Leung D - Search Results

1

A brain detoxifying enzyme for organophosphorus nerve poisons.

Nomura DK, Leung D, Chiang KP, Quistad GB, Cravatt BF, Casida JE. Nomura DK, et al. Among authors: leung d. Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6195-200. doi: 10.1073/pnas.0501915102. Epub 2005 Apr 19. Proc Natl Acad Sci U S A. 2005. PMID: 15840715 Free PMC article.

2

Discovering potent and selective reversible inhibitors of enzymes in complex proteomes.

Leung D, Hardouin C, Boger DL, Cravatt BF. Leung D, et al. Nat Biotechnol. 2003 Jun;21(6):687-91. doi: 10.1038/nbt826. Epub 2003 May 12. Nat Biotechnol. 2003. PMID: 12740587

3

Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity.

Leung D, Du W, Hardouin C, Cheng H, Hwang I, Cravatt BF, Boger DL. Leung D, et al. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1423-8. doi: 10.1016/j.bmcl.2004.12.085. Bioorg Med Chem Lett. 2005. PMID: 15713400

4

Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids.

Leung D, Saghatelian A, Simon GM, Cravatt BF. Leung D, et al. Biochemistry. 2006 Apr 18;45(15):4720-6. doi: 10.1021/bi060163l. Biochemistry. 2006. PMID: 16605240 Free PMC article.

5

Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice.

Ortega-Gutiérrez S, Leung D, Ficarro S, Peters EC, Cravatt BF. Ortega-Gutiérrez S, et al. Among authors: leung d. PLoS One. 2008 Jul 2;3(7):e2486. doi: 10.1371/journal.pone.0002486. PLoS One. 2008. PMID: 18596935 Free PMC article.

6

Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase.

Romero FA, Du W, Hwang I, Rayl TJ, Kimball FS, Leung D, Hoover HS, Apodaca RL, Breitenbucher JG, Cravatt BF, Boger DL. Romero FA, et al. Among authors: leung d. J Med Chem. 2007 Mar 8;50(5):1058-68. doi: 10.1021/jm0611509. Epub 2007 Feb 6. J Med Chem. 2007. PMID: 17279740 Free PMC article.

7

Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase.

Hardouin C, Kelso MJ, Romero FA, Rayl TJ, Leung D, Hwang I, Cravatt BF, Boger DL. Hardouin C, et al. Among authors: leung d. J Med Chem. 2007 Jul 12;50(14):3359-68. doi: 10.1021/jm061414r. Epub 2007 Jun 9. J Med Chem. 2007. PMID: 17559203 Free PMC article.

8

Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity.

Lichtman AH, Leung D, Shelton CC, Saghatelian A, Hardouin C, Boger DL, Cravatt BF. Lichtman AH, et al. Among authors: leung d. J Pharmacol Exp Ther. 2004 Nov;311(2):441-8. doi: 10.1124/jpet.104.069401. Epub 2004 Jun 30. J Pharmacol Exp Ther. 2004. PMID: 15229230

9

Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics.

Boger DL, Miyauchi H, Du W, Hardouin C, Fecik RA, Cheng H, Hwang I, Hedrick MP, Leung D, Acevedo O, Guimarães CR, Jorgensen WL, Cravatt BF. Boger DL, et al. Among authors: leung d. J Med Chem. 2005 Mar 24;48(6):1849-56. doi: 10.1021/jm049614v. J Med Chem. 2005. PMID: 15771430 Free PMC article.

10

Understanding the Risk of Social Vulnerability for the Chinese Diaspora during the COVID-19 Pandemic: A Model Driving Risk Perception and Threat Appraisal of Risk Communication-A Qualitative Study.

Leung DYL, Hwu H, Khan S, Mamuji A, Rozdilsky J, Chu T, Lee C. Leung DYL, et al. Int J Environ Res Public Health. 2024 Apr 21;21(4):512. doi: 10.3390/ijerph21040512. Int J Environ Res Public Health. 2024. PMID: 38673423 Free PMC article.

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