Lebeau PF - Search Results

1

Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance.

Lebeau PF, Byun JH, Platko K, Saliba P, Sguazzin M, MacDonald ME, Paré G, Steinberg GR, Janssen LJ, Igdoura SA, Tarnopolsky MA, Wayne Chen SR, Seidah NG, Magolan J, Austin RC. Lebeau PF, et al. Nat Commun. 2022 Feb 9;13(1):770. doi: 10.1038/s41467-022-28240-9. Nat Commun. 2022. PMID: 35140212 Free PMC article.

2

Endoplasmic Reticulum Stress and Ca2+ Depletion Differentially Modulate the Sterol Regulatory Protein PCSK9 to Control Lipid Metabolism.

Lebeau P, Al-Hashimi A, Sood S, Lhoták Š, Yu P, Gyulay G, Paré G, Chen SR, Trigatti B, Prat A, Seidah NG, Austin RC. Lebeau P, et al. J Biol Chem. 2017 Jan 27;292(4):1510-1523. doi: 10.1074/jbc.M116.744235. Epub 2016 Dec 1. J Biol Chem. 2017. PMID: 27909053 Free PMC article.

3

Autoantibodies against the cell surface-associated chaperone GRP78 stimulate tumor growth via tissue factor.

Al-Hashimi AA, Lebeau P, Majeed F, Polena E, Lhotak Š, Collins CAF, Pinthus JH, Gonzalez-Gronow M, Hoogenes J, Pizzo SV, Crowther M, Kapoor A, Rak J, Gyulay G, D'Angelo S, Marchiò S, Pasqualini R, Arap W, Shayegan B, Austin RC. Al-Hashimi AA, et al. J Biol Chem. 2017 Dec 22;292(51):21180-21192. doi: 10.1074/jbc.M117.799908. Epub 2017 Oct 24. J Biol Chem. 2017. PMID: 29066620 Free PMC article.

4

Rosuvastatin Reduces Aortic Sinus and Coronary Artery Atherosclerosis in SR-B1 (Scavenger Receptor Class B Type 1)/ApoE (Apolipoprotein E) Double Knockout Mice Independently of Plasma Cholesterol Lowering.

Yu P, Xiong T, Tenedero CB, Lebeau P, Ni R, MacDonald ME, Gross PL, Austin RC, Trigatti BL. Yu P, et al. Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):26-39. doi: 10.1161/ATVBAHA.117.305140. Epub 2017 Nov 21. Arterioscler Thromb Vasc Biol. 2018. PMID: 29162602 Free PMC article.

5

Loss-of-function PCSK9 mutants evade the unfolded protein response sensor GRP78 and fail to induce endoplasmic reticulum stress when retained.

Lebeau P, Platko K, Al-Hashimi AA, Byun JH, Lhoták Š, Holzapfel N, Gyulay G, Igdoura SA, Cool DR, Trigatti B, Seidah NG, Austin RC. Lebeau P, et al. J Biol Chem. 2018 May 11;293(19):7329-7343. doi: 10.1074/jbc.RA117.001049. Epub 2018 Mar 28. J Biol Chem. 2018. PMID: 29593095 Free PMC article.

6

Pharmacologic inhibition of S1P attenuates ATF6 expression, causes ER stress and contributes to apoptotic cell death.

Lebeau P, Byun JH, Yousof T, Austin RC. Lebeau P, et al. Toxicol Appl Pharmacol. 2018 Jun 15;349:1-7. doi: 10.1016/j.taap.2018.04.020. Epub 2018 Apr 22. Toxicol Appl Pharmacol. 2018. PMID: 29689241

7

MAPping the kinase landscape of macrophage activation.

Platko K, Lebeau P, Austin RC. Platko K, et al. J Biol Chem. 2018 Jun 22;293(25):9910-9911. doi: 10.1074/jbc.H118.003380. J Biol Chem. 2018. PMID: 29934367 Free PMC article.

8

Anti-GRP78 autoantibodies induce endothelial cell activation and accelerate the development of atherosclerotic lesions.

Crane ED, Al-Hashimi AA, Chen J, Lynn EG, Won KD, Lhoták Š, Naeim M, Platko K, Lebeau P, Byun JH, Shayegan B, Krepinsky JC, Rayner KJ, Marchiò S, Pasqualini R, Arap W, Austin RC. Crane ED, et al. JCI Insight. 2018 Dec 20;3(24):e99363. doi: 10.1172/jci.insight.99363. JCI Insight. 2018. PMID: 30568038 Free PMC article.

9

4-Phenylbutyrate protects against atherosclerotic lesion growth by increasing the expression of HSP25 in macrophages and in the circulation of Apoe^-/- mice.

Lynn EG, Lhoták Š, Lebeau P, Byun JH, Chen J, Platko K, Shi C, O'Brien ER, Austin RC. Lynn EG, et al. FASEB J. 2019 Jul;33(7):8406-8422. doi: 10.1096/fj.201802293RR. Epub 2019 Apr 9. FASEB J. 2019. PMID: 30964709

10

Diet-induced hepatic steatosis abrogates cell-surface LDLR by inducing de novo PCSK9 expression in mice.

Lebeau PF, Byun JH, Platko K, MacDonald ME, Poon SV, Faiyaz M, Seidah NG, Austin RC. Lebeau PF, et al. J Biol Chem. 2019 Jun 7;294(23):9037-9047. doi: 10.1074/jbc.RA119.008094. Epub 2019 Apr 19. J Biol Chem. 2019. PMID: 31004037 Free PMC article.

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