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Targeting AAV vectors to the central nervous system by engineering capsid-receptor interactions that enable crossing of the blood-brain barrier.
Huang Q, Chen AT, Chan KY, Sorensen H, Barry AJ, Azari B, Zheng Q, Beddow T, Zhao B, Tobey IG, Moncada-Reid C, Eid FE, Walkey CJ, Ljungberg MC, Lagor WR, Heaney JD, Chan YA, Deverman BE. Huang Q, et al. Among authors: lagor wr. PLoS Biol. 2023 Jul 19;21(7):e3002112. doi: 10.1371/journal.pbio.3002112. eCollection 2023 Jul. PLoS Biol. 2023. PMID: 37467291 Free PMC article.
CaMKIIδ gene editing- A base hit for the heart.
Walkey CJ, Lagor WR. Walkey CJ, et al. Among authors: lagor wr. J Cardiovasc Aging. 2023;3(2):19. doi: 10.20517/jca.2023.11. Epub 2023 Mar 22. J Cardiovasc Aging. 2023. PMID: 37065676 Free PMC article. No abstract available.
In vivo expansion of gene-targeted hepatocytes through transient inhibition of an essential gene.
De Giorgi M, Park SH, Castoreno A, Cao M, Hurley A, Saxena L, Chuecos MA, Walkey CJ, Doerfler AM, Furgurson MN, Ljungberg MC, Patel KR, Hyde S, Chickering T, Lefebvre S, Wassarman K, Miller P, Qin J, Schlegel MK, Zlatev I, Li RG, Kim J, Martin JF, Bissig KD, Jadhav V, Bao G, Lagor WR. De Giorgi M, et al. Among authors: lagor wr. bioRxiv [Preprint]. 2023 Jul 29:2023.07.26.550728. doi: 10.1101/2023.07.26.550728. bioRxiv. 2023. PMID: 37546995 Free PMC article. Preprint.
Long-term efficacy and safety of cardiac genome editing for catecholaminergic polymorphic ventricular tachycardia.
Moore OM, Aguilar-Sanchez Y, Lahiri SK, Hulsurkar MM, Alberto Navarro-Garcia J, Word TA, Keefe JA, Barazi D, Munivez EM, Moore CT, Parthasarathy V, Davidson J, Lagor WR, Park SH, Bao G, Miyake CY, Wehrens XHT. Moore OM, et al. Among authors: lagor wr. J Cardiovasc Aging. 2024 Jan;4(1):8. doi: 10.20517/jca.2023.42. Epub 2024 Jan 4. J Cardiovasc Aging. 2024. PMID: 38464671
Speg interactions that regulate the stability of excitation-contraction coupling protein complexes in triads and dyads.
Lee CS, Jung SY, Yee RSZ, Agha NH, Hong J, Chang T, Babcock LW, Fleischman JD, Clayton B, Hanna AD, Ward CS, Lanza D, Hurley AE, Zhang P, Wehrens XHT, Lagor WR, Rodney GG, Hamilton SL. Lee CS, et al. Among authors: lagor wr. Commun Biol. 2023 Sep 14;6(1):942. doi: 10.1038/s42003-023-05330-y. Commun Biol. 2023. PMID: 37709832 Free PMC article.
High levels of lipoprotein(a) in transgenic mice exacerbate atherosclerosis and promote vulnerable plaque features in a sex-specific manner.
Assini JM, Clark JR, Youssef A, Xing C, Doerfler AM, Park SH, Saxena L, Yaseen AB, Børen J, Gros R, Bao G, Lagor WR, Boffa MB, Koschinsky ML. Assini JM, et al. Among authors: lagor wr. Atherosclerosis. 2023 Nov;384:117150. doi: 10.1016/j.atherosclerosis.2023.05.019. Epub 2023 May 30. Atherosclerosis. 2023. PMID: 37290980
Rescue of glutaric aciduria type I in mice by liver-directed therapies.
Barzi M, Johnson CG, Chen T, Rodriguiz RM, Hemmingsen M, Gonzalez TJ, Rosales A, Beasley J, Peck CK, Ma Y, Stiles AR, Wood TC, Maeso-Diaz R, Diehl AM, Young SP, Everitt JI, Wetsel WC, Lagor WR, Bissig-Choisat B, Asokan A, El-Gharbawy A, Bissig KD. Barzi M, et al. Among authors: lagor wr. Sci Transl Med. 2023 Apr 19;15(692):eadf4086. doi: 10.1126/scitranslmed.adf4086. Epub 2023 Apr 19. Sci Transl Med. 2023. PMID: 37075130 Free PMC article.
In vivo editing of the pan-endothelium by immunity evading simian adenoviral vector.
Lorincz R, Alvarez AB, Walkey CJ, Mendonça SA, Lu ZH, Martinez AE, Ljungberg C, Heaney JD, Lagor WR, Curiel DT. Lorincz R, et al. Among authors: lagor wr. Biomed Pharmacother. 2023 Feb;158:114189. doi: 10.1016/j.biopha.2022.114189. Epub 2022 Dec 30. Biomed Pharmacother. 2023. PMID: 36587560 Free article.
63 results