Leroy C - Search Results

1

Activation of IGF1R/p110β/AKT/mTOR confers resistance to α-specific PI3K inhibition.

Leroy C, Ramos P, Cornille K, Bonenfant D, Fritsch C, Voshol H, Bentires-Alj M. Leroy C, et al. Breast Cancer Res. 2016 Apr 5;18(1):41. doi: 10.1186/s13058-016-0697-1. Breast Cancer Res. 2016. PMID: 27048245 Free PMC article.

2

Anticipating mechanisms of resistance to PI3K inhibition in breast cancer: a challenge in the era of precision medicine.

Leroy C, Amante RJ, Bentires-Alj M. Leroy C, et al. Biochem Soc Trans. 2014 Aug;42(4):733-41. doi: 10.1042/BST20140034. Biochem Soc Trans. 2014. PMID: 25109950 Review.

3

Tyrosine phosphatase SHP2 increases cell motility in triple-negative breast cancer through the activation of SRC-family kinases.

Sausgruber N, Coissieux MM, Britschgi A, Wyckoff J, Aceto N, Leroy C, Stadler MB, Voshol H, Bonenfant D, Bentires-Alj M. Sausgruber N, et al. Among authors: leroy c. Oncogene. 2015 Apr 23;34(17):2272-8. doi: 10.1038/onc.2014.170. Epub 2014 Jun 16. Oncogene. 2015. PMID: 24931162

4

CUB-domain-containing protein 1 overexpression in solid cancers promotes cancer cell growth by activating Src family kinases.

Leroy C, Shen Q, Strande V, Meyer R, McLaughlin ME, Lezan E, Bentires-Alj M, Voshol H, Bonenfant D, Alex Gaither L. Leroy C, et al. Oncogene. 2015 Oct 29;34(44):5593-8. doi: 10.1038/onc.2015.19. Epub 2015 Mar 2. Oncogene. 2015. PMID: 25728678 Free PMC article.

5

The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα.

Britschgi A, Duss S, Kim S, Couto JP, Brinkhaus H, Koren S, De Silva D, Mertz KD, Kaup D, Varga Z, Voshol H, Vissieres A, Leroy C, Roloff T, Stadler MB, Scheel CH, Miraglia LJ, Orth AP, Bonamy GM, Reddy VA, Bentires-Alj M. Britschgi A, et al. Among authors: leroy c. Nature. 2017 Jan 26;541(7638):541-545. doi: 10.1038/nature20829. Epub 2017 Jan 9. Nature. 2017. PMID: 28068668 Free PMC article.

6

Expression of PIK3CA mutant E545K in the mammary gland induces heterogeneous tumors but is less potent than mutant H1047R.

Meyer DS, Koren S, Leroy C, Brinkhaus H, Müller U, Klebba I, Müller M, Cardiff RD, Bentires-Alj M. Meyer DS, et al. Among authors: leroy c. Oncogenesis. 2013 Sep 30;2(9):e74. doi: 10.1038/oncsis.2013.38. Oncogenesis. 2013. PMID: 24080956 Free PMC article.

7

Inhibition of DDR1-BCR signalling by nilotinib as a new therapeutic strategy for metastatic colorectal cancer.

Jeitany M, Leroy C, Tosti P, Lafitte M, Le Guet J, Simon V, Bonenfant D, Robert B, Grillet F, Mollevi C, El Messaoudi S, Otandault A, Canterel-Thouennon L, Busson M, Thierry AR, Martineau P, Pannequin J, Roche S, Sirvent A. Jeitany M, et al. Among authors: leroy c. EMBO Mol Med. 2018 Apr;10(4):e7918. doi: 10.15252/emmm.201707918. EMBO Mol Med. 2018. PMID: 29438985 Free PMC article.

8

YES oncogenic activity is specified by its SH4 domain and regulates RAS/MAPK signaling in colon carcinoma cells.

Dubois F, Leroy C, Simon V, Benistant C, Roche S. Dubois F, et al. Among authors: leroy c. Am J Cancer Res. 2015 May 15;5(6):1972-87. eCollection 2015. Am J Cancer Res. 2015. PMID: 26269757 Free PMC article.

9

Evidence that resistance to nilotinib may be due to BCR-ABL, Pgp, or Src kinase overexpression.

Mahon FX, Hayette S, Lagarde V, Belloc F, Turcq B, Nicolini F, Belanger C, Manley PW, Leroy C, Etienne G, Roche S, Pasquet JM. Mahon FX, et al. Among authors: leroy c. Cancer Res. 2008 Dec 1;68(23):9809-16. doi: 10.1158/0008-5472.CAN-08-1008. Cancer Res. 2008. PMID: 19047160

10

SLAP displays tumour suppressor functions in colorectal cancer via destabilization of the SRC substrate EPHA2.

Naudin C, Sirvent A, Leroy C, Larive R, Simon V, Pannequin J, Bourgaux JF, Pierre J, Robert B, Hollande F, Roche S. Naudin C, et al. Among authors: leroy c. Nat Commun. 2014;5:3159. doi: 10.1038/ncomms4159. Nat Commun. 2014. PMID: 24457997 Free article.

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