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Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk.
Das Pradhan A, Glynn RJ, Fruchart JC, MacFadyen JG, Zaharris ES, Everett BM, Campbell SE, Oshima R, Amarenco P, Blom DJ, Brinton EA, Eckel RH, Elam MB, Felicio JS, Ginsberg HN, Goudev A, Ishibashi S, Joseph J, Kodama T, Koenig W, Leiter LA, Lorenzatti AJ, Mankovsky B, Marx N, Nordestgaard BG, Páll D, Ray KK, Santos RD, Soran H, Susekov A, Tendera M, Yokote K, Paynter NP, Buring JE, Libby P, Ridker PM; PROMINENT Investigators. Das Pradhan A, et al. N Engl J Med. 2022 Nov 24;387(21):1923-1934. doi: 10.1056/NEJMoa2210645. Epub 2022 Nov 5. N Engl J Med. 2022. PMID: 36342113 Clinical Trial.
As compared with placebo, the effects of pemafibrate on lipid levels at 4 months were -26.2% for triglycerides, -25.8% for very-low-density lipoprotein (VLDL) cholesterol, -25.6% for remnant cholesterol (cholesterol transported in triglyceride-rich lipoproteins after lipolysis an …
As compared with placebo, the effects of pemafibrate on lipid levels at 4 months were -26.2% for triglycerides, -25.8% for very-low-density …
Transforming growth factor-alpha stimulates proto-oncogene c-jun expression and a mitogenic program in primary cultures of adult rat hepatocytes.
Brenner DA, Koch KS, Leffert HL. Brenner DA, et al. DNA. 1989 May;8(4):279-85. doi: 10.1089/dna.1.1989.8.279. DNA. 1989. PMID: 2504570
Using validated growth reinitiation assays and chemically defined conditions (Koch and Leffert, 1979a) that simulate proto-oncogene expression in regenerating liver (Kruijer et al., 1986), we find that 5.4 nM TGF-alpha stimulates: (i) increases in rates of amiloride-sensit …
Using validated growth reinitiation assays and chemically defined conditions (Koch and Leffert, 1979a) that simulate proto-oncogene e …
Targeted deletion of hepatocyte Ikkbeta confers growth advantages.
Koch KS, Maeda S, He G, Karin M, Leffert HL. Koch KS, et al. Biochem Biophys Res Commun. 2009 Mar 6;380(2):349-54. doi: 10.1016/j.bbrc.2009.01.085. Epub 2009 Jan 24. Biochem Biophys Res Commun. 2009. PMID: 19171122 Free PMC article.
Ikkbeta(Delta hep) hepatocyte proliferative responses show heightened sensitivity to TGFalpha and TNFalpha, and heightened expression of fibronectin, collagens I/III, nidogen, beta-actin and integrin beta1 mRNAs. These findings suggest that altered mitogen signaling and ex …
Ikkbeta(Delta hep) hepatocyte proliferative responses show heightened sensitivity to TGFalpha and TNFalpha, and heightened expression of fib …
Hypertensive disorders and pregnancy-related stroke: frequency, trends, risk factors, and outcomes.
Leffert LR, Clancy CR, Bateman BT, Bryant AS, Kuklina EV. Leffert LR, et al. Obstet Gynecol. 2015 Jan;125(1):124-131. doi: 10.1097/AOG.0000000000000590. Obstet Gynecol. 2015. PMID: 25560114 Free PMC article.
Stroke with hypertensive disorders in pregnancy had two distinctive characteristics: a greater increase in frequency since the mid-1990s and significantly higher stroke-related complication rates. LEVEL OF EVIDENCE: III....
Stroke with hypertensive disorders in pregnancy had two distinctive characteristics: a greater increase in frequency since the mid-1990s and …
Increased peripheral blood expression of electron transport chain genes in bipolar depression.
Beech RD, Lowthert L, Leffert JJ, Mason PN, Taylor MM, Umlauf S, Lin A, Lee JY, Maloney K, Muralidharan A, Lorberg B, Zhao H, Newton SS, Mane S, Epperson CN, Sinha R, Blumberg H, Bhagwagar Z. Beech RD, et al. Bipolar Disord. 2010 Dec;12(8):813-24. doi: 10.1111/j.1399-5618.2010.00882.x. Bipolar Disord. 2010. PMID: 21176028 Free PMC article.
Of the 85 objects (genes or proteins) in this pathway, 22 were up-regulated and 2 down-regulated in subjects with BPD. qRT-PCR confirmed up-regulation of nuclear encoded ETC genes in complexes I, III, IV, and V and, in addition, demonstrated up-regulation of mitochondriall …
Of the 85 objects (genes or proteins) in this pathway, 22 were up-regulated and 2 down-regulated in subjects with BPD. qRT-PCR confirmed up- …
Differential expression of the transfected liver-specific alpha 1-inhibitor III gene in normal hepatocytes and hepatoma cells in culture.
Koch KS, Lu XP, Brenner DA, Leffert HL. Koch KS, et al. Biochem Biophys Res Commun. 1992 Feb 28;183(1):184-92. doi: 10.1016/0006-291x(92)91626-2. Biochem Biophys Res Commun. 1992. PMID: 1543489
Normal and malignant hepatocytes were transfected during log phase culture with a nested series of DNA plasmids containing 5'-flanking regions of the rat liver-specific acute phase plasma proteinase alpha 1-inhibitor III (alpha 1 I3) gene. Under these conditions, luciferas …
Normal and malignant hepatocytes were transfected during log phase culture with a nested series of DNA plasmids containing 5'-flanking regio …