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Pacritinib Combined with Sirolimus and Low-Dose Tacrolimus for GVHD Prevention after Allogeneic Hematopoietic Cell Transplantation: Preclinical and Phase I Trial Results.
Pidala J, Walton K, Elmariah H, Kim J, Mishra A, Bejanyan N, Nishihori T, Khimani F, Perez L, Faramand RG, Davila ML, Nieder ML, Sagatys EM, Holtan SG, Lawrence NJ, Lawrence HR, Blazar BR, Anasetti C, Sebti SM, Betts BC. Pidala J, et al. Among authors: lawrence nj. Clin Cancer Res. 2021 May 15;27(10):2712-2722. doi: 10.1158/1078-0432.CCR-20-4725. Epub 2021 Mar 22. Clin Cancer Res. 2021. PMID: 33753457 Free PMC article.
Discovery of a novel shp2 protein tyrosine phosphatase inhibitor.
Chen L, Sung SS, Yip ML, Lawrence HR, Ren Y, Guida WC, Sebti SM, Lawrence NJ, Wu J. Chen L, et al. Among authors: lawrence nj, lawrence hr. Mol Pharmacol. 2006 Aug;70(2):562-70. doi: 10.1124/mol.106.025536. Epub 2006 May 22. Mol Pharmacol. 2006. PMID: 16717135
Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity.
Siddiquee K, Zhang S, Guida WC, Blaskovich MA, Greedy B, Lawrence HR, Yip ML, Jove R, McLaughlin MM, Lawrence NJ, Sebti SM, Turkson J. Siddiquee K, et al. Among authors: lawrence nj, lawrence hr. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7391-6. doi: 10.1073/pnas.0609757104. Epub 2007 Apr 26. Proc Natl Acad Sci U S A. 2007. PMID: 17463090 Free PMC article.
Targeting protein tyrosine phosphatases for anticancer drug discovery.
Scott LM, Lawrence HR, Sebti SM, Lawrence NJ, Wu J. Scott LM, et al. Among authors: lawrence nj, lawrence hr. Curr Pharm Des. 2010 Jun;16(16):1843-62. doi: 10.2174/138161210791209027. Curr Pharm Des. 2010. PMID: 20337577 Free PMC article. Review.
The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane.
Berndt N, Yang H, Trinczek B, Betzi S, Zhang Z, Wu B, Lawrence NJ, Pellecchia M, Schönbrunn E, Cheng JQ, Sebti SM. Berndt N, et al. Among authors: lawrence nj. Cell Death Differ. 2010 Nov;17(11):1795-804. doi: 10.1038/cdd.2010.63. Epub 2010 May 21. Cell Death Differ. 2010. PMID: 20489726 Free PMC article.
Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112.
Chen L, Pernazza D, Scott LM, Lawrence HR, Ren Y, Luo Y, Wu X, Sung SS, Guida WC, Sebti SM, Lawrence NJ, Wu J. Chen L, et al. Among authors: lawrence nj, lawrence hr. Biochem Pharmacol. 2010 Sep 15;80(6):801-10. doi: 10.1016/j.bcp.2010.05.019. Epub 2010 May 25. Biochem Pharmacol. 2010. PMID: 20510203 Free PMC article.
120 results