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The Legionella autoinducer LAI-1 is delivered by outer membrane vesicles to promote interbacterial and interkingdom signaling.
Fan M, Kiefer P, Charki P, Hedberg C, Seibel J, Vorholt JA, Hilbi H. Fan M, et al. J Biol Chem. 2023 Dec;299(12):105376. doi: 10.1016/j.jbc.2023.105376. Epub 2023 Oct 20. J Biol Chem. 2023. PMID: 37866633 Free PMC article.
The opportunistic pathogen employs the alpha-hydroxy-ketone compound Legionella autoinducer-1 (LAI-1) for intraspecies and interkingdom signaling. LAI-1 is produced by the autoinducer synthase Legionella quorum sensing A (LqsA), but it is not known, ho …
The opportunistic pathogen employs the alpha-hydroxy-ketone compound Legionella autoinducer-1 (LAI-1) for intraspecies …
Legionella quorum sensing meets cyclic-di-GMP signaling.
Hochstrasser R, Hilbi H. Hochstrasser R, et al. Curr Opin Microbiol. 2020 Jun;55:9-16. doi: 10.1016/j.mib.2020.01.001. Epub 2020 Feb 8. Curr Opin Microbiol. 2020. PMID: 32045871 Review.
As an exogenous cue, nitric oxide controls the c-di-GMP regulatory network of L. pneumophila. The Legionella quorum sensing (Lqs) system regulates virulence, motility and natural competence of L. pneumophila. ...In this review, we highlight recent insights into the crossta …
As an exogenous cue, nitric oxide controls the c-di-GMP regulatory network of L. pneumophila. The Legionella quorum sensing (Lqs) sys …
The structure of the Legionella response regulator LqsR reveals amino acids critical for phosphorylation and dimerization.
Hochstrasser R, Hutter CAJ, Arnold FM, Bärlocher K, Seeger MA, Hilbi H. Hochstrasser R, et al. Mol Microbiol. 2020 Jun;113(6):1070-1084. doi: 10.1111/mmi.14477. Epub 2020 Feb 12. Mol Microbiol. 2020. PMID: 31997467 Free article.
L. pneumophila employs the Legionella quorum sensing (Lqs) system to control its life cycle, pathogen-host cell interactions, motility and natural competence. Signaling through the Lqs system occurs through the alpha-hydroxyketone compound Legionella autoinducer …
L. pneumophila employs the Legionella quorum sensing (Lqs) system to control its life cycle, pathogen-host cell interactions, motilit …
The pleiotropic Legionella transcription factor LvbR links the Lqs and c-di-GMP regulatory networks to control biofilm architecture and virulence.
Hochstrasser R, Kessler A, Sahr T, Simon S, Schell U, Gomez-Valero L, Buchrieser C, Hilbi H. Hochstrasser R, et al. Environ Microbiol. 2019 Mar;21(3):1035-1053. doi: 10.1111/1462-2920.14523. Epub 2019 Feb 22. Environ Microbiol. 2019. PMID: 30623561
The causative agent of Legionnaires' disease, Legionella pneumophila, colonizes amoebae and biofilms in the environment. The opportunistic pathogen employs the Lqs (Legionella quorum sensing) system and the signalling molecule LAI-1 (Legionella autoinducer …
The causative agent of Legionnaires' disease, Legionella pneumophila, colonizes amoebae and biofilms in the environment. The opportun …
Legionella quorum sensing and its role in pathogen-host interactions.
Personnic N, Striednig B, Hilbi H. Personnic N, et al. Curr Opin Microbiol. 2018 Feb;41:29-35. doi: 10.1016/j.mib.2017.11.010. Epub 2017 Nov 27. Curr Opin Microbiol. 2018. PMID: 29190490 Review.
Legionella pneumophila is a water-borne opportunistic pathogen causing a life-threatening pneumonia called 'Legionnaires' disease'. The Legionella quorum sensing (Lqs) system produces and responds to the alpha-hydroxyketone signaling molecule 3-hydroxypentadecane-4- …
Legionella pneumophila is a water-borne opportunistic pathogen causing a life-threatening pneumonia called 'Legionnaires' disease'. T …
Characterization of a novel signal transducer element intrinsic to class IIIa/b adenylate cyclases and guanylate cyclases.
