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Page 1
Structure and regulation of full-length human leucine-rich repeat kinase 1.
Metcalfe RD, Martinez Fiesco JA, Bonet-Ponce L, Kluss JH, Cookson MR, Zhang P. Metcalfe RD, et al. Nat Commun. 2023 Aug 9;14(1):4797. doi: 10.1038/s41467-023-40532-2. Nat Commun. 2023. PMID: 37558661 Free PMC article.
Structures of LRRK2 have recently been determined, but the structure and molecular mechanisms regulating the activity of the LRRK1 as well as differences in the regulation of LRRK1 and LRRK2 remain unclear. Here, we report a cryo-EM structure of the LRRK1 mon …
Structures of LRRK2 have recently been determined, but the structure and molecular mechanisms regulating the activity of the LRRK1 as …
Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes.
Sejwal K, Chami M, Rémigy H, Vancraenenbroeck R, Sibran W, Sütterlin R, Baumgartner P, McLeod R, Chartier-Harlin MC, Baekelandt V, Stahlberg H, Taymans JM. Sejwal K, et al. Sci Rep. 2017 Aug 17;7(1):8667. doi: 10.1038/s41598-017-09126-z. Sci Rep. 2017. PMID: 28819229 Free PMC article.
Next, analysis of the 3D maps generated from the cryo-EM data show 16 and 25 A resolution structures of full length LRRK2 and LRRK1, respectively, revealing the overall shape of the dimers with two-fold symmetric orientations of the protomers that is closely similar betwee …
Next, analysis of the 3D maps generated from the cryo-EM data show 16 and 25 A resolution structures of full length LRRK2 and LRRK1, …
The landscape of cryptic antisense transcription in human cancers reveals an oncogenic noncoding RNA in lung cancer.
Zhao Z, Chen Y, Cheng X, Huang L, Wen H, Xu Q, Zhou X, Zhang X, Chen J, Ni T. Zhao Z, et al. Sci Adv. 2023 Apr 5;9(14):eadf3264. doi: 10.1126/sciadv.adf3264. Epub 2023 Apr 5. Sci Adv. 2023. PMID: 37018400 Free PMC article.
Moreover, CRISPR-mediated epigenetic editing assays revealed that transcription of a noncoding RNA LRRK1-CAPT promoted LUSC cell proliferation, suggesting its oncogenic role. Our findings largely expand our understanding of cancer-associated transcription events, wh …
Moreover, CRISPR-mediated epigenetic editing assays revealed that transcription of a noncoding RNA LRRK1-CAPT promoted LUSC cell prol …
LINC00511 exacerbated T-cell acute lymphoblastic leukemia via miR-195-5p/LRRK1 axis.
Li S, Guo W, Geng H, Wang C, Yang S, Xu X. Li S, et al. Biosci Rep. 2020 May 29;40(5):BSR20193631. doi: 10.1042/BSR20193631. Biosci Rep. 2020. PMID: 32242897 Free PMC article.
Then, miR-195-5p was validated to bind with LINC00511. Hereafter, LRRK1 was testified to serve as a target gene of miR-195-5p. At last, rescue assays suggested that LRRK1 overexpression restored sh-LINC00511#1-mediated effects on cell proliferation and apoptosis. Al …
Then, miR-195-5p was validated to bind with LINC00511. Hereafter, LRRK1 was testified to serve as a target gene of miR-195-5p. At las …
Genome-Wide DNA Methylation Pattern of Cancer Stem Cells in Esophageal Cancer.
Yu X, Teng Y, Jiang X, Yuan H, Jiang W. Yu X, et al. Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033820983793. doi: 10.1177/1533033820983793. Technol Cancer Res Treat. 2020. PMID: 33357046 Free PMC article.
BACKGROUND: Cancer stem cells (CSCs) are considered the main cause of cancer recurrence and metastasis, and DNA methylation is involved in the maintenance of CSCs. ...Sphere-forming cells were collected from human primary esophageal cancer cells. SP cells and …
BACKGROUND: Cancer stem cells (CSCs) are considered the main cause of cancer recurrence and metastasis, and DNA methylation is …
Identification of Pan-Cancer Prognostic Biomarkers Through Integration of Multi-Omics Data.
Zhao N, Guo M, Wang K, Zhang C, Liu X. Zhao N, et al. Front Bioeng Biotechnol. 2020 Apr 2;8:268. doi: 10.3389/fbioe.2020.00268. eCollection 2020. Front Bioeng Biotechnol. 2020. PMID: 32300588 Free PMC article.
In this work, we integrated multi-omics data [DNA methylation (DM), gene expression (GE), somatic copy number alternation, and microRNA expression (ME)] and proposed a method to rank genes by desiring a "Score." Applying the method, cancer-specific prognostic biomarkers fo …
In this work, we integrated multi-omics data [DNA methylation (DM), gene expression (GE), somatic copy number alternation, and microRNA expr …
Broadening the phenotype of LRRK1 mutations - Features of malignant osteopetrosis and optic nerve atrophy with intrafamilial variable expressivity.
Chorin O, Chowers G, Agbariah R, Karklinsky S, Barel O, Bar-Joseph I, Reznik-Wolf H, Shamash J, Pode-Shakked B, Jacobson JM, Huna-Baron R, Redler Y, Tirosh I, Vivante A, Raas-Rothschild A. Chorin O, et al. Eur J Med Genet. 2022 Jan;65(1):104383. doi: 10.1016/j.ejmg.2021.104383. Epub 2021 Nov 16. Eur J Med Genet. 2022. PMID: 34798323
Additional features which have variably been reported include developmental delay, short stature, hypotonia and seizures. The disease is caused by pathogenic variants in the LRRK1 gene, and inherited in an autosomal recessive manner. We report three siblings (ages 14 years …
Additional features which have variably been reported include developmental delay, short stature, hypotonia and seizures. The disease is cau …
The emerging interrelation between ROCO and related kinases, intracellular Ca2+ signaling, and autophagy.
Kania E, Parys JB. Kania E, et al. Biochim Biophys Acta Mol Cell Res. 2019 Jul;1866(7):1054-1067. doi: 10.1016/j.bbamcr.2018.12.008. Epub 2018 Dec 21. Biochim Biophys Acta Mol Cell Res. 2019. PMID: 30582936 Free article. Review.
Further research will be needed for obtaining a full understanding of the role of these various kinases in autophagy and to assess their exact relation with intracellular Ca(2+) signaling as this would be helpful in the development of novel therapeutic strategies against neurodeg …
Further research will be needed for obtaining a full understanding of the role of these various kinases in autophagy and to assess their exa …
Driver and novel genes correlated with metastasis of non-small cell lung cancer: A comprehensive analysis.
Wu Y, Ni H, Yang D, Niu Y, Chen K, Xu J, Wang F, Tang S, Shi Y, Zhang H, Hu J, Xia D, Wu Y. Wu Y, et al. Pathol Res Pract. 2021 Aug;224:153551. doi: 10.1016/j.prp.2021.153551. Epub 2021 Jul 10. Pathol Res Pract. 2021. PMID: 34298439
Although mutations of genes are crucial events in tumorigenesis and development, the association between gene mutations and lung cancer metastasis is still largely unknown. The goal of this study is to identify driver and novel genes associated with non-small cell lung …
Although mutations of genes are crucial events in tumorigenesis and development, the association between gene mutations and lung cancer …
15 results