Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1974 1
1981 1
1982 1
1985 2
1986 1
1989 2
1990 1
1991 3
1992 1
1993 2
1994 1
1995 3
1996 3
1997 1
1999 4
2000 1
2001 1
2002 2
2003 2
2005 2
2006 5
2007 6
2008 4
2009 6
2010 6
2011 5
2012 5
2013 10
2014 8
2015 9
2016 10
2017 16
2018 11
2019 19
2020 20
2021 17
2022 18
2023 17
2024 12

Text availability

Article attribute

Article type

Publication date

Search Results

217 results

Results by year

Filters applied: . Clear all
Page 1
Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression.
Zhang H, Wang L, Cui J, Wang S, Han Y, Shao H, Wang C, Hu Y, Li X, Zhou Q, Guo J, Zhuang X, Sheng S, Zhang T, Zhou D, Chen J, Wang F, Gao Q, Jing Y, Chen X, Su J. Zhang H, et al. Sci Adv. 2023 Apr 5;9(14):eabo7868. doi: 10.1126/sciadv.abo7868. Epub 2023 Apr 5. Sci Adv. 2023. PMID: 37018403 Free PMC article.
Abnormal subchondral bone remodeling featured by overactivated osteoclastogenesis leads to articular cartilage degeneration and osteoarthritis (OA) progression, but the mechanism is unclear. We used lymphocyte cytosolic protein 1 (Lcp1) knockout mice to suppress subchondra …
Abnormal subchondral bone remodeling featured by overactivated osteoclastogenesis leads to articular cartilage degeneration and osteoarthrit …
LCP1 knockdown in monocyte-derived macrophages: mitigating ischemic brain injury and shaping immune cell signaling and metabolism.
Wang Y, Yin Q, Yang D, Jin H, Yao Y, Song J, Liu C, Nie Y, Yin H, Wang W, Xu B, Xue L, Ji X, Chen X, Zhao H. Wang Y, et al. Theranostics. 2024 Jan 1;14(1):159-175. doi: 10.7150/thno.88678. eCollection 2024. Theranostics. 2024. PMID: 38164159 Free PMC article.
We have demonstrated that the long non-coding RNA (lncRNA) Maclpil silencing in monocyte-derived macrophages (MoDMs) led to LCP1 inhibition, reducing ischemic brain damage. However, the role of LCP1 of MoDMs in ischemic stroke remains unknown. ...In vitro experiment …
We have demonstrated that the long non-coding RNA (lncRNA) Maclpil silencing in monocyte-derived macrophages (MoDMs) led to LCP1 inhi …
LCP1 is a prognostic biomarker correlated with immune infiltrates in gastric cancer.
Zeng Q, Li L, Feng Z, Luo L, Xiong J, Jie Z, Cao Y, Li Z. Zeng Q, et al. Cancer Biomark. 2021;30(1):105-125. doi: 10.3233/CBM-200006. Cancer Biomark. 2021. PMID: 32986657
BACKGROUND: Previous studies have identified LCP1 as a diagnostic and prognostic marker in several cancers. However, the role of LCP1 in gastric cancer (GC) and its effect on tumor immune infiltration remain unclear. OBJECTIVE: The aim was to explore the role of …
BACKGROUND: Previous studies have identified LCP1 as a diagnostic and prognostic marker in several cancers. However, the role of L …
LCP1 triggers mTORC2/AKT activity and is pharmacologically targeted by enzastaurin in hypereosinophilia.
Ma G, Gezer D, Herrmann O, Feldberg K, Schemionek M, Jawhar M, Reiter A, Brümmendorf TH, Koschmieder S, Chatain N. Ma G, et al. Mol Carcinog. 2020 Jan;59(1):87-103. doi: 10.1002/mc.23131. Epub 2019 Nov 6. Mol Carcinog. 2020. PMID: 31691359
Therefore, we investigated the role of the actin-binding protein lymphocyte cytosolic protein 1 (LCP1) in malignant and nonmalignant eosinophil differentiation. We use the protein kinase C-beta (PKCbeta) selective inhibitor enzastaurin (Enza) to dephosphorylate and inactiv …
Therefore, we investigated the role of the actin-binding protein lymphocyte cytosolic protein 1 (LCP1) in malignant and nonmalignant …
Transcriptome Profiling Analysis Identifies LCP1 as a Contributor for Chidamide Resistance in Gastric Cancer.
Bao W, Zhu Z, Gao Y, Chen J. Bao W, et al. Pharm Res. 2022 May;39(5):867-876. doi: 10.1007/s11095-022-03291-1. Epub 2022 May 16. Pharm Res. 2022. PMID: 35578065
Overexpression of LCP1 conferred and knockdown of LCP1 attenuated the chidamide resistance of GC cells. Epigenetic derepression of LCP1 by chidamide may be a possible reason for the contribution of LCP1 to chidamide resistance. ...
