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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 1
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2004 4
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2008 8
2009 13
2010 4
2011 9
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2014 15
2015 19
2016 14
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225 results

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LRIG1 expression and colorectal cancer prognosis.
Bakherad M, Salimi M, Angaji SA, Mahjoubi F, Majidizadeh T. Bakherad M, et al. BMC Med Genomics. 2021 Jan 18;14(1):20. doi: 10.1186/s12920-020-00846-2. BMC Med Genomics. 2021. PMID: 33461538 Free PMC article.
However, in many cases this data is not enough. Some studies suggest that LRIG1 gene (leucine-rich repeats and immunoglobulin-like domains1) has prognostic implications in different kinds of cancers. METHODS: One hundred and two patients with colorectal cancer …
However, in many cases this data is not enough. Some studies suggest that LRIG1 gene (leucine-rich repeats and immunoglobulin-like do …
Harnessing LRIG1-mediated inhibition of receptor tyrosine kinases for cancer therapy.
Neirinckx V, Hedman H, Niclou SP. Neirinckx V, et al. Biochim Biophys Acta Rev Cancer. 2017 Aug;1868(1):109-116. doi: 10.1016/j.bbcan.2017.02.007. Epub 2017 Mar 1. Biochim Biophys Acta Rev Cancer. 2017. PMID: 28259645 Review.
Leucine-rich repeats and immunoglobulin-like domains containing protein 1 (LRIG1) is an endogenous feedback regulator of receptor tyrosine kinases (RTKs) and was recently shown to inhibit growth of different types of malignancies. ...This mini-review provides a concise and …
Leucine-rich repeats and immunoglobulin-like domains containing protein 1 (LRIG1) is an endogenous feedback regulator of receptor tyr …
Aberrant promoter methylation contributes to LRIG1 silencing in basal/triple-negative breast cancer.
Umeh-Garcia M, O'Geen H, Simion C, Gephart MH, Segal DJ, Sweeney CA. Umeh-Garcia M, et al. Br J Cancer. 2022 Aug;127(3):436-448. doi: 10.1038/s41416-022-01812-8. Epub 2022 Apr 19. Br J Cancer. 2022. PMID: 35440669 Free PMC article.
However, mechanisms by which LRIG1 is repressed are not fully understood. Silencing of LRIG1 through promoter CpG island methylation has been reported in colorectal and cervical cancer but studies in breast cancer remain limited. ...Our findings sugges …
However, mechanisms by which LRIG1 is repressed are not fully understood. Silencing of LRIG1 through promoter CpG island methy …
LRIG and cancer prognosis.
Lindquist D, Kvarnbrink S, Henriksson R, Hedman H. Lindquist D, et al. Acta Oncol. 2014 Sep;53(9):1135-42. doi: 10.3109/0284186X.2014.953258. Epub 2014 Sep 2. Acta Oncol. 2014. PMID: 25180912 Free PMC article. Review.
LRIG gene and protein expression are commonly dysregulated in human cancer. In early stage breast cancer, LRIG1 copy number was recently shown to predict early and late relapse in addition to overall survival; in nasopharyngeal carcinoma, loss of LRIG1 …
LRIG gene and protein expression are commonly dysregulated in human cancer. In early stage breast cancer, LRIG1 copy nu …
LRIG1, a regulator of stem cell quiescence and a pleiotropic feedback tumor suppressor.
Ji Y, Kumar R, Gokhale A, Chao HP, Rycaj K, Chen X, Li Q, Tang DG. Ji Y, et al. Semin Cancer Biol. 2022 Jul;82:120-133. doi: 10.1016/j.semcancer.2020.12.016. Epub 2021 Jan 18. Semin Cancer Biol. 2022. PMID: 33476721 Free PMC article. Review.
We have recently reported that in treatment-naive human prostate cancer (PCa), LRIG1 is primarily regulated by androgen receptor (AR) and is prominently overexpressed. ...We further highlight the expression, regulation and functions of LRIG1 in treatment-naiv …
We have recently reported that in treatment-naive human prostate cancer (PCa), LRIG1 is primarily regulated by androgen recept …
LRIG1 is a pleiotropic androgen receptor-regulated feedback tumor suppressor in prostate cancer.
