Lewin NE - Search Results

1

Characterization of the interaction of phorbol esters with the C1 domain of MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase) alpha/beta.

Choi SH, Czifra G, Kedei N, Lewin NE, Lazar J, Pu Y, Marquez VE, Blumberg PM. Choi SH, et al. Among authors: lewin ne. J Biol Chem. 2008 Apr 18;283(16):10543-9. doi: 10.1074/jbc.M707463200. Epub 2008 Feb 7. J Biol Chem. 2008. PMID: 18263588 Free PMC article.

2

Conformationally constrained analogues of diacylglycerol. 19. Synthesis and protein kinase C binding affinity of diacylglycerol lactones bearing an N-hydroxylamide side chain.

Choi Y, Kang JH, Lewin NE, Blumberg PM, Lee J, Marquez VE. Choi Y, et al. Among authors: lewin ne. J Med Chem. 2003 Jun 19;46(13):2790-3. doi: 10.1021/jm030082c. J Med Chem. 2003. PMID: 12801241

3

[3H]Phorbol 12,13-dibutyrate binding assay for protein kinase C and related proteins.

Lewin NE, Blumberg PM. Lewin NE, et al. Methods Mol Biol. 2003;233:129-56. doi: 10.1385/1-59259-397-6:129. Methods Mol Biol. 2003. PMID: 12840504 No abstract available.

4

Conformationally constrained analogues of diacylglycerol. 20. The search for an elusive binding site on protein kinase C through relocation of the carbonyl pharmacophore along the sn-1 side chain of 1,2-diacylglycerol lactones.

Tamamura H, Sigano DM, Lewin NE, Blumberg PM, Marquez VE. Tamamura H, et al. Among authors: lewin ne. J Med Chem. 2004 Jan 29;47(3):644-55. doi: 10.1021/jm030454h. J Med Chem. 2004. PMID: 14736244

5

Conformationally constrained analogues of diacylglycerol (DAG). 23. Hydrophobic ligand-protein interactions versus ligand-lipid interactions of DAG-lactones with protein kinase C (PK-C).

Tamamura H, Sigano DM, Lewin NE, Peach ML, Nicklaus MC, Blumberg PM, Marquez VE. Tamamura H, et al. Among authors: lewin ne. J Med Chem. 2004 Sep 23;47(20):4858-64. doi: 10.1021/jm049723+. J Med Chem. 2004. PMID: 15369389

6

A novel diacylglycerol-lactone shows marked selectivity in vitro among C1 domains of protein kinase C (PKC) isoforms alpha and delta as well as selectivity for RasGRP compared with PKCalpha.

Pu Y, Perry NA, Yang D, Lewin NE, Kedei N, Braun DC, Choi SH, Blumberg PM, Garfield SH, Stone JC, Duan D, Marquez VE. Pu Y, et al. Among authors: lewin ne. J Biol Chem. 2005 Jul 22;280(29):27329-38. doi: 10.1074/jbc.M414132200. Epub 2005 May 27. J Biol Chem. 2005. PMID: 15923197 Free article.

7

Conformationally constrained analogues of diacylglycerol (DAG). 25. Exploration of the sn-1 and sn-2 carbonyl functionality reveals the essential role of the sn-1 carbonyl at the lipid interface in the binding of DAG-lactones to protein kinase C.

Kang JH, Peach ML, Pu Y, Lewin NE, Nicklaus MC, Blumberg PM, Marquez VE. Kang JH, et al. Among authors: lewin ne. J Med Chem. 2005 Sep 8;48(18):5738-48. doi: 10.1021/jm050352m. J Med Chem. 2005. PMID: 16134942 Free PMC article.

8

Conformationally constrained analogues of diacylglycerol. 26. Exploring the chemical space surrounding the C1 domain of protein kinase C with DAG-lactones containing aryl groups at the sn-1 and sn-2 positions.

Kang JH, Benzaria S, Sigano DM, Lewin NE, Pu Y, Peach ML, Blumberg PM, Marquez VE. Kang JH, et al. Among authors: lewin ne. J Med Chem. 2006 Jun 1;49(11):3185-203. doi: 10.1021/jm060011o. J Med Chem. 2006. PMID: 16722637

9

Conformationally constrained analogues of diacylglycerol (DAG). 27. Modulation of membrane translocation of protein kinase C (PKC) isozymes alpha and delta by diacylglycerol lactones (DAG-lactones) containing rigid-rod acyl groups.

Malolanarasimhan K, Kedei N, Sigano DM, Kelley JA, Lai CC, Lewin NE, Surawski RJ, Pavlyukovets VA, Garfield SH, Wincovitch S, Blumberg PM, Marquez VE. Malolanarasimhan K, et al. Among authors: lewin ne. J Med Chem. 2007 Mar 8;50(5):962-78. doi: 10.1021/jm061289j. Epub 2007 Feb 7. J Med Chem. 2007. PMID: 17284021

10

Conformationally constrained analogues of diacylglycerol (DAG). 28. DAG-dioxolanones reveal a new additional interaction site in the C1b domain of PKC delta.

Choi Y, Pu Y, Peach ML, Kang JH, Lewin NE, Sigano DM, Garfield SH, Blumberg PM, Marquez VE. Choi Y, et al. Among authors: lewin ne. J Med Chem. 2007 Jul 26;50(15):3465-81. doi: 10.1021/jm0702579. Epub 2007 Jun 26. J Med Chem. 2007. PMID: 17591763

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