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Clostridioides difficile infection damages colonic stem cells via TcdB, impairing epithelial repair and recovery from disease.
Mileto SJ, Jardé T, Childress KO, Jensen JL, Rogers AP, Kerr G, Hutton ML, Sheedlo MJ, Bloch SC, Shupe JA, Horvay K, Flores T, Engel R, Wilkins S, McMurrick PJ, Lacy DB, Abud HE, Lyras D. Mileto SJ, et al. Among authors: lacy db. Proc Natl Acad Sci U S A. 2020 Apr 7;117(14):8064-8073. doi: 10.1073/pnas.1915255117. Epub 2020 Mar 20. Proc Natl Acad Sci U S A. 2020. PMID: 32198200 Free PMC article.
Crystal structure of the Helicobacter pylori vacuolating toxin p55 domain.
Gangwer KA, Mushrush DJ, Stauff DL, Spiller B, McClain MS, Cover TL, Lacy DB. Gangwer KA, et al. Among authors: lacy db. Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16293-8. doi: 10.1073/pnas.0707447104. Epub 2007 Oct 2. Proc Natl Acad Sci U S A. 2007. PMID: 17911250 Free PMC article.
Molecular assembly of botulinum neurotoxin progenitor complexes.
Benefield DA, Dessain SK, Shine N, Ohi MD, Lacy DB. Benefield DA, et al. Among authors: lacy db. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5630-5. doi: 10.1073/pnas.1222139110. Epub 2013 Mar 18. Proc Natl Acad Sci U S A. 2013. PMID: 23509303 Free PMC article.
Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities.
Quesada-Gómez C, López-Ureña D, Chumbler N, Kroh HK, Castro-Peña C, Rodríguez C, Orozco-Aguilar J, González-Camacho S, Rucavado A, Guzmán-Verri C, Lawley TD, Lacy DB, Chaves-Olarte E. Quesada-Gómez C, et al. Among authors: lacy db. Infect Immun. 2016 Jan 11;84(3):856-65. doi: 10.1128/IAI.01291-15. Infect Immun. 2016. PMID: 26755157 Free PMC article.
202 results