, MPP5/PALS1 and MPP6/PALS2 genes are human homologs of Drosoplila sdt. ...MPP7 was most relate …
Because epithelial polarity is disrupted in tumors, human homologs of Drosophila crb, sdt, dlg, scrib, and lgl are potential cancer-a …
Multi-Ancestry Genome-wide Association Study Accounting for Gene-Psychosocial Factor Interactions Identifies Novel Loci for Blood Pressure Traits.
Sun D, Richard M, Musani SK, Sung YJ, Winkler TW, Schwander K, Chai JF, Guo X, Kilpeläinen TO, Vojinovic D, Aschard H, Bartz TM, Bielak LF, Brown MR, Chitrala K, Hartwig FP, Horimoto ARVR, Liu Y, Manning AK, Noordam R, Smith AV, Harris SE, Kühnel B, Lyytikäinen LP, Nolte IM, Rauramaa R, van der Most PJ, Wang R, Ware EB, Weiss S, Wen W, Yanek LR, Arking DE, Arnett DK, Barac A, Boerwinkle E, Broeckel U, Chakravarti A, Chen YI, Cupples LA, Davigulus ML, de Las Fuentes L, de Mutsert R, de Vries PS, Delaney JAC, Roux AVD, Dörr M, Faul JD, Fretts AM, Gallo LC, Grabe HJ, Gu CC, Harris TB, Hartman CCA, Heikkinen S, Ikram MA, Isasi C, Johnson WC, Jonas JB, Kaplan RC, Komulainen P, Krieger JE, Levy D; Lifelines Cohort Study; Liu J, Lohman K, Luik AI, Martin LW, Meitinger T, Milaneschi Y, O'Connell JR, Palmas WR, Peters A, Peyser PA, Pulkki-Råback L, Raffel LJ, Reiner AP, Rice K, Robinson JG, Rosendaal FR, Schmidt CO, Schreiner PJ, Schwettmann L, Shikany JM, Shu XO, Sidney S, Sims M, Smith JA, Sotoodehnia N, Strauch K, Tai ES, Taylor K, Uitterlinden AG, van Duijn CM, Waldenberger M, Wee HL, Wei WB, Wilson G, Xuan D, Yao J, Zeng D, Zhao W, Zhu X, Zonderman AB, Becker DM, Deary IJ, Gieger C, L… See abstract for full author list ➔ Sun D, et al. HGG Adv. 2021 Jan 14;2(1):100013. doi: 10.1016/j.xhgg.2020.100013. Epub 2020 Oct 31. HGG Adv. 2021. PMID: 34734193 Free PMC article.
Functional annotation of the novel loci supports a major role for genes implicated in the immune response (PLCL2), synaptic function and neurotransmission (LIN7A, PFIA2), as well as genes previously implicated in neuropsychiatric or stress-related disorders (FSTL5, CHODL). …
Functional annotation of the novel loci supports a major role for genes implicated in the immune response (PLCL2), synaptic function and neu …
12 results