Laufer S - Search Results

1

Imidazoquinolines with improved pharmacokinetic properties induce a high IFNα to TNFα ratio in vitro and in vivo.

Keppler M, Straß S, Geiger S, Fischer T, Späth N, Weinstein T, Schwamborn A, Guezguez J, Guse JH, Laufer S, Burnet M. Keppler M, et al. Among authors: laufer s. Front Immunol. 2023 Jun 20;14:1168252. doi: 10.3389/fimmu.2023.1168252. eCollection 2023. Front Immunol. 2023. PMID: 37409123 Free PMC article.

2

HDAC specificity and kinase off-targeting by purine-benzohydroxamate anti-hematological tumor agents.

Waitman KB, de Almeida LC, Primi MC, Carlos JAEG, Ruiz C, Kronenberger T, Laufer S, Goettert MI, Poso A, Vassiliades SV, de Souza VAM, Toledo MFZJ, Hassimotto NMA, Cameron MD, Bannister TD, Costa-Lotufo LV, Machado-Neto JA, Tavares MT, Parise-Filho R. Waitman KB, et al. Among authors: laufer s. Eur J Med Chem. 2024 Jan 5;263:115935. doi: 10.1016/j.ejmech.2023.115935. Epub 2023 Nov 10. Eur J Med Chem. 2024. PMID: 37989057

3

Structural elements that enable specificity for mutant EGFR kinase domains with next-generation small-molecule inhibitors.

Damghani T, Wittlinger F, Beyett TS, Eck MJ, Laufer SA, Heppner DE. Damghani T, et al. Among authors: laufer sa. Methods Enzymol. 2023;685:171-198. doi: 10.1016/bs.mie.2023.03.013. Epub 2023 Apr 27. Methods Enzymol. 2023. PMID: 37245901 Free PMC article.

4

Small-molecule inhibition of MAP2K4 is synergistic with RAS inhibitors in KRAS-mutant cancers.

Jansen RA, Mainardi S, Dias MH, Bosma A, van Dijk E, Selig R, Albrecht W, Laufer SA, Zender L, Bernards R. Jansen RA, et al. Among authors: laufer sa. Proc Natl Acad Sci U S A. 2024 Feb 27;121(9):e2319492121. doi: 10.1073/pnas.2319492121. Epub 2024 Feb 20. Proc Natl Acad Sci U S A. 2024. PMID: 38377196

5

COVID-19 therapeutics: Small-molecule drug development targeting SARS-CoV-2 main protease.

Kronenberger T, Laufer SA, Pillaiyar T. Kronenberger T, et al. Drug Discov Today. 2023 Jun;28(6):103579. doi: 10.1016/j.drudis.2023.103579. Epub 2023 Apr 5. Drug Discov Today. 2023. PMID: 37028502 Free PMC article. Review.

6

Direct 3D printed biocompatible microfluidics: assessment of human mesenchymal stem cell differentiation and cytotoxic drug screening in a dynamic culture system.

Riester O, Laufer S, Deigner HP. Riester O, et al. Among authors: laufer s. J Nanobiotechnology. 2022 Dec 27;20(1):540. doi: 10.1186/s12951-022-01737-7. J Nanobiotechnology. 2022. PMID: 36575530 Free PMC article.

7

Targeting Lewy body dementia with neflamapimod-rasagiline hybrids.

Albertini C, Petralla S, Massenzio F, Monti B, Rizzardi N, Bergamini C, Uliassi E, Borges F, Chavarria D, Fricker G, Goettert M, Kronenberger T, Gehringer M, Laufer S, Bolognesi ML. Albertini C, et al. Among authors: laufer s. Arch Pharm (Weinheim). 2024 Feb 27:e2300525. doi: 10.1002/ardp.202300525. Online ahead of print. Arch Pharm (Weinheim). 2024. PMID: 38412454

8

Ready-to-use nanopore platform for label-free small molecule quantification: Ethanolamine as first example.

Quint I, Simantzik J, Kaiser L, Laufer S, Csuk R, Smith D, Kohl M, Deigner HP. Quint I, et al. Among authors: laufer s. Nanomedicine. 2024 Jan;55:102724. doi: 10.1016/j.nano.2023.102724. Epub 2023 Nov 23. Nanomedicine. 2024. PMID: 38007066

9

First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure.

Zwirner S, Abu Rmilah AA, Klotz S, Pfaffenroth B, Kloevekorn P, Moschopoulou AA, Schuette S, Haag M, Selig R, Li K, Zhou W, Nelson E, Poso A, Chen H, Amiot B, Jia Y, Minshew A, Michalak G, Cui W, Rist E, Longerich T, Jung B, Felgendreff P, Trompak O, Premsrirut PK, Gries K, Muerdter TE, Heinkele G, Wuestefeld T, Shapiro D, Weissbach M, Koenigsrainer A, Sipos B, Ab E, Zacarias MO, Theisgen S, Gruenheit N, Biskup S, Schwab M, Albrecht W, Laufer S, Nyberg S, Zender L. Zwirner S, et al. Among authors: laufer s. Cell. 2024 Mar 28;187(7):1666-1684.e26. doi: 10.1016/j.cell.2024.02.023. Epub 2024 Mar 14. Cell. 2024. PMID: 38490194 Free PMC article. Clinical Trial.

10

Synergy of R-(-)carvone and cyclohexenone-based carbasugar precursors with antibiotics to enhance antibiotic potency and inhibit biofilm formation.

Riester O, Burkhardtsmaier P, Gurung Y, Laufer S, Deigner HP, Schmidt MS. Riester O, et al. Among authors: laufer s. Sci Rep. 2022 Oct 26;12(1):18019. doi: 10.1038/s41598-022-22807-8. Sci Rep. 2022. PMID: 36289389 Free PMC article.

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