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Nature-Inspired Gallinamides Are Potent Antischistosomal Agents: Inhibition of the Cathepsin B1 Protease Target and Binding Mode Analysis.
Spiwoková P, Horn M, Fanfrlík J, Jílková A, Fajtová P, Leontovyč A, Houštecká R, Bieliková L, Brynda J, Chanová M, Mertlíková-Kaiserová H, Caro-Diaz EJE, Almaliti J, El-Sakkary N, Gerwick WH, Caffrey CR, Mareš M. Spiwoková P, et al. Among authors: leontovyc a. ACS Infect Dis. 2024 May 17. doi: 10.1021/acsinfecdis.3c00589. Online ahead of print. ACS Infect Dis. 2024. PMID: 38757505
SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties.
Leontovyč A, Ulrychová L, O'Donoghue AJ, Vondrášek J, Marešová L, Hubálek M, Fajtová P, Chanová M, Jiang Z, Craik CS, Caffrey CR, Mareš M, Dvořák J, Horn M. Leontovyč A, et al. PLoS Negl Trop Dis. 2018 Apr 20;12(4):e0006446. doi: 10.1371/journal.pntd.0006446. eCollection 2018 Apr. PLoS Negl Trop Dis. 2018. PMID: 29677188 Free PMC article.