Ziegler M, Bassler J, Beltz S, Schultz A, Lupas AN, Schultz JE. Ziegler M, et al. FEBS J. 2017 Apr;284(8):1204-1217. doi: 10.1111/febs.14047. Epub 2017 Mar 20. FEBS J. 2017. PMID: 28222489 Free article.
To address this question, we replaced the hexahelical membrane anchor of the mycobacterial AC Rv1625c with the hexahelical quorum-sensing receptor from Legionella, LqsS. Using this chimera, we identified a novel 19-amino-acid cyclase transducer element (CTE) located N-term …
To address this question, we replaced the hexahelical membrane anchor of the mycobacterial AC Rv1625c with the hexahelical quorum-sensing re …
Intra-Species and Inter-Kingdom Signaling of Legionella pneumophila.
Hochstrasser R, Hilbi H. Hochstrasser R, et al. Front Microbiol. 2017 Feb 3;8:79. doi: 10.3389/fmicb.2017.00079. eCollection 2017. Front Microbiol. 2017. PMID: 28217110 Free PMC article. Review.
The ubiquitous Gram-negative bacterium Legionella pneumophila parasitizes environ mental amoebae and, upon inhalation, replicates in alveolar macrophages, thus causing a life-threatening pneumonia called "Legionnaires' disease." ...These components produce, detect, and res …
The ubiquitous Gram-negative bacterium Legionella pneumophila parasitizes environ mental amoebae and, upon inhalation, replicates in …
Inter-kingdom Signaling by the Legionella Quorum Sensing Molecule LAI-1 Modulates Cell Migration through an IQGAP1-Cdc42-ARHGEF9-Dependent Pathway.
Simon S, Schell U, Heuer N, Hager D, Albers MF, Matthias J, Fahrnbauer F, Trauner D, Eichinger L, Hedberg C, Hilbi H. Simon S, et al. PLoS Pathog. 2015 Dec 3;11(12):e1005307. doi: 10.1371/journal.ppat.1005307. eCollection 2015 Dec. PLoS Pathog. 2015. PMID: 26633832 Free PMC article.
Small molecule signaling promotes the communication between bacteria as well as between bacteria and eukaryotes. The opportunistic pathogenic bacterium Legionella pneumophila employs LAI-1 (3-hydroxypentadecane-4-one) for bacterial cell-cell communication. LAI-1 is produce …
Small molecule signaling promotes the communication between bacteria as well as between bacteria and eukaryotes. The opportunistic pathogeni …
The Legionella pneumophila orphan sensor kinase LqsT regulates competence and pathogen-host interactions as a component of the LAI-1 circuit.
Kessler A, Schell U, Sahr T, Tiaden A, Harrison C, Buchrieser C, Hilbi H. Kessler A, et al. Environ Microbiol. 2013 Feb;15(2):646-62. doi: 10.1111/j.1462-2920.2012.02889.x. Epub 2012 Oct 4. Environ Microbiol. 2013. PMID: 23033905
Legionella pneumophila is an amoeba-resistant opportunistic pathogen that performs cell-cell communication through the signalling molecule 3-hydroxypentadecane-4-one (LAI-1, Legionella autoinducer-1). The lqs (Legionella quorum sensing) gene clu …
Legionella pneumophila is an amoeba-resistant opportunistic pathogen that performs cell-cell communication through the signalling mol …
alpha-Hydroxyketone synthesis and sensing by Legionella and Vibrio.
Tiaden A, Hilbi H. Tiaden A, et al. Sensors (Basel). 2012;12(3):2899-919. doi: 10.3390/s120302899. Epub 2012 Mar 2. Sensors (Basel). 2012. PMID: 22736983 Free PMC article. Review.
One class of autoinducers, the alpha-hydroxyketones (AHKs), is produced and detected by the water-borne opportunistic pathogens Legionella pneumophila and Vibrio cholerae, which cause Legionnaires' disease and cholera, respectively. The "Legionella quorum sensing" ( …
One class of autoinducers, the alpha-hydroxyketones (AHKs), is produced and detected by the water-borne opportunistic pathogens Legionell …
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