Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 3
2004 2
2005 5
2006 3
2007 4
2008 3
2009 3
2010 11
2011 13
2012 16
2013 7
2014 11
2015 21
2016 10
2017 12
2018 16
2019 16
2020 15
2021 11
2022 9
2023 15
2024 6

Text availability

Article attribute

Article type

Publication date

Search Results

185 results

Results by year

Filters applied: . Clear all
Page 1
Downregulation of LAPTM4B Contributes to the Impairment of the Autophagic Flux via Unopposed Activation of mTORC1 Signaling During Myocardial Ischemia/Reperfusion Injury.
Gu S, Tan J, Li Q, Liu S, Ma J, Zheng Y, Liu J, Bi W, Sha P, Li X, Wei M, Cao N, Yang HT. Gu S, et al. Circ Res. 2020 Sep 11;127(7):e148-e165. doi: 10.1161/CIRCRESAHA.119.316388. Epub 2020 Jul 22. Circ Res. 2020. PMID: 32693673
During myocardial reperfusion, LAPTM4B-knockout (LAPTM4B(-/-)) mice had a significantly increased infarct size and lactate dehydrogenase release, whereas adenovirus-mediated LAPTM4B-overexpression was cardioprotective. ...Conversely, LAPTM4B-overexpres …
During myocardial reperfusion, LAPTM4B-knockout (LAPTM4B(-/-)) mice had a significantly increased infarct size and lactate deh …
LAPTM4B: an oncogene in various solid tumors and its functions.
Meng Y, Wang L, Chen D, Chang Y, Zhang M, Xu JJ, Zhou R, Zhang QY. Meng Y, et al. Oncogene. 2016 Dec 15;35(50):6359-6365. doi: 10.1038/onc.2016.189. Epub 2016 May 23. Oncogene. 2016. PMID: 27212036 Free PMC article. Review.
LAPTM4B-35 protein was found to be highly expressed in various solid tumors and could be a poor prognosis marker. The functions of LAPTM4B in solid tumors were also explored. It is suggested that LAPTM4B could promote the proliferation of tumor cells, boost i …
LAPTM4B-35 protein was found to be highly expressed in various solid tumors and could be a poor prognosis marker. The functions of …
Role and mechanism of action of LAPTM4B in EGFR-mediated autophagy.
Ji X, Ma H, Du Y. Ji X, et al. Oncol Lett. 2022 Apr;23(4):109. doi: 10.3892/ol.2022.13229. Epub 2022 Feb 7. Oncol Lett. 2022. PMID: 35242237 Free PMC article. Review.
LAPTM4B knockdown inhibits autophagosome maturation in the context of metabolic stress. ...Thus, LAPTM4B may be associated with autophagy through EGFR signaling. The present review proposed that LAPTM4B participates in regulating autophagy through the EGFR pa …
LAPTM4B knockdown inhibits autophagosome maturation in the context of metabolic stress. ...Thus, LAPTM4B may be associated wit …
LAPTM4B promotes the progression of nasopharyngeal cancer.
Su Q, Luo H, Zhang M, Gao L, Zhao F. Su Q, et al. Bosn J Basic Med Sci. 2021 Jun 1;21(3):305-312. doi: 10.17305/bjbms.2020.4738. Bosn J Basic Med Sci. 2021. PMID: 32651973 Free PMC article.
Furthermore, we inhibited the expression of LAPTM4B in NPC cell lines and examined the effects of LAPTM4B on NPC cell proliferation, migration, and invasion. ...NPC patients with high LAPTM4B expression had a worse prognosis. LAPTM4B knockdown inhibite …
Furthermore, we inhibited the expression of LAPTM4B in NPC cell lines and examined the effects of LAPTM4B on NPC cell prolifer …
LAPTM4B promotes AML progression through regulating RPS9/STAT3 axis.
Huang Y, Peng M, Qin H, Li Y, Pei L, Liu X, Zhao X. Huang Y, et al. Cell Signal. 2023 Jun;106:110623. doi: 10.1016/j.cellsig.2023.110623. Epub 2023 Feb 8. Cell Signal. 2023. PMID: 36758682 Free article.
Here, we found that lysosome-associated protein transmembrane 4 beta (LAPTM4B) was frequently upregulated in AML, and high LAPTM4B was associated with poor outcome. ...Our findings indicate for the first time that LAPTM4B contributes to leukemia progression i …
