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Year Number of Results
1985 1
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1994 10
1995 9
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Page 1
LAMP2 regulates autophagy in the thymic epithelium and thymic stroma-dependent CD4 T cell development.
Rodrigues PM, Sousa LG, Perrod C, Maceiras AR, Ferreirinha P, Pombinho R, Romera-Cárdenas G, Gomez-Lazaro M, Senkara M, Pistolic J, Cabanes D, Klein L, Saftig P, Alves NL. Rodrigues PM, et al. Autophagy. 2023 Feb;19(2):426-439. doi: 10.1080/15548627.2022.2074105. Epub 2022 May 19. Autophagy. 2023. PMID: 35535798 Free PMC article.
We showed that LAMP2 is highly expressed in cTECs. Notably, genetic inactivation of Lamp2 in thymic stromal cells specifically impaired the development of CD4 T cells that completed positive selection, without misdirecting MHC II-restricted cells into the CD8 lineag …
We showed that LAMP2 is highly expressed in cTECs. Notably, genetic inactivation of Lamp2 in thymic stromal cells specifically …
Danon Disease: Entire LAMP2 Gene Deletion with Unusual Clinical Presentation-Case Report and Review of the Literature.
Shalata A, Bar-Shai M, Hadid Y, Mahroum M, Mintz H, Shalata ZE, Radzishevsky E, Genizi J, Lorber A, Ben-Yosef T, Yaniv L. Shalata A, et al. Genes (Basel). 2023 Jul 27;14(8):1539. doi: 10.3390/genes14081539. Genes (Basel). 2023. PMID: 37628591 Free PMC article. Review.
It is caused by defects in the lysosome-associated membrane protein-2 (LAMP2) gene. Numerous different mutations in the LAMP2 protein have been described. ...Genetic testing revealed an Xq24 microdeletion encompassing the entire LAMP2 gene. Relevant literatur …
It is caused by defects in the lysosome-associated membrane protein-2 (LAMP2) gene. Numerous different mutations in the LAMP2 …
LAMP2 Cardiomyopathy: Consequences of Impaired Autophagy in the Heart.
Alcalai R, Arad M, Wakimoto H, Yadin D, Gorham J, Wang L, Burns E, Maron BJ, Roberts WC, Konno T, Conner DA, Perez-Atayde AR, Seidman JG, Seidman CE. Alcalai R, et al. J Am Heart Assoc. 2021 Sep 7;10(17):e018829. doi: 10.1161/JAHA.120.018829. Epub 2021 Aug 28. J Am Heart Assoc. 2021. PMID: 34459252 Free PMC article.
We introduced an in-frame LAMP2 gene exon 6 deletion mutation (denoted L2(delta6)) causing human cardiomyopathy, into mouse LAMP2 gene, to elucidate its consequences on cardiomyocyte biology. This mutation results in in-frame deletion of 41 amino acids, compatible w …
We introduced an in-frame LAMP2 gene exon 6 deletion mutation (denoted L2(delta6)) causing human cardiomyopathy, into mouse LAMP2 …
Thyroid hormone upregulates LAMP2 expression and lysosome activity.
Tseng YH, Chang CC, Lin KH. Tseng YH, et al. Biochem Biophys Res Commun. 2023 Jun 25;662:66-75. doi: 10.1016/j.bbrc.2023.04.061. Epub 2023 Apr 20. Biochem Biophys Res Commun. 2023. PMID: 37099812
In a murine model, LAMP2 protein was specifically induced in mice with hyperthyroidism. ...In the presence of the lysosomal autophagy inhibitors bafilomycin A1, chloroquine and ammonium chloride, we observed substantial accumulation of LAMP2 but not LAMP1 protein. T …
In a murine model, LAMP2 protein was specifically induced in mice with hyperthyroidism. ...In the presence of the lysosomal autophagy …
LAMP2 deficiency attenuates the neurodegeneration markers induced by HSV-1 infection.
Kristen H, Sastre I, Aljama S, Fuentes M, Recuero M, Frank-García A, Martin A, Sanchez-Juan P, Lage C, Bullido MJ, Aldudo J. Kristen H, et al. Neurochem Int. 2021 Jun;146:105032. doi: 10.1016/j.neuint.2021.105032. Epub 2021 Mar 27. Neurochem Int. 2021. PMID: 33781848 Free article.
