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Different impact of vitamin D on mitochondrial activity and morphology in normal and malignant keratinocytes, the role of genomic pathway.
Olszewska AM, Nowak JI, Król O, Flis D, Żmijewski MA. Olszewska AM, et al. Free Radic Biol Med. 2024 Jan;210:286-303. doi: 10.1016/j.freeradbiomed.2023.11.033. Epub 2023 Nov 30. Free Radic Biol Med. 2024. PMID: 38040270 Free article.
Deregulation of mitochondria activity is one of the hallmarks of cancerogenesis and an important target for cancer therapy. Therefore, we compared the impact of an active form of vitamin D(3) (1,25(OH)(2)D(3)) on mitochondrial morphology and bioenergetics in human squamous …
Deregulation of mitochondria activity is one of the hallmarks of cancerogenesis and an important target for cancer therapy. Therefore …
Identification of Genes That Modulate Susceptibility to Formaldehyde and Imatinib by Functional Genomic Screening in Human Haploid KBM7 Cells.
Shen H, McHale CM, Haider SI, Jung C, Zhang S, Smith MT, Zhang L. Shen H, et al. Toxicol Sci. 2016 May;151(1):10-22. doi: 10.1093/toxsci/kfw032. Epub 2016 Mar 22. Toxicol Sci. 2016. PMID: 27008852 Free PMC article.
Validation experiments conducted on KBM7 mutants lacking each of the 18 genes confirmed resistance of 6 FA mutants (CTC1, FCRLA, GOT1, LPR5, M1AP, and MAP2K5) and 1 imatinib-resistant mutant (LYRM9). Despite the improvements to the method, it remains technically challengin …
Validation experiments conducted on KBM7 mutants lacking each of the 18 genes confirmed resistance of 6 FA mutants (CTC1, FCRLA, GOT1, LPR5, …