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Year Number of Results
2004 1
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2011 3
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LRIG2 promotes glioblastoma progression by modulating innate antitumor immunity through macrophage infiltration and polarization.
Hu J, Dong F, He Y, Xia X, Cheng F, Chen S, Hou X, Zhang P, Liu G, Li Y, Gao Q, Dong M, Li T, Li W, Xiao Q, Li X, Yu X, Xi G, Guo D, Wu X, Wang B. Hu J, et al. J Immunother Cancer. 2022 Sep;10(9):e004452. doi: 10.1136/jitc-2021-004452. J Immunother Cancer. 2022. PMID: 36096529 Free PMC article.
Immunotherapy has recently been an attractive and promising treatment of extracranial malignancies, however, most of clinical trials for GBM immunotherapy failed due to predominant accumulation of tumor-associated microglia/macrophages (TAMs). RESULTS: High level of LRIG2/ …
Immunotherapy has recently been an attractive and promising treatment of extracranial malignancies, however, most of clinical trials for GBM …
LRIG and cancer prognosis.
Lindquist D, Kvarnbrink S, Henriksson R, Hedman H. Lindquist D, et al. Acta Oncol. 2014 Sep;53(9):1135-42. doi: 10.3109/0284186X.2014.953258. Epub 2014 Sep 2. Acta Oncol. 2014. PMID: 25180912 Free PMC article. Review.
The functions of LRIG2 and LRIG3 are less well defined. LRIG gene and protein expression are commonly dysregulated in human cancer. ...LRIG gene and protein expression have prognostic value in breast cancer, uterine cervical cancer, head-and-neck ca …
The functions of LRIG2 and LRIG3 are less well defined. LRIG gene and protein expression are commonly dysregulated in human cancer …
LRIG2 expression and prognosis in non-small cell lung cancer.
Wang G, Wu J, Song H. Wang G, et al. Oncol Lett. 2014 Aug;8(2):667-672. doi: 10.3892/ol.2014.2157. Epub 2014 May 19. Oncol Lett. 2014. PMID: 25013483 Free PMC article.
The human leucine-rich repeats and immunoglobulin-like domains 2 (LRIG2) protein has been shown to be of prognostic value in several types of human cancer, however, the expression profiles of LRIG2 have not been described in non-small cell lung cancer …
The human leucine-rich repeats and immunoglobulin-like domains 2 (LRIG2) protein has been shown to be of prognostic value in several …
LRIG2 regulates cell proliferation, migration and apoptosis of osteosarcoma.
Li ZQ, Liao WJ, Sun BL, Luo ZW, Zhong NS, Wu JB, Liu ZL, Liu JM. Li ZQ, et al. BMC Cancer. 2022 Oct 1;22(1):1029. doi: 10.1186/s12885-022-10123-3. BMC Cancer. 2022. PMID: 36183058 Free PMC article.
Silencing LRIG2 also suppressed the growth of subcutaneous transplanted tumor in nude mice. ...Additionally, silencing LRIG2 significantly decreased the rate of tumor growth and tumor size. ...
Silencing LRIG2 also suppressed the growth of subcutaneous transplanted tumor in nude mice. ...Additionally, silencing LRIG2 s …
LncRNA-PCAT-1 promotes non-small cell lung cancer progression by regulating miR-149-5p/LRIG2 axis.
Li J, Li Y, Wang B, Ma Y, Chen P. Li J, et al. J Cell Biochem. 2019 May;120(5):7725-7733. doi: 10.1002/jcb.28046. Epub 2018 Dec 19. J Cell Biochem. 2019. PMID: 30569478
Long noncoding RNAs (lncRNAs) are key players in the development and progression of human cancers. The lncRNA PCAT-1 has been shown to be upregulated in human non-small cell lung cancer (NSCLC); however, its role and molecular mechanisms in NSCLC cell progression re …
Long noncoding RNAs (lncRNAs) are key players in the development and progression of human cancers. The lncRNA PCAT-1 has been shown t …
The transmembrane protein LRIG2 increases tumor progression in skin carcinogenesis.
