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Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis.
Maddali MV, Churpek M, Pham T, Rezoagli E, Zhuo H, Zhao W, He J, Delucchi KL, Wang C, Wickersham N, McNeil JB, Jauregui A, Ke S, Vessel K, Gomez A, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Liu KD, Matthay MA, Ware LB, Laffey JG, Bellani G, Calfee CS, Sinha P; LUNG SAFE Investigators and the ESICM Trials Group. Maddali MV, et al. Among authors: leligdowicz a. Lancet Respir Med. 2022 Apr;10(4):367-377. doi: 10.1016/S2213-2600(21)00461-6. Epub 2022 Jan 10. Lancet Respir Med. 2022. PMID: 35026177 Free PMC article.
AIMing Immunomodulation Therapy at Sepsis.
Leligdowicz A, Matthay MA. Leligdowicz A, et al. Am J Respir Cell Mol Biol. 2019 Mar;60(3):253-254. doi: 10.1165/rcmb.2018-0338ED. Am J Respir Cell Mol Biol. 2019. PMID: 30365342 No abstract available.
The ex vivo perfused human lung is resistant to injury by high-dose S. pneumoniae bacteremia.
Ross JT, Nesseler N, Leligdowicz A, Zemans RL, Mahida RY, Minus E, Langelier C, Gotts JE, Matthay MA. Ross JT, et al. Among authors: leligdowicz a. Am J Physiol Lung Cell Mol Physiol. 2020 Aug 1;319(2):L218-L227. doi: 10.1152/ajplung.00053.2020. Epub 2020 Jun 10. Am J Physiol Lung Cell Mol Physiol. 2020. PMID: 32519893 Free PMC article.
Biological Mechanisms of COVID-19 Acute Respiratory Distress Syndrome.
Matthay MA, Leligdowicz A, Liu KD. Matthay MA, et al. Among authors: leligdowicz a. Am J Respir Crit Care Med. 2020 Dec 1;202(11):1489-1491. doi: 10.1164/rccm.202009-3629ED. Am J Respir Crit Care Med. 2020. PMID: 32997945 Free PMC article. No abstract available.
Using best subset regression to identify clinical characteristics and biomarkers associated with sepsis-associated acute kidney injury.
Kwong YD, Mehta KM, Miaskowski C, Zhuo H, Yee K, Jauregui A, Ke S, Deiss T, Abbott J, Kangelaris KN, Sinha P, Hendrickson C, Gomez A, Leligdowicz A, Matthay MA, Calfee CS, Liu KD. Kwong YD, et al. Among authors: leligdowicz a. Am J Physiol Renal Physiol. 2020 Dec 1;319(6):F979-F987. doi: 10.1152/ajprenal.00281.2020. Epub 2020 Oct 12. Am J Physiol Renal Physiol. 2020. PMID: 33044866 Free PMC article.
A neutrophil subset defined by intracellular olfactomedin 4 is associated with mortality in sepsis.
Kangelaris KN, Clemens R, Fang X, Jauregui A, Liu T, Vessel K, Deiss T, Sinha P, Leligdowicz A, Liu KD, Zhuo H, Alder MN, Wong HR, Calfee CS, Lowell C, Matthay MA. Kangelaris KN, et al. Among authors: leligdowicz a. Am J Physiol Lung Cell Mol Physiol. 2021 May 1;320(5):L892-L902. doi: 10.1152/ajplung.00090.2020. Epub 2020 Dec 23. Am J Physiol Lung Cell Mol Physiol. 2021. PMID: 33355521 Free PMC article. Clinical Trial.
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