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Design and Synthesis of Multi-Functional Ligands through Hantzsch Reaction: Targeting Ca2+ Channels, Activating Nrf2 and Possessing Cathepsin S Inhibitory, and Antioxidant Properties.
Pachón-Angona I, Bernard PJ, Simakov A, Maj M, Jozwiak K, Novotna A, Lemke C, Gütschow M, Martin H, Oset-Gasque MJ, Contelles JM, Ismaili L. Pachón-Angona I, et al. Among authors: lemke c. Pharmaceutics. 2024 Jan 17;16(1):121. doi: 10.3390/pharmaceutics16010121. Pharmaceutics. 2024. PMID: 38258131 Free PMC article.
Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation.
Babbe H, Sundberg TB, Tichenor M, Seierstad M, Bacani G, Berstler J, Chai W, Chang L, Chung M, Coe K, Collins B, Finley M, Guletsky A, Lemke CT, Mak PA, Mathur A, Mercado-Marin EV, Metkar S, Raymond DD, Rives ML, Rizzolio M, Shaffer PL, Smith R, Smith J, Steele R, Steffens H, Suarez J, Tian G, Majewski N, Volak LP, Wei J, Desai PT, Ong LL, Koudriakova T, Goldberg SD, Hirst G, Kaushik VK, Ort T, Seth N, Graham DB, Plevy S, Venable JD, Xavier RJ, Towne JE. Babbe H, et al. Among authors: lemke ct. Proc Natl Acad Sci U S A. 2024 Jan 2;121(1):e2307086120. doi: 10.1073/pnas.2307086120. Epub 2023 Dec 26. Proc Natl Acad Sci U S A. 2024. PMID: 38147543
Adaptive constraints at the range edge of a widespread and expanding invasive plant.
Fletcher RA, Atwater DZ, Haak DC, Bagavathiannan MV, DiTommaso A, Lehnhoff E, Paterson AH, Auckland S, Govindasamy P, Lemke C, Morris E, Rainville L, Barney JN. Fletcher RA, et al. Among authors: lemke c. AoB Plants. 2023 Nov 5;15(6):plad070. doi: 10.1093/aobpla/plad070. eCollection 2023 Dec. AoB Plants. 2023. PMID: 38028747 Free PMC article.
Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists.
Orsi DL, Ferrara SJ, Siegel S, Friberg A, Bouché L, Pook E, Lienau P, Bluck JP, Lemke CT, Akcay G, Stellfeld T, Meyer H, Pütter V, Holton SJ, Korr D, Jerchel-Furau I, Pantelidou C, Strathdee CA, Meyerson M, Eis K, Goldstein JT. Orsi DL, et al. Among authors: lemke ct. Bioorg Med Chem. 2023 Jan 15;78:117130. doi: 10.1016/j.bmc.2022.117130. Epub 2022 Dec 13. Bioorg Med Chem. 2023. PMID: 36542958 Free article.
152 results