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Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis.
Xu XR, Wang Y, Adili R, Ju L, Spring CM, Jin JW, Yang H, Neves MAD, Chen P, Yang Y, Lei X, Chen Y, Gallant RC, Xu M, Zhang H, Song J, Ke P, Zhang D, Carrim N, Yu SY, Zhu G, She YM, Cyr T, Fu W, Liu G, Connelly PW, Rand ML, Adeli K, Freedman J, Lee JE, Tso P, Marchese P, Davidson WS, Jackson SP, Zhu C, Ruggeri ZM, Ni H. Xu XR, et al. Among authors: lei x. Nat Commun. 2018 Sep 6;9(1):3608. doi: 10.1038/s41467-018-05806-0. Nat Commun. 2018. PMID: 30190457 Free PMC article.
The integrin PSI domain has an endogenous thiol isomerase function and is a novel target for antiplatelet therapy.
Zhu G, Zhang Q, Reddy EC, Carrim N, Chen Y, Xu XR, Xu M, Wang Y, Hou Y, Ma L, Li Y, Rui M, Petruzziello-Pellegrini TN, Lavalle C, Stratton TW, Lei X, Adili R, Chen P, Zhu C, Wilkins JA, Hynes RO, Freedman J, Ni H. Zhu G, et al. Among authors: lei x. Blood. 2017 Mar 30;129(13):1840-1854. doi: 10.1182/blood-2016-07-729400. Epub 2017 Jan 25. Blood. 2017. PMID: 28122739 Free PMC article.
In vitro assessment and phase I randomized clinical trial of anfibatide a snake venom derived anti-thrombotic agent targeting human platelet GPIbα.
Li BX, Dai X, Xu XR, Adili R, Neves MAD, Lei X, Shen C, Zhu G, Wang Y, Zhou H, Hou Y, Ni T, Pasman Y, Yang Z, Qian F, Zhao Y, Gao Y, Liu J, Teng M, Marshall AH, Cerenzia EG, Li ML, Ni H. Li BX, et al. Among authors: lei x. Sci Rep. 2021 Jun 3;11(1):11663. doi: 10.1038/s41598-021-91165-8. Sci Rep. 2021. PMID: 34083615 Free PMC article. Clinical Trial.
4,431 results