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Diabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques.
Natunen T, Martiskainen H, Marttinen M, Gabbouj S, Koivisto H, Kemppainen S, Kaipainen S, Takalo M, Svobodová H, Leppänen L, Kemiläinen B, Ryhänen S, Kuulasmaa T, Rahunen E, Juutinen S, Mäkinen P, Miettinen P, Rauramaa T, Pihlajamäki J, Haapasalo A, Leinonen V, Tanila H, Hiltunen M. Natunen T, et al. Among authors: leinonen v. Mol Neurodegener. 2020 Nov 10;15(1):66. doi: 10.1186/s13024-020-00415-2. Mol Neurodegener. 2020. PMID: 33168021 Free PMC article.
Amyloid and tau proteins in cortical brain biopsy and Alzheimer's disease.
Leinonen V, Koivisto AM, Savolainen S, Rummukainen J, Tamminen JN, Tillgren T, Vainikka S, Pyykkö OT, Mölsä J, Fraunberg M, Pirttilä T, Jääskeläinen JE, Soininen H, Rinne J, Alafuzoff I. Leinonen V, et al. Ann Neurol. 2010 Oct;68(4):446-53. doi: 10.1002/ana.22100. Ann Neurol. 2010. PMID: 20976765
CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings.
Seppälä TT, Nerg O, Koivisto AM, Rummukainen J, Puli L, Zetterberg H, Pyykkö OT, Helisalmi S, Alafuzoff I, Hiltunen M, Jääskeläinen JE, Rinne J, Soininen H, Leinonen V, Herukka SK. Seppälä TT, et al. Among authors: leinonen v. Neurology. 2012 May 15;78(20):1568-75. doi: 10.1212/WNL.0b013e3182563bd0. Epub 2012 Apr 18. Neurology. 2012. PMID: 22517093
APOE4 predicts amyloid-β in cortical brain biopsy but not idiopathic normal pressure hydrocephalus.
Pyykkö OT, Helisalmi S, Koivisto AM, Mölsä JA, Rummukainen J, Nerg O, Alafuzoff I, Savolainen S, Soininen H, Jääskeläinen JE, Rinne J, Leinonen V, Hiltunen M. Pyykkö OT, et al. Among authors: leinonen v. J Neurol Neurosurg Psychiatry. 2012 Nov;83(11):1119-24. doi: 10.1136/jnnp-2011-303849. Epub 2012 Sep 6. J Neurol Neurosurg Psychiatry. 2012. PMID: 22955176
Effects of NR1H3 genetic variation on the expression of liver X receptor α and the progression of Alzheimer's disease.
Natunen T, Martiskainen H, Sarajärvi T, Helisalmi S, Pursiheimo JP, Viswanathan J, Laitinen M, Mäkinen P, Kauppinen T, Rauramaa T, Leinonen V, Alafuzoff I, Haapasalo A, Soininen H, Hiltunen M. Natunen T, et al. Among authors: leinonen v. PLoS One. 2013 Nov 20;8(11):e80700. doi: 10.1371/journal.pone.0080700. eCollection 2013. PLoS One. 2013. PMID: 24278306 Free PMC article.
Cerebrospinal fluid biomarker and brain biopsy findings in idiopathic normal pressure hydrocephalus.
Pyykkö OT, Lumela M, Rummukainen J, Nerg O, Seppälä TT, Herukka SK, Koivisto AM, Alafuzoff I, Puli L, Savolainen S, Soininen H, Jääskeläinen JE, Hiltunen M, Zetterberg H, Leinonen V. Pyykkö OT, et al. Among authors: leinonen v. PLoS One. 2014 Mar 17;9(3):e91974. doi: 10.1371/journal.pone.0091974. eCollection 2014. PLoS One. 2014. PMID: 24638077 Free PMC article.
High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status.
Takalo M, Haapasalo A, Martiskainen H, Kurkinen KM, Koivisto H, Miettinen P, Khandelwal VK, Kemppainen S, Kaminska D, Mäkinen P, Leinonen V, Pihlajamäki J, Soininen H, Laakso M, Tanila H, Hiltunen M. Takalo M, et al. Among authors: leinonen v. J Nutr Biochem. 2014 Jun;25(6):634-41. doi: 10.1016/j.jnutbio.2014.02.003. Epub 2014 Mar 12. J Nutr Biochem. 2014. PMID: 24746833
Effects of Alzheimer's disease-associated risk loci on cerebrospinal fluid biomarkers and disease progression: a polygenic risk score approach.
Martiskainen H, Helisalmi S, Viswanathan J, Kurki M, Hall A, Herukka SK, Sarajärvi T, Natunen T, Kurkinen KM, Huovinen J, Mäkinen P, Laitinen M, Koivisto AM, Mattila KM, Lehtimäki T, Remes AM, Leinonen V, Haapasalo A, Soininen H, Hiltunen M. Martiskainen H, et al. Among authors: leinonen v. J Alzheimers Dis. 2015;43(2):565-73. doi: 10.3233/JAD-140777. J Alzheimers Dis. 2015. PMID: 25096612
160 results