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nsP4 Is a Major Determinant of Alphavirus Replicase Activity and Template Selectivity.
J Virol. 2021 Sep 27;95(20):e0035521. doi: 10.1128/JVI.00355-21. Epub 2021 Jul 28.
J Virol. 2021.
PMID: 34319783
Free PMC article.
Cross-utilisation of template RNAs by alphavirus replicases.
Lello LS, Utt A, Bartholomeeusen K, Wang S, Rausalu K, Kendall C, Coppens S, Fragkoudis R, Tuplin A, Alphey L, Ariën KK, Merits A.
Lello LS, et al.
PLoS Pathog. 2020 Sep 4;16(9):e1008825. doi: 10.1371/journal.ppat.1008825. eCollection 2020 Sep.
PLoS Pathog. 2020.
PMID: 32886709
Free PMC article.
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Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold.
Tan YB, Lello LS, Liu X, Law YS, Kang C, Lescar J, Zheng J, Merits A, Luo D.
Tan YB, et al. Among authors: lello ls.
Nucleic Acids Res. 2022 Jan 25;50(2):1000-1016. doi: 10.1093/nar/gkab1302.
Nucleic Acids Res. 2022.
PMID: 35037043
Free PMC article.
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Bortezomib inhibits chikungunya virus replication by interfering with viral protein synthesis.
Kaur P, Lello LS, Utt A, Dutta SK, Merits A, Chu JJH.
Kaur P, et al. Among authors: lello ls.
PLoS Negl Trop Dis. 2020 May 29;14(5):e0008336. doi: 10.1371/journal.pntd.0008336. eCollection 2020 May.
PLoS Negl Trop Dis. 2020.
PMID: 32469886
Free PMC article.
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Synergistic Interferon-Alpha-Based Combinations for Treatment of SARS-CoV-2 and Other Viral Infections.
Ianevski A, Yao R, Zusinaite E, Lello LS, Wang S, Jo E, Yang J, Ravlo E, Wang W, Lysvand H, Løseth K, Oksenych V, Tenson T, Windisch MP, Poranen MM, Nieminen AI, Nordbø SA, Fenstad MH, Grødeland G, Aukrust P, Trøseid M, Kantele A, Lastauskienė E, Vitkauskienė A, Legrand N, Merits A, Bjørås M, Kainov DE.
Ianevski A, et al. Among authors: lello ls.
Viruses. 2021 Dec 11;13(12):2489. doi: 10.3390/v13122489.
Viruses. 2021.
PMID: 34960758
Free PMC article.
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A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research.
Rihn SJ, Merits A, Bakshi S, Turnbull ML, Wickenhagen A, Alexander AJT, Baillie C, Brennan B, Brown F, Brunker K, Bryden SR, Burness KA, Carmichael S, Cole SJ, Cowton VM, Davies P, Davis C, De Lorenzo G, Donald CL, Dorward M, Dunlop JI, Elliott M, Fares M, da Silva Filipe A, Freitas JR, Furnon W, Gestuveo RJ, Geyer A, Giesel D, Goldfarb DM, Goodman N, Gunson R, Hastie CJ, Herder V, Hughes J, Johnson C, Johnson N, Kohl A, Kerr K, Leech H, Lello LS, Li K, Lieber G, Liu X, Lingala R, Loney C, Mair D, McElwee MJ, McFarlane S, Nichols J, Nomikou K, Orr A, Orton RJ, Palmarini M, Parr YA, Pinto RM, Raggett S, Reid E, Robertson DL, Royle J, Cameron-Ruiz N, Shepherd JG, Smollett K, Stewart DG, Stewart M, Sugrue E, Szemiel AM, Taggart A, Thomson EC, Tong L, Torrie LS, Toth R, Varjak M, Wang S, Wilkinson SG, Wyatt PG, Zusinaite E, Alessi DR, Patel AH, Zaid A, Wilson SJ, Mahalingam S.
Rihn SJ, et al. Among authors: lello ls.
PLoS Biol. 2021 Feb 25;19(2):e3001091. doi: 10.1371/journal.pbio.3001091. eCollection 2021 Feb.
PLoS Biol. 2021.
PMID: 33630831
Free PMC article.
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Bovine colostrum-derived antibodies against SARS-CoV-2 show great potential to serve as prophylactic agents.
Kangro K, Kurašin M, Gildemann K, Sankovski E, Žusinaite E, Lello LS, Pert R, Kavak A, Poikalainen V, Lepasalu L, Kuusk M, Pau R, Piiskop S, Rom S, Oltjer R, Tiirik K, Kogermann K, Plaas M, Tiirats T, Aasmäe B, Plaas M, Mumm K, Krinka D, Talpsep E, Kadaja M, Gerhold JM, Planken A, Tover A, Merits A, Männik A, Ustav M Jr, Ustav M.
Kangro K, et al. Among authors: lello ls.
PLoS One. 2022 Jun 10;17(6):e0268806. doi: 10.1371/journal.pone.0268806. eCollection 2022.
PLoS One. 2022.
PMID: 35687549
Free PMC article.
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Activity, Template Preference, and Compatibility of Components of RNA Replicase of Eastern Equine Encephalitis Virus.
Lello LS, Miilimäe A, Cherkashchenko L, Omler A, Skilton R, Ireland R, Ulaeto D, Merits A.
Lello LS, et al.
J Virol. 2023 Jan 31;97(1):e0136822. doi: 10.1128/jvi.01368-22. Epub 2022 Dec 19.
J Virol. 2023.
PMID: 36533950
Free PMC article.
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