LAMP2 deficiency led to a significant reduction of viral DNA replication and formation of infectious particles. In addition, tau hyperphosphorylation and inhibition of Abeta secretion induced by the virus were attenuated by the absence of LAMP2. Finally, genetic ass …
LAMP2 deficiency led to a significant reduction of viral DNA replication and formation of infectious particles. In addition, tau hype …
LAMP2A, LAMP2B and LAMP2C: similar structures, divergent roles.
Qiao L, Hu J, Qiu X, Wang C, Peng J, Zhang C, Zhang M, Lu H, Chen W. Qiao L, et al. Autophagy. 2023 Nov;19(11):2837-2852. doi: 10.1080/15548627.2023.2235196. Epub 2023 Jul 21. Autophagy. 2023. PMID: 37469132 Free PMC article. Review.
LAMP2 (lysosomal associated membrane protein 2) is one of the major protein components of the lysosomal membrane. There currently exist three LAMP2 isoforms, LAMP2A, LAMP2B and LAMP2C, and they vary in distribution and function. ...
LAMP2 (lysosomal associated membrane protein 2) is one of the major protein components of the lysosomal membrane. There currently exi …
LAMP2 expression dictates azacytidine response and prognosis in MDS/AML.
Dubois A, Furstoss N, Calleja A, Zerhouni M, Cluzeau T, Savy C, Marchetti S, Hamouda MA, Boulakirba S, Orange F, Lacas-Gervais S, Karsenti JM, Mounier N, Tamburini J, Puissant A, Luciano F, Jacquel A, Auberger P, Robert G. Dubois A, et al. Leukemia. 2019 Jun;33(6):1501-1513. doi: 10.1038/s41375-018-0336-1. Epub 2019 Jan 3. Leukemia. 2019. PMID: 30607021 Retracted.
Accordingly, gain of function of LAMP2 in deficient cells or loss of function in LAMP2-expressing cells rendered them sensitive or resistant to Aza, respectively. ...We propose that CD34(+)/LAMP2(Low) patients at diagnosis or who become CD34(+)/LAMP2(L …
Accordingly, gain of function of LAMP2 in deficient cells or loss of function in LAMP2-expressing cells rendered them sensitiv …
The CREG1-FBXO27-LAMP2 axis alleviates diabetic cardiomyopathy by promoting autophagy in cardiomyocytes.
Liu D, Xing R, Zhang Q, Tian X, Qi Y, Song H, Liu Y, Yu H, Zhang X, Jing Q, Yan C, Han Y. Liu D, et al. Exp Mol Med. 2023 Sep;55(9):2025-2038. doi: 10.1038/s12276-023-01081-2. Epub 2023 Sep 1. Exp Mol Med. 2023. PMID: 37658156 Free PMC article.
CREG1 overexpression inhibited cardiomyocyte hypertrophy and improved autophagy. LAMP2 overexpression reversed the effect of CREG1 knockdown on palmitate-induced inhibition of cardiomyocyte autophagy. CREG1 inhibited LAMP2 protein degradation by inhibiting the prote …
CREG1 overexpression inhibited cardiomyocyte hypertrophy and improved autophagy. LAMP2 overexpression reversed the effect of CREG1 kn …
Cholesterol Handling in Lysosomes and Beyond.
Meng Y, Heybrock S, Neculai D, Saftig P. Meng Y, et al. Trends Cell Biol. 2020 Jun;30(6):452-466. doi: 10.1016/j.tcb.2020.02.007. Epub 2020 Mar 23. Trends Cell Biol. 2020. PMID: 32413315 Review.
LAMP2 as a Biomarker Related to Prognosis and Immune Infiltration in Esophageal Cancer and Other Cancers: A Comprehensive Pan-Cancer Analysis.
Liu SP, Li XM, Liu DM, Xie SH, Zhang SB, Li Y, Xie ZF. Liu SP, et al. Front Oncol. 2022 Apr 21;12:884448. doi: 10.3389/fonc.2022.884448. eCollection 2022. Front Oncol. 2022. PMID: 35530327 Free PMC article.
We also obtained the differentially expressed genes between the high LAMP2 expression and low LAMP2 expression groups in ESCA and performed a functional enrichment analysis of the 250 linked genes most positively related to LAMP2 expression. Moreover, we perf …
We also obtained the differentially expressed genes between the high LAMP2 expression and low LAMP2 expression groups in ESCA …
1,503 results