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LMCD1 antisense RNA 1 (LMCD1-AS1) potentiates thyroid cancer cell growth and stemness via a positive feedback loop of LMCD1-AS1/miR-1287-5p/GLI2.
Shao J, Xu Y, Li H, Chen L, Wang W, Shen D, Chen J. Shao J, et al. Ann Transl Med. 2020 Nov;8(22):1508. doi: 10.21037/atm-20-7182. Ann Transl Med. 2020. PMID: 33313253 Free PMC article.
BACKGROUND: LMCD1 antisense RNA 1 (LMCD1-AS1) is a certified oncogene in several tumour types. ...Cytoplasmic LMCD1-AS1 sponged a shared microRNA between LMCD1-AS1 and GLI2. GLI2 was inhibited bymiR-1287-5p and disinhibited by LMCD1-AS1. ...
BACKGROUND: LMCD1 antisense RNA 1 (LMCD1-AS1) is a certified oncogene in several tumour types. ...Cytoplasmic LMCD1-AS1 …
LMCD1 antisense RNA 1 is a newly identified long noncoding RNA.
Yalman N. Yalman N. Anticancer Drugs. 2022 Jan 1;33(1):1-5. doi: 10.1097/CAD.0000000000001124. Anticancer Drugs. 2022. PMID: 34232945
GLI2 is shown to bind to the LMCD1-AS1 promoter and is transcriptionally activated by LMCD1-AS1. ...Also, LMCD1-AS1 functions in thyroid cancer (THCA) development. LMCD1-AS1 is overexpressed in THCA cells, and LMCD1-AS1 knockdown suppress …
GLI2 is shown to bind to the LMCD1-AS1 promoter and is transcriptionally activated by LMCD1-AS1. ...Also, LMCD1-AS1 fun …
LMCD1-AS1 Facilitates Cell Proliferation and EMT by Sponging miR-873-3p in Cervical Cancer.
Liang M, Li Y, Chen C. Liang M, et al. Crit Rev Eukaryot Gene Expr. 2023;33(2):13-25. doi: 10.1615/CritRevEukaryotGeneExpr.2022042882. Crit Rev Eukaryot Gene Expr. 2023. PMID: 36734854
Long non-coding RNA LMCD1 antisense RNA 1 (LMCD1-AS1) has recently been reported to participate in the pathogenesis of several tumors, including thyroid cancer and osteosarcoma. However, the clinical significance of LMCD1-AS1 and the related biological …
Long non-coding RNA LMCD1 antisense RNA 1 (LMCD1-AS1) has recently been reported to participate in the pathogenesis of several …
The LMCD1-AS1/miR-526b-3p/OSBPL5 axis promotes cell proliferation, migration and invasion in non-small cell lung cancer.
Hu R, Yu Y, Wang H. Hu R, et al. BMC Pulm Med. 2022 Jan 9;22(1):30. doi: 10.1186/s12890-022-01820-7. BMC Pulm Med. 2022. PMID: 35000595 Free PMC article. Retracted.
Additionally, by performing qRT-PCR analysis, luciferase reporter and RNA pull-down assays, we verified that OSBPL5 was a downstream target of miR-526b-3p and long noncoding RNA (lncRNA) LMCD1-AS1 served as a sponge for miR-526b-3p. Moreover, from rescue assays, we observe …
Additionally, by performing qRT-PCR analysis, luciferase reporter and RNA pull-down assays, we verified that OSBPL5 was a downstream target …
LIM and cysteine-rich domains 1 (LMCD1) regulates skeletal muscle hypertrophy, calcium handling, and force.
Ferreira DMS, Cheng AJ, Agudelo LZ, Cervenka I, Chaillou T, Correia JC, Porsmyr-Palmertz M, Izadi M, Hansson A, Martínez-Redondo V, Valente-Silva P, Pettersson-Klein AT, Estall JL, Robinson MM, Nair KS, Lanner JT, Ruas JL. Ferreira DMS, et al. Skelet Muscle. 2019 Oct 31;9(1):26. doi: 10.1186/s13395-019-0214-1. Skelet Muscle. 2019. PMID: 31666122 Free PMC article.
