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Suppressive myeloid cells are expanded by biliary tract cancer-derived cytokines in vitro and associate with aggressive disease.
Ware MB, Zaidi MY, Yang J, Turgeon MK, Krasinskas A, Mace TA, Keenan K, Farren MR, Ruggieri AN, Li Y, Zhang C, Chen Z, Young GS, Elnaggar O, Che Z, Maithel SK, Bekaii-Saab T, El-Rayes B, Lesinski GB. Ware MB, et al. Among authors: lesinski gb. Br J Cancer. 2020 Oct;123(9):1377-1386. doi: 10.1038/s41416-020-1018-0. Epub 2020 Aug 4. Br J Cancer. 2020. PMID: 32747748 Free PMC article.
A dose-finding and pharmacodynamic study of bortezomib in combination with weekly paclitaxel in patients with advanced solid tumors.
Ramaswamy B, Bekaii-Saab T, Schaaf LJ, Lesinski GB, Lucas DM, Young DC, Ruppert AS, Byrd JC, Culler K, Wilkins D, Wright JJ, Grever MR, Shapiro CL. Ramaswamy B, et al. Among authors: lesinski gb. Cancer Chemother Pharmacol. 2010 May;66(1):151-8. doi: 10.1007/s00280-009-1145-z. Epub 2009 Sep 23. Cancer Chemother Pharmacol. 2010. PMID: 19774377 Free PMC article. Clinical Trial.
Interleukin-29 binds to melanoma cells inducing Jak-STAT signal transduction and apoptosis.
Guenterberg KD, Grignol VP, Raig ET, Zimmerer JM, Chan AN, Blaskovits FM, Young GS, Nuovo GJ, Mundy BL, Lesinski GB, Carson WE 3rd. Guenterberg KD, et al. Among authors: lesinski gb. Mol Cancer Ther. 2010 Feb;9(2):510-20. doi: 10.1158/1535-7163.MCT-09-0461. Epub 2010 Jan 26. Mol Cancer Ther. 2010. PMID: 20103601 Free PMC article.
The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity.
Bill MA, Fuchs JR, Li C, Yui J, Bakan C, Benson DM Jr, Schwartz EB, Abdelhamid D, Lin J, Hoyt DG, Fossey SL, Young GS, Carson WE 3rd, Li PK, Lesinski GB. Bill MA, et al. Among authors: lesinski gb. Mol Cancer. 2010 Jun 25;9:165. doi: 10.1186/1476-4598-9-165. Mol Cancer. 2010. PMID: 20576164 Free PMC article.
Distinct myeloid suppressor cell subsets correlate with plasma IL-6 and IL-10 and reduced interferon-alpha signaling in CD4⁺ T cells from patients with GI malignancy.
Mundy-Bosse BL, Young GS, Bauer T, Binkley E, Bloomston M, Bill MA, Bekaii-Saab T, Carson WE 3rd, Lesinski GB. Mundy-Bosse BL, et al. Among authors: lesinski gb. Cancer Immunol Immunother. 2011 Sep;60(9):1269-79. doi: 10.1007/s00262-011-1029-z. Epub 2011 May 21. Cancer Immunol Immunother. 2011. PMID: 21604071 Free PMC article.
Myeloid-derived suppressor cell inhibition of the IFN response in tumor-bearing mice.
Mundy-Bosse BL, Lesinski GB, Jaime-Ramirez AC, Benninger K, Khan M, Kuppusamy P, Guenterberg K, Kondadasula SV, Chaudhury AR, La Perle KM, Kreiner M, Young G, Guttridge DC, Carson WE 3rd. Mundy-Bosse BL, et al. Among authors: lesinski gb. Cancer Res. 2011 Aug 1;71(15):5101-10. doi: 10.1158/0008-5472.CAN-10-2670. Epub 2011 Jun 16. Cancer Res. 2011. PMID: 21680779 Free PMC article.
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