Lehrach H - Search Results

1

Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation.

Waelter S, Boeddrich A, Lurz R, Scherzinger E, Lueder G, Lehrach H, Wanker EE. Waelter S, et al. Among authors: lehrach h. Mol Biol Cell. 2001 May;12(5):1393-407. doi: 10.1091/mbc.12.5.1393. Mol Biol Cell. 2001. PMID: 11359930 Free PMC article.

2

Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington's disease.

Busch A, Engemann S, Lurz R, Okazawa H, Lehrach H, Wanker EE. Busch A, et al. Among authors: lehrach h. J Biol Chem. 2003 Oct 17;278(42):41452-61. doi: 10.1074/jbc.M303354200. Epub 2003 Jul 29. J Biol Chem. 2003. PMID: 12888569 Free article.

3

A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.

Goehler H, Lalowski M, Stelzl U, Waelter S, Stroedicke M, Worm U, Droege A, Lindenberg KS, Knoblich M, Haenig C, Herbst M, Suopanki J, Scherzinger E, Abraham C, Bauer B, Hasenbank R, Fritzsche A, Ludewig AH, Büssow K, Coleman SH, Gutekunst CA, Landwehrmeyer BG, Lehrach H, Wanker EE. Goehler H, et al. Among authors: lehrach h. Mol Cell. 2004 Sep 24;15(6):853-65. doi: 10.1016/j.molcel.2004.09.016. Mol Cell. 2004. PMID: 15383276 Free article.

4

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo.

Scherzinger E, Lurz R, Turmaine M, Mangiarini L, Hollenbach B, Hasenbank R, Bates GP, Davies SW, Lehrach H, Wanker EE. Scherzinger E, et al. Among authors: lehrach h. Cell. 1997 Aug 8;90(3):549-58. doi: 10.1016/s0092-8674(00)80514-0. Cell. 1997. PMID: 9267034 Free article.

5

SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates.

Sittler A, Wälter S, Wedemeyer N, Hasenbank R, Scherzinger E, Eickhoff H, Bates GP, Lehrach H, Wanker EE. Sittler A, et al. Among authors: lehrach h. Mol Cell. 1998 Oct;2(4):427-36. doi: 10.1016/s1097-2765(00)80142-2. Mol Cell. 1998. PMID: 9809064 Free article.

6

Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology.

Scherzinger E, Sittler A, Schweiger K, Heiser V, Lurz R, Hasenbank R, Bates GP, Lehrach H, Wanker EE. Scherzinger E, et al. Among authors: lehrach h. Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4604-9. doi: 10.1073/pnas.96.8.4604. Proc Natl Acad Sci U S A. 1999. PMID: 10200309 Free PMC article.

7

Aggregation of truncated GST-HD exon 1 fusion proteins containing normal range and expanded glutamine repeats.

Hollenbach B, Scherzinger E, Schweiger K, Lurz R, Lehrach H, Wanker EE. Hollenbach B, et al. Among authors: lehrach h. Philos Trans R Soc Lond B Biol Sci. 1999 Jun 29;354(1386):991-4. doi: 10.1098/rstb.1999.0450. Philos Trans R Soc Lond B Biol Sci. 1999. PMID: 10434297 Free PMC article.

8

Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy.

Heiser V, Scherzinger E, Boeddrich A, Nordhoff E, Lurz R, Schugardt N, Lehrach H, Wanker EE. Heiser V, et al. Among authors: lehrach h. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6739-44. doi: 10.1073/pnas.110138997. Proc Natl Acad Sci U S A. 2000. PMID: 10829068 Free PMC article.

9

Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease.

Sittler A, Lurz R, Lueder G, Priller J, Lehrach H, Hayer-Hartl MK, Hartl FU, Wanker EE. Sittler A, et al. Among authors: lehrach h. Hum Mol Genet. 2001 Jun 1;10(12):1307-15. doi: 10.1093/hmg/10.12.1307. Hum Mol Genet. 2001. PMID: 11406612

10

The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis.

Waelter S, Scherzinger E, Hasenbank R, Nordhoff E, Lurz R, Goehler H, Gauss C, Sathasivam K, Bates GP, Lehrach H, Wanker EE. Waelter S, et al. Among authors: lehrach h. Hum Mol Genet. 2001 Aug 15;10(17):1807-17. doi: 10.1093/hmg/10.17.1807. Hum Mol Genet. 2001. PMID: 11532990

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