Lessene G - Search Results

1

Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL.

Murphy JM, Lucet IS, Hildebrand JM, Tanzer MC, Young SN, Sharma P, Lessene G, Alexander WS, Babon JJ, Silke J, Czabotar PE. Murphy JM, et al. Among authors: lessene g. Biochem J. 2014 Feb 1;457(3):369-77. doi: 10.1042/BJ20131270. Biochem J. 2014. PMID: 24219132

2

BCL-2 family antagonists for cancer therapy.

Lessene G, Czabotar PE, Colman PM. Lessene G, et al. Nat Rev Drug Discov. 2008 Dec;7(12):989-1000. doi: 10.1038/nrd2658. Nat Rev Drug Discov. 2008. PMID: 19043450 Review.

3

Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands.

Lee EF, Czabotar PE, Yang H, Sleebs BE, Lessene G, Colman PM, Smith BJ, Fairlie WD. Lee EF, et al. Among authors: lessene g. J Biol Chem. 2009 Oct 30;284(44):30508-17. doi: 10.1074/jbc.M109.040725. Epub 2009 Sep 2. J Biol Chem. 2009. PMID: 19726685 Free PMC article.

4

Bcl-2 family proteins as therapeutic targets.

Czabotar PE, Lessene G. Czabotar PE, et al. Among authors: lessene g. Curr Pharm Des. 2010;16(28):3132-48. doi: 10.2174/138161210793292429. Curr Pharm Des. 2010. PMID: 20687882 Review.

5

Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.

Sleebs BE, Czabotar PE, Fairbrother WJ, Fairlie WD, Flygare JA, Huang DC, Kersten WJ, Koehler MF, Lessene G, Lowes K, Parisot JP, Smith BJ, Smith ML, Souers AJ, Street IP, Yang H, Baell JB. Sleebs BE, et al. Among authors: lessene g. J Med Chem. 2011 Mar 24;54(6):1914-26. doi: 10.1021/jm101596e. Epub 2011 Mar 2. J Med Chem. 2011. PMID: 21366295

6

Structure-guided design of a selective BCL-X(L) inhibitor.

Lessene G, Czabotar PE, Sleebs BE, Zobel K, Lowes KN, Adams JM, Baell JB, Colman PM, Deshayes K, Fairbrother WJ, Flygare JA, Gibbons P, Kersten WJ, Kulasegaram S, Moss RM, Parisot JP, Smith BJ, Street IP, Yang H, Huang DC, Watson KG. Lessene G, et al. Nat Chem Biol. 2013 Jun;9(6):390-7. doi: 10.1038/nchembio.1246. Epub 2013 Apr 21. Nat Chem Biol. 2013. PMID: 23603658

7

Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.

Sleebs BE, Kersten WJ, Kulasegaram S, Nikolakopoulos G, Hatzis E, Moss RM, Parisot JP, Yang H, Czabotar PE, Fairlie WD, Lee EF, Adams JM, Chen L, van Delft MF, Lowes KN, Wei A, Huang DC, Colman PM, Street IP, Baell JB, Watson K, Lessene G. Sleebs BE, et al. Among authors: lessene g. J Med Chem. 2013 Jul 11;56(13):5514-40. doi: 10.1021/jm400556w. Epub 2013 Jun 26. J Med Chem. 2013. PMID: 23767404

8

Cell death and the mitochondria: therapeutic targeting of the BCL-2 family-driven pathway.

Roy MJ, Vom A, Czabotar PE, Lessene G. Roy MJ, et al. Among authors: lessene g. Br J Pharmacol. 2014 Apr;171(8):1973-87. doi: 10.1111/bph.12431. Br J Pharmacol. 2014. PMID: 24117105 Free PMC article.

9

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy.

Czabotar PE, Lessene G, Strasser A, Adams JM. Czabotar PE, et al. Among authors: lessene g. Nat Rev Mol Cell Biol. 2014 Jan;15(1):49-63. doi: 10.1038/nrm3722. Nat Rev Mol Cell Biol. 2014. PMID: 24355989 Review.

10

De-novo designed library of benzoylureas as inhibitors of BCL-XL: synthesis, structural and biochemical characterization.

Brady RM, Vom A, Roy MJ, Toovey N, Smith BJ, Moss RM, Hatzis E, Huang DC, Parisot JP, Yang H, Street IP, Colman PM, Czabotar PE, Baell JB, Lessene G. Brady RM, et al. Among authors: lessene g. J Med Chem. 2014 Feb 27;57(4):1323-43. doi: 10.1021/jm401948b. Epub 2014 Feb 5. J Med Chem. 2014. PMID: 24456288

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

85 results

Search Page