Le Guennec JY - Search Results

1

Prediction of the risk of Torsade de Pointes using the model of isolated canine Purkinje fibres.

Champeroux P, Viaud K, El Amrani AI, Fowler JS, Martel E, Le Guennec JY, Richard S. Champeroux P, et al. Among authors: le guennec jy. Br J Pharmacol. 2005 Feb;144(3):376-85. doi: 10.1038/sj.bjp.0706070. Br J Pharmacol. 2005. PMID: 15655517 Free PMC article.

2

A step towards characterisation of electrophysiological profile of torsadogenic drugs.

Champeroux P, Ouillé A, Martel E, Fowler JS, Maurin A, Richard S, Le Guennec JY. Champeroux P, et al. Among authors: le guennec jy. J Pharmacol Toxicol Methods. 2011 May-Jun;63(3):269-78. doi: 10.1016/j.vascn.2011.01.001. Epub 2011 Jan 9. J Pharmacol Toxicol Methods. 2011. PMID: 21224008

3

High-frequency autonomic modulation: a new model for analysis of autonomic cardiac control.

Champéroux P, Fesler P, Judé S, Richard S, Le Guennec JY, Thireau J. Champéroux P, et al. Among authors: le guennec jy. Br J Pharmacol. 2018 Aug;175(15):3131-3143. doi: 10.1111/bph.14354. Epub 2018 Jun 15. Br J Pharmacol. 2018. PMID: 29723392 Free PMC article.

4

Contribution of haemodynamic side effects and associated autonomic reflexes to ventricular arrhythmias triggering by torsadogenic hERG blocking drugs.

Champéroux P, Fares R, Bastogne T, Richard S, Le Guennec JY, Thireau J. Champéroux P, et al. Among authors: le guennec jy. Br J Pharmacol. 2022 Sep;179(18):4549-4562. doi: 10.1111/bph.15905. Epub 2022 Jul 13. Br J Pharmacol. 2022. PMID: 35751378 Free PMC article.

5

Short-term variability in QT interval and ventricular arrhythmias induced by dofetilide are dependent on high-frequency autonomic oscillations.

Champeroux P, Thireau J, Judé S, Laigot-Barbé C, Maurin A, Sola ML, Fowler JS, Richard S, Le Guennec JY. Champeroux P, et al. Among authors: le guennec jy. Br J Pharmacol. 2015 Jun;172(11):2878-91. doi: 10.1111/bph.13093. Epub 2015 Mar 26. Br J Pharmacol. 2015. PMID: 25625756 Free PMC article.

6

The high frequency relationship: implications for torsadogenic hERG blockers.

Champeroux P, Le Guennec JY, Jude S, Laigot C, Maurin A, Sola ML, Fowler JS, Richard S, Thireau J. Champeroux P, et al. Among authors: le guennec jy. Br J Pharmacol. 2016 Feb;173(3):601-12. doi: 10.1111/bph.13391. Epub 2016 Jan 14. Br J Pharmacol. 2016. PMID: 26589499 Free PMC article.

7

Dietary long-chain n-3 fatty acids modify blood and cardiac phospholipids and reduce protein kinase-C-delta and protein kinase-C-epsilon translocation.

Judé S, Martel E, Vincent F, Besson P, Couet C, Ogilvie GK, Pinault M, De Chalendar C, Bougnoux P, Richard S, Champeroux P, Crozatier B, Le Guennec JY. Judé S, et al. Among authors: le guennec jy. Br J Nutr. 2007 Dec;98(6):1143-51. doi: 10.1017/S0007114507798914. Epub 2007 Jul 30. Br J Nutr. 2007. PMID: 17663802

8

Interferences of the autonomic nervous system with drug induced QT prolongation: a point to consider in non-clinical safety studies.

Champeroux P, Ouillé A, Martel E, Fowler JS, Maurin A, Jude S, Lala P, Le Guennec JY, Richard S. Champeroux P, et al. Among authors: le guennec jy. J Pharmacol Toxicol Methods. 2010 May-Jun;61(3):251-63. doi: 10.1016/j.vascn.2010.02.006. Epub 2010 Feb 19. J Pharmacol Toxicol Methods. 2010. PMID: 20172034

9

Inter-individual variability and modeling of electrical activity: a possible new approach to explore cardiac safety?

Le Guennec JY, Thireau J, Ouillé A, Roussel J, Roy J, Richard S, Richard S, Martel E, Champéroux P. Le Guennec JY, et al. Sci Rep. 2016 Nov 30;6:37948. doi: 10.1038/srep37948. Sci Rep. 2016. PMID: 27901061 Free PMC article.

10

The preclinical assessment of the risk for QT interval prolongation.

Champeroux P, Martel E, Vannier C, Blanc V, Leguennec JY, Fowler J, Richard S. Champeroux P, et al. Therapie. 2000 Jan-Feb;55(1):101-9. Therapie. 2000. PMID: 10860008 Review.

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