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Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase.
Achan V, Broadhead M, Malaki M, Whitley G, Leiper J, MacAllister R, Vallance P. Achan V, et al. Among authors: leiper j. Arterioscler Thromb Vasc Biol. 2003 Aug 1;23(8):1455-9. doi: 10.1161/01.ATV.0000081742.92006.59. Epub 2003 Jun 12. Arterioscler Thromb Vasc Biol. 2003. PMID: 12805079 Clinical Trial.
S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase.
Leiper J, Murray-Rust J, McDonald N, Vallance P. Leiper J, et al. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13527-32. doi: 10.1073/pnas.212269799. Epub 2002 Oct 7. Proc Natl Acad Sci U S A. 2002. PMID: 12370443 Free PMC article.
We recently solved the crystal structure of a bacterial DDAH and identified a Cys-His-Glu catalytic triad [Murray-Rust, J., Leiper, J. M., McAlister, M., Phelan, J., Tilley, S., Santa Maria, J., Vallance, P. & McDonald, N. (2001) Nat. ...
We recently solved the crystal structure of a bacterial DDAH and identified a Cys-His-Glu catalytic triad [Murray-Rust, J., Leiper …
Blocking NO synthesis: how, where and why?
Vallance P, Leiper J. Vallance P, et al. Among authors: leiper j. Nat Rev Drug Discov. 2002 Dec;1(12):939-50. doi: 10.1038/nrd960. Nat Rev Drug Discov. 2002. PMID: 12461516 Review.
184 results