Leclercq K - Search Results

1

Lack of synaptic vesicle protein SV2B protects against amyloid-β₂₅₋₃₅-induced oxidative stress, cholinergic deficit and cognitive impairment in mice.

Detrait E, Maurice T, Hanon E, Leclercq K, Lamberty Y. Detrait E, et al. Among authors: leclercq k. Behav Brain Res. 2014 Sep 1;271:277-85. doi: 10.1016/j.bbr.2014.06.013. Epub 2014 Jun 14. Behav Brain Res. 2014. PMID: 24937053

2

Behavioural phenotyping reveals anxiety-like features of SV2A deficient mice.

Lamberty Y, Detrait E, Leclercq K, Michel A, De Ryck M. Lamberty Y, et al. Among authors: leclercq k. Behav Brain Res. 2009 Mar 17;198(2):329-33. doi: 10.1016/j.bbr.2008.11.005. Epub 2008 Nov 11. Behav Brain Res. 2009. PMID: 19041904

3

Proepileptic phenotype of SV2A-deficient mice is associated with reduced anticonvulsant efficacy of levetiracetam.

Kaminski RM, Gillard M, Leclercq K, Hanon E, Lorent G, Dassesse D, Matagne A, Klitgaard H. Kaminski RM, et al. Among authors: leclercq k. Epilepsia. 2009 Jul;50(7):1729-40. doi: 10.1111/j.1528-1167.2009.02089.x. Epub 2009 Apr 19. Epilepsia. 2009. PMID: 19486357 Free article.

4

Brivaracetam: Rationale for discovery and preclinical profile of a selective SV2A ligand for epilepsy treatment.

Klitgaard H, Matagne A, Nicolas JM, Gillard M, Lamberty Y, De Ryck M, Kaminski RM, Leclercq K, Niespodziany I, Wolff C, Wood M, Hannestad J, Kervyn S, Kenda B. Klitgaard H, et al. Among authors: leclercq k. Epilepsia. 2016 Apr;57(4):538-48. doi: 10.1111/epi.13340. Epub 2016 Feb 26. Epilepsia. 2016. PMID: 26920914 Free article. Review.

5

Unraveling the mechanism and the risk behind seizure liability of lead compounds in a neuroscience project.

Delaunois A, Accardi MV, André V, Authier S, Bouzom F, Hebeisen S, Lamberty Y, Laredj F, Leclercq K, Letombe AG, Rosseels ML, Rospo CC, Tordeur MC, Valentin JP, Wood M. Delaunois A, et al. Among authors: leclercq k. J Pharmacol Toxicol Methods. 2020 Jul-Aug;104:106874. doi: 10.1016/j.vascn.2020.106874. Epub 2020 May 22. J Pharmacol Toxicol Methods. 2020. PMID: 32446729

6

Discovery of indolone acetamides as novel SV2A ligands with improved potency toward seizure suppression.

Frycia A, Starck JP, Jadot S, Lallemand B, Leclercq K, Lo Brutto P, Matagne A, Verbois V, Mercier J, Kenda B. Frycia A, et al. Among authors: leclercq k. ChemMedChem. 2010 Feb 1;5(2):200-5. doi: 10.1002/cmdc.200900436. ChemMedChem. 2010. PMID: 20039359 No abstract available.

7

SV2A protein is a broad-spectrum anticonvulsant target: functional correlation between protein binding and seizure protection in models of both partial and generalized epilepsy.

Kaminski RM, Matagne A, Leclercq K, Gillard M, Michel P, Kenda B, Talaga P, Klitgaard H. Kaminski RM, et al. Among authors: leclercq k. Neuropharmacology. 2008 Mar;54(4):715-20. doi: 10.1016/j.neuropharm.2007.11.021. Epub 2007 Dec 8. Neuropharmacology. 2008. PMID: 18207204

8

Binding characteristics of brivaracetam, a selective, high affinity SV2A ligand in rat, mouse and human brain: relationship to anti-convulsant properties.

Gillard M, Fuks B, Leclercq K, Matagne A. Gillard M, et al. Among authors: leclercq k. Eur J Pharmacol. 2011 Aug 16;664(1-3):36-44. doi: 10.1016/j.ejphar.2011.04.064. Epub 2011 May 8. Eur J Pharmacol. 2011. PMID: 21575627

9

11-Deoxycortisol impedes GABAergic neurotransmission and induces drug-resistant status epilepticus in mice.

Kaminski RM, Fu Z, Venkatesan K, Mazzuferi M, Leclercq K, Seutin V, Vicini S. Kaminski RM, et al. Among authors: leclercq k. Neuropharmacology. 2011 Jun;60(7-8):1098-108. doi: 10.1016/j.neuropharm.2010.09.021. Epub 2010 Sep 29. Neuropharmacology. 2011. PMID: 20883706 Free PMC article.

10

Status epilepticus induction has prolonged effects on the efficacy of antiepileptic drugs in the 6-Hz seizure model.

Leclercq K, Kaminski RM. Leclercq K, et al. Epilepsy Behav. 2015 Aug;49:55-60. doi: 10.1016/j.yebeh.2015.06.011. Epub 2015 Jun 27. Epilepsy Behav. 2015. PMID: 26123104

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