Hoesl C, Fröhlich T, Hundt JE, Kneitz H, Goebeler M, Wolf R, Schneider MR, Dahlhoff M. Hoesl C, et al. Mol Oncol. 2019 Nov;13(11):2476-2492. doi: 10.1002/1878-0261.12579. Epub 2019 Oct 21. Mol Oncol. 2019. PMID: 31580518 Free PMC article.
LRIG2 was identified to be up-regulated in various types of squamous cell carcinoma (SCC), but little is known about LRIG2 in cutaneous SCC (cSCC). To investigate the function of LRIG2 in cSCC in vivo, we generated a skin-specific LRIG2 overexpressing …
LRIG2 was identified to be up-regulated in various types of squamous cell carcinoma (SCC), but little is known about LRIG2 in …
Notch1 targeted regulation of mir-224/LRIG2 signaling for the proliferation and apoptosis of cervical cancer cells.
Cong L, Zhang F, Shang H. Cong L, et al. Oncol Lett. 2017 Apr;13(4):2304-2308. doi: 10.3892/ol.2017.5676. Epub 2017 Feb 3. Oncol Lett. 2017. PMID: 28454395 Free PMC article.
In the present study, we explored the participation of Notch1 targeted regulation of mir-224/LRIG2 gene signal pathway in proliferation and apoptosis of cervical cancer cells. ...We determined the mRNA and protein expression of Notch1, mir-224, and LRIG2 gene …
In the present study, we explored the participation of Notch1 targeted regulation of mir-224/LRIG2 gene signal pathway in proliferati …
CircRNA hsa_circRNA_0001776 inhibits proliferation and promotes apoptosis in endometrial cancer via downregulating LRIG2 by sponging miR-182.
Jia Y, Liu M, Wang S. Jia Y, et al. Cancer Cell Int. 2020 Aug 26;20:412. doi: 10.1186/s12935-020-01437-y. eCollection 2020. Cancer Cell Int. 2020. PMID: 32863771 Free PMC article.
BACKGROUND: Endometrial cancer (EC) is a common malignancy of the female reproductive system. ...Bioinformatics analysis and dual-luciferase reporter assay were used to determine the interaction among circ_0001776, miR-182 and LRIG2. The protein expression of LRI …
BACKGROUND: Endometrial cancer (EC) is a common malignancy of the female reproductive system. ...Bioinformatics analysis and dual-luc …
Targeting LRIG2 overcomes resistance to EGFR inhibitor in glioblastoma by modulating GAS6/AXL/SRC signaling.
Dong M, Xiao Q, Hu J, Cheng F, Zhang P, Zong W, Tang Q, Li X, Mao F, He Y, Yu X, Wan F, Lei T, Guo D, Wang B. Dong M, et al. Cancer Gene Ther. 2020 Dec;27(12):878-897. doi: 10.1038/s41417-020-0163-1. Epub 2020 Jan 28. Cancer Gene Ther. 2020. PMID: 31988476
We therefore hypothesized that LRIG2 might mediate the resistance to EGFR inhibitor through modulating other RTK signaling. ...Targeting LRIG2 significantly sensitizes the GBM cells to gefitinib, and inhibition of the downstream GAS6/AXL/SRC signaling abrogates L …
We therefore hypothesized that LRIG2 might mediate the resistance to EGFR inhibitor through modulating other RTK signaling. ...Target …
Neurogenic Defects Occur in LRIG2-Associated Urinary Bladder Disease.
Grenier C, Lopes FM, Cueto-González AM, Rovira-Moreno E, Gander R, Jarvis BW, McCloskey KD, Gurney AM, Beaman GM, Newman WG, Woolf AS, Roberts NA. Grenier C, et al. Kidney Int Rep. 2023 Apr 30;8(7):1417-1429. doi: 10.1016/j.ekir.2023.04.017. eCollection 2023 Jul. Kidney Int Rep. 2023. PMID: 37441484 Free PMC article.
We hypothesized that peripheral neurogenic defects underlie LRIG2-associated bladder dysfunction. METHODS: We describe a new family with LRIG2-associated UFS and studied Lrig2 homozygous mutant mice with ex vivo physiological analyses. ...Although HPSE2 seque …
We hypothesized that peripheral neurogenic defects underlie LRIG2-associated bladder dysfunction. METHODS: We describe a new family w …
50 results