Large TH - Search Results

1

SEP-363856, a Novel Psychotropic Agent with a Unique, Non-D₂ Receptor Mechanism of Action.

Dedic N, Jones PG, Hopkins SC, Lew R, Shao L, Campbell JE, Spear KL, Large TH, Campbell UC, Hanania T, Leahy E, Koblan KS. Dedic N, et al. Among authors: large th. J Pharmacol Exp Ther. 2019 Oct;371(1):1-14. doi: 10.1124/jpet.119.260281. Epub 2019 Aug 1. J Pharmacol Exp Ther. 2019. PMID: 31371483

2

Pharmacodynamic effects of a D-amino acid oxidase inhibitor indicate a spinal site of action in rat models of neuropathic pain.

Hopkins SC, Zhao FY, Bowen CA, Fang X, Wei H, Heffernan ML, Spear KL, Spanswick DC, Varney MA, Large TH. Hopkins SC, et al. Among authors: large th. J Pharmacol Exp Ther. 2013 Jun;345(3):502-11. doi: 10.1124/jpet.113.204016. Epub 2013 Mar 21. J Pharmacol Exp Ther. 2013. PMID: 23520265 Free article.

3

Effects of D-amino acid oxidase inhibition on memory performance and long-term potentiation in vivo.

Hopkins SC, Campbell UC, Heffernan ML, Spear KL, Jeggo RD, Spanswick DC, Varney MA, Large TH. Hopkins SC, et al. Among authors: large th. Pharmacol Res Perspect. 2013 Oct;1(1):e00007. doi: 10.1002/prp2.7. Epub 2013 Oct 1. Pharmacol Res Perspect. 2013. PMID: 25505561 Free PMC article.

4

Structural, kinetic, and pharmacodynamic mechanisms of D-amino acid oxidase inhibition by small molecules.

Hopkins SC, Heffernan ML, Saraswat LD, Bowen CA, Melnick L, Hardy LW, Orsini MA, Allen MS, Koch P, Spear KL, Foglesong RJ, Soukri M, Chytil M, Fang QK, Jones SW, Varney MA, Panatier A, Oliet SH, Pollegioni L, Piubelli L, Molla G, Nardini M, Large TH. Hopkins SC, et al. Among authors: large th. J Med Chem. 2013 May 9;56(9):3710-24. doi: 10.1021/jm4002583. Epub 2013 Apr 30. J Med Chem. 2013. PMID: 23631755

5

Novel human D-amino acid oxidase inhibitors stabilize an active-site lid-open conformation.

Terry-Lorenzo RT, Chun LE, Brown SP, Heffernan ML, Fang QK, Orsini MA, Pollegioni L, Hardy LW, Spear KL, Large TH. Terry-Lorenzo RT, et al. Among authors: large th. Biosci Rep. 2014 Aug 11;34(4):e00133. doi: 10.1042/BSR20140071. Biosci Rep. 2014. PMID: 25001371 Free PMC article.

6

Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2- trifluoroethylsulfonyl)pyrid-3-ylmethylamine.

Johnson MP, Baez M, Jagdmann GE Jr, Britton TC, Large TH, Callagaro DO, Tizzano JP, Monn JA, Schoepp DD. Johnson MP, et al. Among authors: large th. J Med Chem. 2003 Jul 17;46(15):3189-92. doi: 10.1021/jm034015u. J Med Chem. 2003. PMID: 12852748

7

Allosteric modulators of metabotropic glutamate receptors: lessons learnt from mGlu1, mGlu2 and mGlu5 potentiators and antagonists.

Johnson MP, Nisenbaum ES, Large TH, Emkey R, Baez M, Kingston AE. Johnson MP, et al. Among authors: large th. Biochem Soc Trans. 2004 Nov;32(Pt 5):881-7. doi: 10.1042/BST0320881. Biochem Soc Trans. 2004. PMID: 15494040 Review.

8

Pharmacological characterization of glutamatergic agonists and antagonists at recombinant human homomeric and heteromeric kainate receptors in vitro.

Alt A, Weiss B, Ogden AM, Knauss JL, Oler J, Ho K, Large TH, Bleakman D. Alt A, et al. Among authors: large th. Neuropharmacology. 2004 May;46(6):793-806. doi: 10.1016/j.neuropharm.2003.11.026. Neuropharmacology. 2004. PMID: 15033339

9

Test-retest reliability of evoked heat stimulation BOLD fMRI.

Upadhyay J, Lemme J, Anderson J, Bleakman D, Large T, Evelhoch JL, Hargreaves R, Borsook D, Becerra L. Upadhyay J, et al. J Neurosci Methods. 2015 Sep 30;253:38-46. doi: 10.1016/j.jneumeth.2015.06.001. Epub 2015 Jun 10. J Neurosci Methods. 2015. PMID: 26072245

10

Niacin mediates lipolysis in adipose tissue through its G-protein coupled receptor HM74A.

Zhang Y, Schmidt RJ, Foxworthy P, Emkey R, Oler JK, Large TH, Wang H, Su EW, Mosior MK, Eacho PI, Cao G. Zhang Y, et al. Among authors: large th. Biochem Biophys Res Commun. 2005 Aug 26;334(2):729-32. doi: 10.1016/j.bbrc.2005.06.141. Biochem Biophys Res Commun. 2005. PMID: 16018973

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