Here, we found that lysosome-associated protein transmembrane 4 beta (LAPTM4B) was frequently upregulated in AML, and high LAPTM4B …
LAPTM4B-YAP loop feedback amplification enhances the stemness of hepatocellular carcinoma.
Liao J, Wang J, Xu Y, Wu Y, Wang M, Zhao Q, Tan X, Meng Y, Wei L, Huang A. Liao J, et al. iScience. 2023 Apr 27;26(6):106754. doi: 10.1016/j.isci.2023.106754. eCollection 2023 Jun 16. iScience. 2023. PMID: 37213231 Free PMC article.
In this study, we identified that lysosome-associated protein transmembrane-4beta (LAPTM4B) was significantly overexpressed in stem-like tumor cell populations with multidirectional differentiation potential at the single cell level, and verified that LAPTM4B was cl …
In this study, we identified that lysosome-associated protein transmembrane-4beta (LAPTM4B) was significantly overexpressed in stem-l …
LAPTM4B promotes the progression of bladder cancer by stimulating cell proliferation and invasion.
Yin Y, Fan Y, Yu G, Du Y. Yin Y, et al. Oncol Lett. 2021 Nov;22(5):765. doi: 10.3892/ol.2021.13026. Epub 2021 Sep 8. Oncol Lett. 2021. PMID: 34589144 Free PMC article.
Immunohistochemistry was performed to detect the protein expression level of LAPTM4B in bladder cancer tissues and short hairpin RNAs targeting LAPTM4B were transfected into bladder cancer cells to knockdown its expression. ...In addition, tumor growth assays were p …
Immunohistochemistry was performed to detect the protein expression level of LAPTM4B in bladder cancer tissues and short hairpin RNAs …
LAPTM4B controls the sphingolipid and ether lipid signature of small extracellular vesicles.
Dichlberger A, Zhou K, Bäck N, Nyholm T, Backman A, Mattjus P, Ikonen E, Blom T. Dichlberger A, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Feb;1866(2):158855. doi: 10.1016/j.bbalip.2020.158855. Epub 2020 Nov 10. Biochim Biophys Acta Mol Cell Biol Lipids. 2021. PMID: 33181324
Unbiased lipidomic analysis reveals a strong enrichment of glycosphingolipids in sEVs secreted from LAPTM4B knockout cells and from cells expressing a SLim-deficient LAPTM4B mutant. ...These results identify LAPTM4B as a determinant of the glycosphingolipid p …
Unbiased lipidomic analysis reveals a strong enrichment of glycosphingolipids in sEVs secreted from LAPTM4B knockout cells and from c …
LAPTM4B is a novel diagnostic and prognostic marker for lung adenocarcinoma and associated with mutant EGFR.
Wang L, Meng Y, Zhang QY. Wang L, et al. BMC Cancer. 2019 Apr 2;19(1):293. doi: 10.1186/s12885-019-5506-7. BMC Cancer. 2019. PMID: 30940109 Free PMC article.
RESULTS: We found LAPTM4B was upregulated in LAC tissues and high LAPTM4B expression was significantly correlated with poor prognosis. ...Overexpression of LAPTM4B promoted, while silencing of LAPTM4B inhibited proliferation, invasion and migration of …
RESULTS: We found LAPTM4B was upregulated in LAC tissues and high LAPTM4B expression was significantly correlated with poor pr …
Serum LAPTM4B as a Potential Diagnostic and Prognostic Biomarker for Breast Cancer.
Wang L, Wang Y, Zhang Q. Wang L, et al. Biomed Res Int. 2022 Nov 30;2022:6786351. doi: 10.1155/2022/6786351. eCollection 2022. Biomed Res Int. 2022. PMID: 36506911 Free PMC article.
The present study is aimed at understanding the clinical significance of serum LAPTM4B in breast cancer (BC). METHODS: Serum LAPTM4B level was evaluated in 426 BC patients, 40 benign breast disease, and 80 healthy controls by ELISA. ...CONCLUSION: Our results propos …
The present study is aimed at understanding the clinical significance of serum LAPTM4B in breast cancer (BC). METHODS: Serum LAPTM …
185 results