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Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss.
Oncogene. 2021 Sep;40(38):5718-5729. doi: 10.1038/s41388-021-01926-y. Epub 2021 Jul 30.
Oncogene. 2021.
PMID: 34331013
Free PMC article.
Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain.
He S, Mansour MR, Zimmerman MW, Ki DH, Layden HM, Akahane K, Gjini E, de Groh ED, Perez-Atayde AR, Zhu S, Epstein JA, Look AT.
He S, et al. Among authors: layden hm.
Elife. 2016 Apr 27;5:e14713. doi: 10.7554/eLife.14713.
Elife. 2016.
PMID: 27130733
Free PMC article.
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Mutant FOXO1 controls an oncogenic network via enhancer accessibility.
Layden HM, Ellis JD, Bomber ML, Bartlett LN, Hiebert SW, Stengel KR.
Layden HM, et al.
Cell Genom. 2024 Apr 10;4(4):100537. doi: 10.1016/j.xgen.2024.100537.
Cell Genom. 2024.
PMID: 38604128
Free PMC article.
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Chemical-genetics refines transcription factor regulatory circuits.
Layden HM, Johnson AE, Hiebert SW.
Layden HM, et al.
Trends Cancer. 2024 Jan;10(1):65-75. doi: 10.1016/j.trecan.2023.08.012. Epub 2023 Sep 17.
Trends Cancer. 2024.
PMID: 37722945
Review.
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Jedi-1/MEGF12-mediated phagocytosis controls the pro-neurogenic properties of microglia in the ventricular-subventricular zone.
Morrison VE, Houpert MG, Trapani JB, Brockman AA, Kingsley PJ, Katdare KA, Layden HM, Nguena-Jones G, Trevisan AJ, Maguire-Zeiss KA, Marnett LJ, Bix GJ, Ihrie RA, Carter BD.
Morrison VE, et al. Among authors: layden hm.
bioRxiv [Preprint]. 2023 Mar 6:2023.03.03.531012. doi: 10.1101/2023.03.03.531012.
bioRxiv. 2023.
PMID: 36945622
Free PMC article.
Updated.
Preprint.
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Human SMARCA5 is continuously required to maintain nucleosome spacing.
Bomber ML, Wang J, Liu Q, Barnett KR, Layden HM, Hodges E, Stengel KR, Hiebert SW.
Bomber ML, et al. Among authors: layden hm.
Mol Cell. 2023 Feb 16;83(4):507-522.e6. doi: 10.1016/j.molcel.2022.12.018. Epub 2023 Jan 10.
Mol Cell. 2023.
PMID: 36630954
Free PMC article.
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PAX3-FOXO1 coordinates enhancer architecture, eRNA transcription, and RNA polymerase pause release at select gene targets.
Zhang S, Wang J, Liu Q, McDonald WH, Bomber ML, Layden HM, Ellis J, Borinstein SC, Hiebert SW, Stengel KR.
Zhang S, et al. Among authors: layden hm.
Mol Cell. 2022 Dec 1;82(23):4428-4442.e7. doi: 10.1016/j.molcel.2022.10.025. Epub 2022 Nov 16.
Mol Cell. 2022.
PMID: 36395771
Free PMC article.
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A protocol for rapid degradation of endogenous transcription factors in mammalian cells and identification of direct regulatory targets.
Layden HM, Eleuteri NA, Hiebert SW, Stengel KR.
Layden HM, et al.
STAR Protoc. 2021 May 19;2(2):100530. doi: 10.1016/j.xpro.2021.100530. eCollection 2021 Jun 18.
STAR Protoc. 2021.
PMID: 34041503
Free PMC article.
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