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Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms.
Nat Commun. 2020 May 8;11(1):2319. doi: 10.1038/s41467-020-16128-5.
Nat Commun. 2020.
PMID: 32385234
Free PMC article.
The SH2 domain of Abl kinases regulates kinase autophosphorylation by controlling activation loop accessibility.
Lamontanara AJ, Georgeon S, Tria G, Svergun DI, Hantschel O.
Lamontanara AJ, et al.
Nat Commun. 2014 Nov 17;5:5470. doi: 10.1038/ncomms6470.
Nat Commun. 2014.
PMID: 25399951
Free article.
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Allosteric Inhibition of Bcr-Abl Kinase by High Affinity Monobody Inhibitors Directed to the Src Homology 2 (SH2)-Kinase Interface.
Wojcik J, Lamontanara AJ, Grabe G, Koide A, Akin L, Gerig B, Hantschel O, Koide S.
Wojcik J, et al. Among authors: lamontanara aj.
J Biol Chem. 2016 Apr 15;291(16):8836-47. doi: 10.1074/jbc.M115.707901. Epub 2016 Feb 24.
J Biol Chem. 2016.
PMID: 26912659
Free PMC article.
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Mechanisms of resistance to BCR-ABL and other kinase inhibitors.
Lamontanara AJ, Gencer EB, Kuzyk O, Hantschel O.
Lamontanara AJ, et al.
Biochim Biophys Acta. 2013 Jul;1834(7):1449-59. doi: 10.1016/j.bbapap.2012.12.009. Epub 2012 Dec 28.
Biochim Biophys Acta. 2013.
PMID: 23277196
Review.
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ATP Site Ligands Determine the Assembly State of the Abelson Kinase Regulatory Core via the Activation Loop Conformation.
Sonti R, Hertel-Hering I, Lamontanara AJ, Hantschel O, Grzesiek S.
Sonti R, et al. Among authors: lamontanara aj.
J Am Chem Soc. 2018 Feb 7;140(5):1863-1869. doi: 10.1021/jacs.7b12430. Epub 2018 Jan 29.
J Am Chem Soc. 2018.
PMID: 29319304
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c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease.
Mahul-Mellier AL, Fauvet B, Gysbers A, Dikiy I, Oueslati A, Georgeon S, Lamontanara AJ, Bisquertt A, Eliezer D, Masliah E, Halliday G, Hantschel O, Lashuel HA.
Mahul-Mellier AL, et al. Among authors: lamontanara aj.
Hum Mol Genet. 2014 Jun 1;23(11):2858-79. doi: 10.1093/hmg/ddt674. Epub 2014 Jan 9.
Hum Mol Genet. 2014.
PMID: 24412932
Free PMC article.
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