In fact, it is predicted that controlling muscle atrophy can reduce morbidity and mortality associated with diseases such as cancer cachexia and sarcopenia. METHODS: We analyzed gene expression data from muscle of mice or human patients with diverse muscle pathologies and …
In fact, it is predicted that controlling muscle atrophy can reduce morbidity and mortality associated with diseases such as cancer c …
E2F1-induced upregulation of long non-coding RNA LMCD1-AS1 facilitates cholangiocarcinoma cell progression by regulating miR-345-5p/COL6A3 pathway.
Yu J, Zhang B, Zhang H, Qi Y, Wang Y, Wang W, Wang Y, Wang Y. Yu J, et al. Biochem Biophys Res Commun. 2019 Apr 30;512(2):150-155. doi: 10.1016/j.bbrc.2019.03.054. Epub 2019 Mar 13. Biochem Biophys Res Commun. 2019. PMID: 30876691
E2F1 could bind directly to the promoter region of LMCD1-AS1 and activate its transcription. Function study showed depletion of LMCD1-AS1 suppressed cell proliferation, clone formation and invasion, and induced apoptosis of CCA cells. Whereas, ectopic expressed L …
E2F1 could bind directly to the promoter region of LMCD1-AS1 and activate its transcription. Function study showed depletion of LM …
SP1-mediated upregulation of lncRNA LMCD1-AS1 functions a ceRNA for miR-106b-5p to facilitate osteosarcoma progression.
He JW, Li DJ, Zhou JH, Zhu YL, Yu BQ. He JW, et al. Biochem Biophys Res Commun. 2020 Jun 4;526(3):670-677. doi: 10.1016/j.bbrc.2020.03.151. Epub 2020 Apr 2. Biochem Biophys Res Commun. 2020. PMID: 32248969
Growing studies have indicated the involvements of long noncoding RNAs (lncRNAs) in the initiation and progression of various tumors. We aimed to investigated the role of lncRNA LMCD1 antisense RNA 1 (LMCD1-AS1) in osteosarcoma development. We found that LMCD1 …
Growing studies have indicated the involvements of long noncoding RNAs (lncRNAs) in the initiation and progression of various tumors. We aim …
Somatic LMCD1 mutations promoted cell migration and tumor metastasis in hepatocellular carcinoma.
Chang CY, Lin SC, Su WH, Ho CM, Jou YS. Chang CY, et al. Oncogene. 2012 May 24;31(21):2640-52. doi: 10.1038/onc.2011.440. Epub 2011 Sep 26. Oncogene. 2012. PMID: 21996735
Common genetic alteration in cancer genomes is implicated for embracing an aberrant cancer gene participated in tumor progression. ...In PLC/PRF/5 cells with endogenous K237R mutation, cell migration was enhanced by estrogen-induced LMCD1 expression but rever …
Common genetic alteration in cancer genomes is implicated for embracing an aberrant cancer gene participated in tumor progress …
Integrated Multi-Omics Signature Predicts Survival in Head and Neck Cancer.
Ribeiro IP, Esteves L, Caramelo F, Carreira IM, Melo JB. Ribeiro IP, et al. Cells. 2022 Aug 16;11(16):2536. doi: 10.3390/cells11162536. Cells. 2022. PMID: 36010616 Free PMC article.
Head and Neck Cancer (HNC) is characterized by phenotypic, biological, and clinical heterogeneity. ...This prognosis multi-omic signature comprises genes mapped in the chromosomes 1q, 3p, 8q, 17q, 19p, and 19q and encompasses alterations at copy number, gene expression, an …
Head and Neck Cancer (HNC) is characterized by phenotypic, biological, and clinical heterogeneity. ...This prognosis multi-omic signa …
16 results