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Page 1
Developments in the Treatment of Leber Hereditary Optic Neuropathy.
Chen BS, Yu-Wai-Man P, Newman NJ. Chen BS, et al. Curr Neurol Neurosci Rep. 2022 Dec;22(12):881-892. doi: 10.1007/s11910-022-01246-y. Epub 2022 Nov 21. Curr Neurol Neurosci Rep. 2022. PMID: 36414808 Free PMC article. Review.
PURPOSEOF REVIEW: To outline the current landscape of treatments for Leber hereditary optic neuropathy (LHON) along the therapeutic delivery pipeline, exploring the mechanisms of action and evidence for these therapeutic approaches. ...
PURPOSEOF REVIEW: To outline the current landscape of treatments for Leber hereditary optic neuropathy (LHON) along the …
Dominant Optic Atrophy and Leber's Hereditary Optic Neuropathy: Update on Clinical Features and Current Therapeutic Approaches.
Chun BY, Rizzo JF 3rd. Chun BY, et al. Semin Pediatr Neurol. 2017 May;24(2):129-134. doi: 10.1016/j.spen.2017.06.001. Epub 2017 Jun 30. Semin Pediatr Neurol. 2017. PMID: 28941528 Review.
Dominant optic atrophy (DOA) and Leber hereditary optic neuropathy (LHON) are the two most common inherited optic neuropathies encountered in clinical practice. ...Pathogenic OPA1 gene mutations in DOA and 3 primary mutations of mitochond …
Dominant optic atrophy (DOA) and Leber hereditary optic neuropathy (LHON) are the two most common inherit …
[Leber's hereditary optic neuropathy].
Biousse V. Biousse V. J Fr Ophtalmol. 2022 Nov;45(8 Suppl 1):S1-S2. doi: 10.1016/S0181-5512(22)00443-0. J Fr Ophtalmol. 2022. PMID: 36529472 French. No abstract available.
Leber's Hereditary Optic Neuropathy: Novel Views and Persisting Challenges.
Jancic J, Samardzic J, Stojanovic S, Stojanovic A, Milanovic AM, Nikolic B, Ivancevic N, Kostic V. Jancic J, et al. CNS Neurol Disord Drug Targets. 2017;16(8):927-935. doi: 10.2174/1871527316666170724172455. CNS Neurol Disord Drug Targets. 2017. PMID: 28745242 Review.
BACKGROUND & OBJECTIVE: Leber's hereditary optic neuropathy is an inherited form of optic neuropathy, genetically and pathophysiologically based on mitochondrial insufficiency causing bilateral loss of central vision mostly amongst young adults. .. …
BACKGROUND & OBJECTIVE: Leber's hereditary optic neuropathy is an inherited form of optic neuropathy, geneti …
Leber hereditary optic neuropathy: new and emerging therapies.
Davila-Siliezar P, Carter M, Milea D, Lee AG. Davila-Siliezar P, et al. Curr Opin Ophthalmol. 2022 Nov 1;33(6):574-578. doi: 10.1097/ICU.0000000000000891. Epub 2022 Aug 24. Curr Opin Ophthalmol. 2022. PMID: 36066375 Review.
PURPOSE OF REVIEW: To review recent therapeutic advances in Leber hereditary optic neuropathy (LHON). RECENT FINDINGS: Idebenone, a synthetic analog of ubiquinone (Coenzyme Q10) is an antioxidant and component of the mitochondrial electron transport chain. .. …
PURPOSE OF REVIEW: To review recent therapeutic advances in Leber hereditary optic neuropathy (LHON). RECENT FINDINGS: …
[Leber hereditary optic neuropathy: differential diagnosis].
Orssaud C. Orssaud C. J Fr Ophtalmol. 2022 Nov;45(8S1):S9-S16. doi: 10.1016/S0181-5512(22)00445-4. J Fr Ophtalmol. 2022. PMID: 36529477 French.
The diagnosis of Leber hereditary optic neuropathy is suspected in the siblings of an affected person that complains of a decrease in visual acuity. It can also be suspected in a young subject, especially a male, with no medical history that presents with an …
The diagnosis of Leber hereditary optic neuropathy is suspected in the siblings of an affected person that complains of …
Leber hereditary optic neuropathy-new insights and old challenges.
Sundaramurthy S, SelvaKumar A, Ching J, Dharani V, Sarangapani S, Yu-Wai-Man P. Sundaramurthy S, et al. Graefes Arch Clin Exp Ophthalmol. 2021 Sep;259(9):2461-2472. doi: 10.1007/s00417-020-04993-1. Epub 2020 Nov 13. Graefes Arch Clin Exp Ophthalmol. 2021. PMID: 33185731 Review.
Leber hereditary optic neuropathy (LHON) is the most common primary mitochondrial DNA (mtDNA) disorder with the majority of patients harboring one of three primary mtDNA point mutations, namely, m.3460G>A (MTND1), m.11778G>A (MTND4), and m.14484T>C ( …
Leber hereditary optic neuropathy (LHON) is the most common primary mitochondrial DNA (mtDNA) disorder with the majorit …
Leber Hereditary Optic Neuropathy-Light at the End of the Tunnel?
Kim US, Jurkute N, Yu-Wai-Man P. Kim US, et al. Asia Pac J Ophthalmol (Phila). 2018 Jul-Aug;7(4):242-245. doi: 10.22608/APO.2018293. Epub 2018 Jul 15. Asia Pac J Ophthalmol (Phila). 2018. PMID: 30008192 Free article. Review.
Leber hereditary optic neuropathy (LHON) is an important cause of mitochondrial blindness. ...
Leber hereditary optic neuropathy (LHON) is an important cause of mitochondrial blindness. ...
1,660 results