SparseSignatures: An R package using LASSO-regularized non-negative matrix factorization to identify mutational signatures from human tumor samples.
Mella L, Lal A, Angaroni F, Maspero D, Piazza R, Sidow A, Antoniotti M, Graudenzi A, Ramazzotti D.
Mella L, et al. Among authors: lal a.
STAR Protoc. 2022 Sep 16;3(3):101513. doi: 10.1016/j.xpro.2022.101513. Epub 2022 Jul 1.
STAR Protoc. 2022.
PMID: 35779264
Free PMC article.
We outline the features of the R package SparseSignatures and its application to determine the signatures contributing to mutation profiles of tumor samples. We describe installation details and illustrate a step-by-step approach to (1) prepare the data for signature analy …
We outline the features of the R package SparseSignatures and its application to determine the signatures contributing to mutation profiles …