Li Q, Liu B, Chao HP, Ji Y, Lu Y, Mehmood R, Jeter C, Chen T, Moore JR, Li W, Liu C, Rycaj K, Tracz A, Kirk J, Calhoun-Davis T, Xiong J, Deng Q, Huang J, Foster BA, Gokhale A, Chen X, Tang DG. Li Q, et al. Nat Commun. 2019 Dec 2;10(1):5494. doi: 10.1038/s41467-019-13532-4. Nat Commun. 2019. PMID: 31792211 Free PMC article.
However, little is known about the expression, regulation and biological functions of LRIG1 in prostate cancer (PCa). We find that LRIG1 is overexpressed in PCa, but its expression correlates with better patient survival. ...We further show that 1) AR directl …
However, little is known about the expression, regulation and biological functions of LRIG1 in prostate cancer (PCa). We find …
An oncogenic phenoscape of colonic stem cell polarization.
Qin X, Cardoso Rodriguez F, Sufi J, Vlckova P, Claus J, Tape CJ. Qin X, et al. Cell. 2023 Dec 7;186(25):5554-5568.e18. doi: 10.1016/j.cell.2023.11.004. Cell. 2023. PMID: 38065080 Free article.
Cancer cells are regulated by oncogenic mutations and microenvironmental signals, yet these processes are often studied separately. To functionally map how cell-intrinsic and cell-extrinsic cues co-regulate cell fate, we performed a systematic single-cell analysis of 1,107 …
Cancer cells are regulated by oncogenic mutations and microenvironmental signals, yet these processes are often studied separately. T …
LRIG1 gene copy number analysis by ddPCR and correlations to clinical factors in breast cancer.
Faraz M, Tellström A, Ardnor CE, Grankvist K, Huminiecki L, Tavelin B, Henriksson R, Hedman H, Ljuslinder I. Faraz M, et al. BMC Cancer. 2020 May 24;20(1):459. doi: 10.1186/s12885-020-06919-w. BMC Cancer. 2020. PMID: 32448168 Free PMC article.
Importantly, LRIG1 loss was recently shown to predict early and late relapse in stage I-II breast cancer. ...CONCLUSIONS: Although LRIG1 gene aberrations may be important determinants of breast cancer biology, and prognostic markers, the results of thi …
Importantly, LRIG1 loss was recently shown to predict early and late relapse in stage I-II breast cancer. ...CONCLUSIONS: Alth …
LRIG1 negatively regulates RET mutants and is downregulated in thyroid cancer.
Lindquist D, Alsina FC, Herdenberg C, Larsson C, Höppener J, Wang N, Paratcha G, Tarján M, Tot T, Henriksson R, Hedman H. Lindquist D, et al. Int J Oncol. 2018 Apr;52(4):1189-1197. doi: 10.3892/ijo.2018.4273. Epub 2018 Feb 9. Int J Oncol. 2018. PMID: 29436694 Free PMC article.
LRIG1 expression levels are associated with patient survival in many cancer types. ...There was no significant difference in the incidence of pre-cancerous lesions between Lrig1 wild-type and Lrig1-deficient RET2B mice. ...
LRIG1 expression levels are associated with patient survival in many cancer types. ...There was no significant difference in t …
LRIG1 expression in colorectal cancer.
Ljuslinder I, Golovleva I, Palmqvist R, Oberg A, Stenling R, Jonsson Y, Hedman H, Henriksson R, Malmer B. Ljuslinder I, et al. Acta Oncol. 2007;46(8):1118-22. doi: 10.1080/02841860701426823. Acta Oncol. 2007. PMID: 17851870
FISH (fluoroscence in situ hybridisAtion) analysis showed increased LRIG1 copy number in one of nine tumours. Four colorectal cancer cell lines demonstrated two LRIG1 gene copies. In conclusion, there was a great heterogeneity in the expression of the LRIG …
FISH (fluoroscence in situ hybridisAtion) analysis showed increased LRIG1 copy number in one of nine tumours. Four colorectal canc …
225 results