Lesourne R - Search Results

1

THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1.

Choi S, Warzecha C, Zvezdova E, Lee J, Argenty J, Lesourne R, Aravind L, Love PE. Choi S, et al. Among authors: lesourne r. Nat Immunol. 2017 Apr;18(4):433-441. doi: 10.1038/ni.3692. Epub 2017 Feb 27. Nat Immunol. 2017. PMID: 28250424 Free PMC article.

2

Tyrosine phosphorylation controls nuclear localization and transcriptional activity of Ssdp1 in mammalian cells.

Dey-Guha I, Malik N, Lesourne R, Love PE, Westphal H. Dey-Guha I, et al. Among authors: lesourne r. J Cell Biochem. 2008 Apr 15;103(6):1856-65. doi: 10.1002/jcb.21576. J Cell Biochem. 2008. PMID: 18080319

3

Themis, a T cell-specific protein important for late thymocyte development.

Lesourne R, Uehara S, Lee J, Song KD, Li L, Pinkhasov J, Zhang Y, Weng NP, Wildt KF, Wang L, Bosselut R, Love PE. Lesourne R, et al. Nat Immunol. 2009 Aug;10(8):840-7. doi: 10.1038/ni.1768. Epub 2009 Jul 13. Nat Immunol. 2009. PMID: 19597498 Free PMC article.

4

Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function.

Lesourne R, Zvezdova E, Song KD, El-Khoury D, Uehara S, Barr VA, Samelson LE, Love PE. Lesourne R, et al. J Immunol. 2012 Aug 1;189(3):1154-61. doi: 10.4049/jimmunol.1200123. Epub 2012 Jun 25. J Immunol. 2012. PMID: 22732588 Free PMC article.

5

Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease.

Hwang S, Song KD, Lesourne R, Lee J, Pinkhasov J, Li L, El-Khoury D, Love PE. Hwang S, et al. Among authors: lesourne r. J Exp Med. 2012 Sep 24;209(10):1781-95. doi: 10.1084/jem.20120058. Epub 2012 Sep 3. J Exp Med. 2012. PMID: 22945921 Free PMC article.

6

Thpok-independent repression of Runx3 by Gata3 during CD4+ T-cell differentiation in the thymus.

Xiong Y, Castro E, Yagi R, Zhu J, Lesourne R, Love PE, Feigenbaum L, Bosselut R. Xiong Y, et al. Among authors: lesourne r. Eur J Immunol. 2013 Apr;43(4):918-28. doi: 10.1002/eji.201242944. Epub 2013 Feb 12. Eur J Immunol. 2013. PMID: 23310955 Free PMC article.

7

TCR ITAM multiplicity is required for the generation of follicular helper T-cells.

Hwang S, Palin AC, Li L, Song KD, Lee J, Herz J, Tubo N, Chu H, Pepper M, Lesourne R, Zvezdova E, Pinkhasov J, Jenkins MK, McGavern D, Love PE. Hwang S, et al. Among authors: lesourne r. Nat Commun. 2015 May 11;6:6982. doi: 10.1038/ncomms7982. Nat Commun. 2015. PMID: 25959494 Free PMC article.

8

An Epistatic Interaction between Themis1 and Vav1 Modulates Regulatory T Cell Function and Inflammatory Bowel Disease Development.

Pedros C, Gaud G, Bernard I, Kassem S, Chabod M, Lagrange D, Andréoletti O, Dejean AS, Lesourne R, Fournié GJ, Saoudi A. Pedros C, et al. Among authors: lesourne r. J Immunol. 2015 Aug 15;195(4):1608-16. doi: 10.4049/jimmunol.1402562. Epub 2015 Jul 10. J Immunol. 2015. PMID: 26163585

9

Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability.

Zvezdova E, Mikolajczak J, Garreau A, Marcellin M, Rigal L, Lee J, Choi S, Blaize G, Argenty J, Familiades J, Li L, Gonzalez de Peredo A, Burlet-Schiltz O, Love PE, Lesourne R. Zvezdova E, et al. Among authors: lesourne r. Sci Signal. 2016 May 17;9(428):ra51. doi: 10.1126/scisignal.aad1576. Sci Signal. 2016. PMID: 27188442

10

Themis2 lowers the threshold for B cell activation during positive selection.

Cheng D, Deobagkar-Lele M, Zvezdova E, Choi S, Uehara S, Baup D, Bennett SC, Bull KR, Crockford TL, Ferry H, Warzecha C, Marcellin M, de Peredo AG, Lesourne R, Anzilotti C, Love PE, Cornall RJ. Cheng D, et al. Among authors: lesourne r. Nat Immunol. 2017 Feb;18(2):205-213. doi: 10.1038/ni.3642. Epub 2016 Dec 19. Nat Immunol. 2017. PMID: 27992403

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