Leo G - Search Results

1

(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells.

Ho CY, Ludovici DW, Maharoof US, Mei J, Sechler JL, Tuman RW, Strobel ED, Andraka L, Yen HK, Leo G, Li J, Almond H, Lu H, DeVine A, Tominovich RM, Baker J, Emanuel S, Gruninger RH, Middleton SA, Johnson DL, Galemmo RA Jr. Ho CY, et al. Among authors: leo g. J Med Chem. 2005 Dec 29;48(26):8163-73. doi: 10.1021/jm050680m. J Med Chem. 2005. PMID: 16366598

2

N-glucuronidation of the platelet-derived growth factor receptor tyrosine kinase inhibitor 6,7-(dimethoxy-2,4-dihydroindeno[1,2-C]pyrazol-3-yl)-(3-fluoro-phenyl)-amine by human UDP-glucuronosyltransferases.

Yan Z, Caldwell GW, Gauthier D, Leo GC, Mei J, Ho CY, Jones WJ, Masucci JA, Tuman RW, Galemmo RA Jr, Johnson DL. Yan Z, et al. Among authors: leo gc. Drug Metab Dispos. 2006 May;34(5):748-55. doi: 10.1124/dmd.106.009274. Epub 2006 Feb 2. Drug Metab Dispos. 2006. PMID: 16455802

3

1,2,3,4-Tetrahydroquinoline-containing alphaVbeta3 integrin antagonists with enhanced oral bioavailability.

Ghosh S, Santulli RJ, Kinney WA, Decorte BL, Liu L, Lewis JM, Proost JC, Leo GC, Masucci J, Hageman WE, Thompson AS, Chen I, Kawahama R, Tuman RW, Galemmo RA Jr, Johnson DL, Damiano BP, Maryanoff BE. Ghosh S, et al. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5937-41. doi: 10.1016/j.bmcl.2004.08.067. Bioorg Med Chem Lett. 2004. PMID: 15501072

4

Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo [4,5,1-jk][1,4]benzodiazepin-2(1H)-one (TIBO) derivatives. 3.

Breslin HJ, Kukla MJ, Ludovici DW, Mohrbacher R, Ho W, Miranda M, Rodgers JD, Hitchens TK, Leo G, Gauthier DA, et al. Breslin HJ, et al. Among authors: leo g. J Med Chem. 1995 Mar 3;38(5):771-93. doi: 10.1021/jm00005a005. J Med Chem. 1995. PMID: 7877143

5

Thrombin receptor-activating peptides (TRAPs): investigation of bioactive conformations via structure-activity, spectroscopic, and computational studies.

Ceruso MA, McComsey DF, Leo GC, Andrade-Gordon P, Addo MF, Scarborough RM, Oksenberg D, Maryanoff BE. Ceruso MA, et al. Among authors: leo gc. Bioorg Med Chem. 1999 Nov;7(11):2353-71. doi: 10.1016/s0968-0896(99)00180-7. Bioorg Med Chem. 1999. PMID: 10632045

6

A thiocarbamate inhibitor of endothelial lipase raises HDL cholesterol levels in mice.

Greco MN, Connelly MA, Leo GC, Olson MW, Powell E, Huang Z, Hawkins M, Smith C, Schalk-Hihi C, Darrow AL, Xin H, Lang W, Damiano BP, Hlasta DJ. Greco MN, et al. Among authors: leo gc. Bioorg Med Chem Lett. 2013 May 1;23(9):2595-7. doi: 10.1016/j.bmcl.2013.02.113. Epub 2013 Mar 7. Bioorg Med Chem Lett. 2013. PMID: 23528297

7

Biotransformation of geldanamycin and 17-allylamino-17-demethoxygeldanamycin by human liver microsomes: reductive versus oxidative metabolism and implications.

Lang W, Caldwell GW, Li J, Leo GC, Jones WJ, Masucci JA. Lang W, et al. Drug Metab Dispos. 2007 Jan;35(1):21-9. doi: 10.1124/dmd.106.009639. Epub 2006 Sep 29. Drug Metab Dispos. 2007. PMID: 17012542

8

Design, synthesis, and conformational analysis of eight-membered cyclic peptidomimetics prepared using ring closing metathesis.

Creighton CJ, Leo GC, Du Y, Reitz AB. Creighton CJ, et al. Bioorg Med Chem. 2004 Aug 15;12(16):4375-85. doi: 10.1016/j.bmc.2004.06.015. Bioorg Med Chem. 2004. PMID: 15265489

9

Synthesis of macrocycles via cobalt-mediated [2 + 2 + 2] cycloadditions.

Boñaga LV, Zhang HC, Moretto AF, Ye H, Gauthier DA, Li J, Leo GC, Maryanoff BE. Boñaga LV, et al. J Am Chem Soc. 2005 Mar 16;127(10):3473-85. doi: 10.1021/ja045001w. J Am Chem Soc. 2005. PMID: 15755167

10

Protein structure determination using a combination of comparative modeling and NMR spectroscopy. Application to the response regulator protein, Spo0F.

Podlogar BL, Leo GC, McDonnell PA, Loughney DA, Caldwell GW, Barrett JF. Podlogar BL, et al. Among authors: leo gc. J Med Chem. 1997 Oct 10;40(21):3453-5. doi: 10.1021/jm970156i. J Med Chem. 1997. PMID: 9341920

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