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Pericyte degeneration causes white matter dysfunction in the mouse central nervous system.
Montagne A, Nikolakopoulou AM, Zhao Z, Sagare AP, Si G, Lazic D, Barnes SR, Daianu M, Ramanathan A, Go A, Lawson EJ, Wang Y, Mack WJ, Thompson PM, Schneider JA, Varkey J, Langen R, Mullins E, Jacobs RE, Zlokovic BV. Montagne A, et al. Among authors: lazic d. Nat Med. 2018 Mar;24(3):326-337. doi: 10.1038/nm.4482. Epub 2018 Feb 5. Nat Med. 2018. PMID: 29400711 Free PMC article. Retracted.
Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss.
Nikolakopoulou AM, Montagne A, Kisler K, Dai Z, Wang Y, Huuskonen MT, Sagare AP, Lazic D, Sweeney MD, Kong P, Wang M, Owens NC, Lawson EJ, Xie X, Zhao Z, Zlokovic BV. Nikolakopoulou AM, et al. Among authors: lazic d. Nat Neurosci. 2019 Jul;22(7):1089-1098. doi: 10.1038/s41593-019-0434-z. Epub 2019 Jun 24. Nat Neurosci. 2019. PMID: 31235908 Free PMC article.
APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer's mice via cyclophilin A independently of amyloid-β.
Montagne A, Nikolakopoulou AM, Huuskonen MT, Sagare AP, Lawson EJ, Lazic D, Rege SV, Grond A, Zuniga E, Barnes SR, Prince J, Sagare M, Hsu CJ, LaDu MJ, Jacobs RE, Zlokovic BV. Montagne A, et al. Among authors: lazic d. Nat Aging. 2021 Jun;1(6):506-520. doi: 10.1038/s43587-021-00073-z. Epub 2021 Jun 14. Nat Aging. 2021. PMID: 35291561 Free PMC article.
183 results