Overexpression of LCP1 conferred and knockdown of LCP1 attenuated the chidamide resistance of GC cells. Epigenetic derepressio …
Inhibition of the Glycolysis Prevents the Cerebral Infarction Progression Through Decreasing the Lactylation Levels of LCP1.
Zhang W, Xu L, Yu Z, Zhang M, Liu J, Zhou J. Zhang W, et al. Mol Biotechnol. 2023 Aug;65(8):1336-1345. doi: 10.1007/s12033-022-00643-5. Epub 2022 Dec 27. Mol Biotechnol. 2023. PMID: 36574182 Free PMC article.
Immunoprecipitation and western blot was performed to test the lactylation levels of LCP1. The cells were treated with cycloheximide to determined the protein stability of LCP1. ...In conclusion, inhibiting the glycolysis decreased the lactylation levels of LCP1 …
Immunoprecipitation and western blot was performed to test the lactylation levels of LCP1. The cells were treated with cycloheximide …
Multi-omics prediction of immune-related adverse events during checkpoint immunotherapy.
Jing Y, Liu J, Ye Y, Pan L, Deng H, Wang Y, Yang Y, Diao L, Lin SH, Mills GB, Zhuang G, Xue X, Han L. Jing Y, et al. Nat Commun. 2020 Oct 2;11(1):4946. doi: 10.1038/s41467-020-18742-9. Nat Commun. 2020. PMID: 33009409 Free PMC article.
Here, we utilize a strategy that combines pharmacovigilance data and omics data, and evaluate associations between multi-omics factors and irAE reporting odds ratio across different cancer types. We identify a bivariate regression model of LCP1 and ADPGK that can accuratel …
Here, we utilize a strategy that combines pharmacovigilance data and omics data, and evaluate associations between multi-omics factors and i …
Exosomal Transfer of LCP1 Promotes Osteosarcoma Cell Tumorigenesis and Metastasis by Activating the JAK2/STAT3 Signaling Pathway.
Ge X, Liu W, Zhao W, Feng S, Duan A, Ji C, Shen K, Liu W, Zhou J, Jiang D, Rong Y, Gong F, Wang J, Xu Z, Li X, Fan J, Wei Y, Bai J, Cai W. Ge X, et al. Mol Ther Nucleic Acids. 2020 Sep 4;21:900-915. doi: 10.1016/j.omtn.2020.07.025. Epub 2020 Jul 23. Mol Ther Nucleic Acids. 2020. PMID: 32810692 Free PMC article.
We aimed to investigate the potential effect of LCP1 in OS and the underlying mechanisms. We first demonstrated that LCP1 is upregulated in OS cell lines and tissues. ...Targeting the miR-135a-5p/LCP1 axis may have potential in treating OS....
We aimed to investigate the potential effect of LCP1 in OS and the underlying mechanisms. We first demonstrated that LCP1 is u …
Lcp1 Is a Phosphotransferase Responsible for Ligating Arabinogalactan to Peptidoglycan in Mycobacterium tuberculosis.
Harrison J, Lloyd G, Joe M, Lowary TL, Reynolds E, Walters-Morgan H, Bhatt A, Lovering A, Besra GS, Alderwick LJ. Harrison J, et al. mBio. 2016 Aug 2;7(4):e00972-16. doi: 10.1128/mBio.00972-16. mBio. 2016. PMID: 27486192 Free PMC article.
In this study, we have identified Rv3267 as a mycobacterial LCP homolog gene that encodes a phosphotransferase which we have named Lcp1. We demonstrate that lcp1 is an essential gene required for cell viability and show that recombinant Lcp1 is capable of lig …
In this study, we have identified Rv3267 as a mycobacterial LCP homolog gene that encodes a phosphotransferase which we have named Lcp1 …
LCP1-mediated cytoskeleton alterations involve in arsenite-triggered malignant phenotype of human immortalized prostate stromal cells.
Yang Y, Zhou M, Huang Y, Ye X, Mo Y, Huang Y, Wang S. Yang Y, et al. Food Chem Toxicol. 2024 Apr;186:114548. doi: 10.1016/j.fct.2024.114548. Epub 2024 Feb 28. Food Chem Toxicol. 2024. PMID: 38417537
Quantitative proteomics identified 517 differentially expressed proteins (DEPs), of which the most remarkably changed proteins (such as LCP1 and DDX58, etc.) and the bioinformatic analysis were focused on the regulation of cytoskeleton, cell adhesion, and migration. Furthe …
Quantitative proteomics identified 517 differentially expressed proteins (DEPs), of which the most remarkably changed proteins (such as L …
217 results