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Limited amounts of dendritic cells migrate into the T-cell area of lymph nodes but have high immune activating potential in melanoma patients.
Verdijk P, Aarntzen EH, Lesterhuis WJ, Boullart AC, Kok E, van Rossum MM, Strijk S, Eijckeler F, Bonenkamp JJ, Jacobs JF, Blokx W, Vankrieken JH, Joosten I, Boerman OC, Oyen WJ, Adema G, Punt CJ, Figdor CG, de Vries IJ. Verdijk P, et al. Among authors: lesterhuis wj. Clin Cancer Res. 2009 Apr 1;15(7):2531-40. doi: 10.1158/1078-0432.CCR-08-2729. Epub 2009 Mar 24. Clin Cancer Res. 2009. PMID: 19318472 Free article.
Cancer immunotherapy--revisited.
Lesterhuis WJ, Haanen JB, Punt CJ. Lesterhuis WJ, et al. Nat Rev Drug Discov. 2011 Aug 1;10(8):591-600. doi: 10.1038/nrd3500. Nat Rev Drug Discov. 2011. PMID: 21804596 Review.
Vaccination with mRNA-electroporated dendritic cells induces robust tumor antigen-specific CD4+ and CD8+ T cells responses in stage III and IV melanoma patients.
Aarntzen EH, Schreibelt G, Bol K, Lesterhuis WJ, Croockewit AJ, de Wilt JH, van Rossum MM, Blokx WA, Jacobs JF, Duiveman-de Boer T, Schuurhuis DH, Mus R, Thielemans K, de Vries IJ, Figdor CG, Punt CJ, Adema GJ. Aarntzen EH, et al. Among authors: lesterhuis wj. Clin Cancer Res. 2012 Oct 1;18(19):5460-70. doi: 10.1158/1078-0432.CCR-11-3368. Epub 2012 Aug 15. Clin Cancer Res. 2012. PMID: 22896657
Early identification of antigen-specific immune responses in vivo by [18F]-labeled 3'-fluoro-3'-deoxy-thymidine ([18F]FLT) PET imaging.
Aarntzen EH, Srinivas M, De Wilt JH, Jacobs JF, Lesterhuis WJ, Windhorst AD, Troost EG, Bonenkamp JJ, van Rossum MM, Blokx WA, Mus RD, Boerman OC, Punt CJ, Figdor CG, Oyen WJ, de Vries IJ. Aarntzen EH, et al. Among authors: lesterhuis wj. Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18396-9. doi: 10.1073/pnas.1113045108. Epub 2011 Oct 24. Proc Natl Acad Sci U S A. 2011. PMID: 22025695 Free PMC article.
Targeting CD4(+) T-helper cells improves the induction of antitumor responses in dendritic cell-based vaccination.
Aarntzen EH, De Vries IJ, Lesterhuis WJ, Schuurhuis D, Jacobs JF, Bol K, Schreibelt G, Mus R, De Wilt JH, Haanen JB, Schadendorf D, Croockewit A, Blokx WA, Van Rossum MM, Kwok WW, Adema GJ, Punt CJ, Figdor CG. Aarntzen EH, et al. Among authors: lesterhuis wj. Cancer Res. 2013 Jan 1;73(1):19-29. doi: 10.1158/0008-5472.CAN-12-1127. Epub 2012 Oct 18. Cancer Res. 2013. PMID: 23087058 Clinical Trial.
80 results