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Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans.
De la Torre R, De Sola S, Pons M, Duchon A, de Lagran MM, Farré M, Fitó M, Benejam B, Langohr K, Rodriguez J, Pujadas M, Bizot JC, Cuenca A, Janel N, Catuara S, Covas MI, Blehaut H, Herault Y, Delabar JM, Dierssen M. De la Torre R, et al. Among authors: langohr k. Mol Nutr Food Res. 2014 Feb;58(2):278-88. doi: 10.1002/mnfr.201300325. Epub 2013 Sep 14. Mol Nutr Food Res. 2014. PMID: 24039182 Clinical Trial.
Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial.
de la Torre R, de Sola S, Hernandez G, Farré M, Pujol J, Rodriguez J, Espadaler JM, Langohr K, Cuenca-Royo A, Principe A, Xicota L, Janel N, Catuara-Solarz S, Sanchez-Benavides G, Bléhaut H, Dueñas-Espín I, Del Hoyo L, Benejam B, Blanco-Hinojo L, Videla S, Fitó M, Delabar JM, Dierssen M; TESDAD study group. de la Torre R, et al. Among authors: langohr k. Lancet Neurol. 2016 Jul;15(8):801-810. doi: 10.1016/S1474-4422(16)30034-5. Lancet Neurol. 2016. PMID: 27302362 Clinical Trial.
A phase 1, randomized double-blind, placebo controlled trial to evaluate safety and efficacy of epigallocatechin-3-gallate and cognitive training in adults with Fragile X syndrome.
de la Torre R, de Sola S, Farré M, Xicota L, Cuenca-Royo A, Rodriguez J, León A, Langohr K, Gomis-González M, Hernandez G, Esteba S, Del Hoyo L, Sánchez-Gutiérrez J, Cortés MJ, Ozaita A, Espadaler JM, Novell R, Martínez-Leal R, Milá M, Dierssen M; TESXF Study Group. de la Torre R, et al. Among authors: langohr k. Clin Nutr. 2020 Feb;39(2):378-387. doi: 10.1016/j.clnu.2019.02.028. Epub 2019 Mar 25. Clin Nutr. 2020. PMID: 30962103 Clinical Trial.
Ethanol induces hydroxytyrosol formation in humans.
Pérez-Mañá C, Farré M, Pujadas M, Mustata C, Menoyo E, Pastor A, Langohr K, de la Torre R. Pérez-Mañá C, et al. Among authors: langohr k. Pharmacol Res. 2015 May-Jun;95-96:27-33. doi: 10.1016/j.phrs.2015.02.008. Epub 2015 Mar 20. Pharmacol Res. 2015. PMID: 25801942 Clinical Trial.
A new cognitive evaluation battery for Down syndrome and its relevance for clinical trials.
de Sola S, de la Torre R, Sánchez-Benavides G, Benejam B, Cuenca-Royo A, Del Hoyo L, Rodríguez J, Catuara-Solarz S, Sanchez-Gutierrez J, Dueñas-Espin I, Hernandez G, Peña-Casanova J, Langohr K, Videla S, Blehaut H, Farre M, Dierssen M; TESDAD Study Group. de Sola S, et al. Among authors: langohr k. Front Psychol. 2015 Jun 4;6:708. doi: 10.3389/fpsyg.2015.00708. eCollection 2015. Front Psychol. 2015. PMID: 26089807 Free PMC article.
Combined Treatment With Environmental Enrichment and (-)-Epigallocatechin-3-Gallate Ameliorates Learning Deficits and Hippocampal Alterations in a Mouse Model of Down Syndrome.
Catuara-Solarz S, Espinosa-Carrasco J, Erb I, Langohr K, Gonzalez JR, Notredame C, Dierssen M. Catuara-Solarz S, et al. Among authors: langohr k. eNeuro. 2016 Nov 8;3(5):ENEURO.0103-16.2016. doi: 10.1523/ENEURO.0103-16.2016. eCollection 2016 Sep-Oct. eNeuro. 2016. PMID: 27844057 Free PMC article.
Semantic Verbal Fluency Pattern, Dementia Rating Scores and Adaptive Behavior Correlate With Plasma Aβ42 Concentrations in Down Syndrome Young Adults.
Hoyo LD, Xicota L, Sánchez-Benavides G, Cuenca-Royo A, de Sola S, Langohr K, Fagundo AB, Farré M, Dierssen M, de la Torre R. Hoyo LD, et al. Among authors: langohr k. Front Behav Neurosci. 2015 Nov 18;9:301. doi: 10.3389/fnbeh.2015.00301. eCollection 2015. Front Behav Neurosci. 2015. PMID: 26635555 Free PMC article.
94 results